iPTMnet Report for Q8IWS0 (PHF6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IWS0 / PHF6_HUMAN
Protein Name PHD finger protein 6
Gene Name Name: PHF6
Synonyms:CENP-31,KIAA1823;
Organism Homo sapiens (Human)

PRO ID PR:Q8IWS0
DAG View
PRO Name PHD finger protein 6 (human)
Definition A PHD finger protein 6 that is encoded in the genome of human.
Short Label hPHF6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IWS0 (PHF6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
S4 Phosphorylation PhosphoSitePlus
K8 Sumoylation PhosphoSitePlus
T12 Phosphorylation PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
C107 Methylation IEDB 31844290
K112 Ubiquitination PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
S120 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
Y124 Phosphorylation PhosphoSitePlus
Y127 Phosphorylation PhosphoSitePlus
T134 Phosphorylation PhosphoSitePlus
S138 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17287340, 18669648, 32399860, ...23186163, 19690332
S145 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 18669648, 23186163, ...20068231
F146 Phosphorylation UniProt 18669648
S154 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus 18669648, 17287340, 18847512
S155 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 18847512, ...18669648, 23186163
S158 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S162 Phosphorylation PhosphoSitePlus
K169 Methylation PhosphoSitePlus
K173 Acetylation PhosphoSitePlus
K173 Methylation PhosphoSitePlus
K173 Sumoylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus
S183 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S184 Phosphorylation PhosphoSitePlus
T187 Phosphorylation PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
Y195 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S199 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 17287340
S203 Phosphorylation PhosphoSitePlus
S204 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S206 Phosphorylation PhosphoSitePlus
T208 Phosphorylation PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
K227 Acetylation PhosphoSitePlus
K227 Sumoylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
K266 Sumoylation PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K310 Ubiquitination PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
R319 Methylation PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
R335 Methylation PhosphoSitePlus
S344 Phosphorylation PhosphoSitePlus
K345 Sumoylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
K349 Sumoylation PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
T358 O-Glycosylation GlyGen 32119511, 31492838, 28510447, ...34019948
T358 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
Site PTM Type PTM Enzyme Score Source PMID
S120 Phosphorylation HPRD 17525332, 20068231
Y124 Phosphorylation HPRD 20068231
Y127 Phosphorylation HPRD 20068231
T134 Phosphorylation HPRD 17081983
S138 Phosphorylation HPRD 18669648, 17287340, 17081983, ...20068231, 18452278
S145 Phosphorylation HPRD 17287340, 17081983, 18452278, ...19651622, 18669648, 20068231
S154 Phosphorylation HPRD 19413330, 18691976, 17287340, ...20230923, 18452278, 19651622, 18669648, 20068231
S155 Phosphorylation HPRD 19413330, 17287340, 20230923, ...19664995, 18452278, 19651622, 18669648, 20068231
S158 Phosphorylation HPRD 18669648
S183 Phosphorylation HPRD 18669648
Y195 Phosphorylation HPRD 18669648
S199 Phosphorylation HPRD 19651622, 18669648, 17287340, ...17081983, 20068231
S203 Phosphorylation HPRD 17081983, 20068231
S204 Phosphorylation HPRD 19651622, 17287340, 20068231
S206 Phosphorylation HPRD 19651622, 17081983, 20068231
T208 Phosphorylation HPRD 17081983, 20068231
S344 Phosphorylation HPRD 19562805
T358 Phosphorylation HPRD 17525332, 18077418
Site PTM Type PTM Enzyme Score Source PMID
S120 Phosphorylation HPRD 17525332, 20068231
Y124 Phosphorylation HPRD 20068231
Y127 Phosphorylation HPRD 20068231
S138 Phosphorylation HPRD   PhosphoSitePlus 17287340
S146 Phosphorylation HPRD   PhosphoSitePlus 18669648, 17287340, 18452278
S155 Phosphorylation HPRD   PhosphoSitePlus 18669648, 17287340, 18452278
S156 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340, 17081983, 18452278, ...18669648, 20068231
S159 Phosphorylation PhosphoSitePlus
S184 Phosphorylation HPRD 18669648
S185 Phosphorylation phospho.ELM 18669648
Y196 Phosphorylation HPRD 18669648
S200 Phosphorylation HPRD 19651622, 18669648, 17287340, ...17081983, 20068231
S204 Phosphorylation HPRD 17081983, 20068231
S205 Phosphorylation HPRD 19651622, 17287340, 20068231
S207 Phosphorylation HPRD 19651622, 17081983, 20068231
T209 Phosphorylation HPRD 17081983, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S83 F83 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S120 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S138 Y138 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S158 G158 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S159 G159 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S162 R162 Biomuta [ cosmic ]
K169 T169 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K173 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S183 Y183 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S184 Y184 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S199 C199 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S200 C200 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S203 C203 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S203 N203 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S204 N204 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S204 C204 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K211 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K211 E211 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S247 Y247 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R319 L319 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R319 Q319 Biomuta [ cosmic ] DOID:4362 / cervical cancer [ icgc ]
R319 * Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
R335 K335 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S346 G346 Biomuta DOID:263 / kidney cancer [ cosmic ]