iPTMnet Report for Q8IW41 (MAPKAPK5)
Protein Information
UniProt AC / UniProt ID | Q8IW41 / MAPK5_HUMAN |
Protein Name | MAP kinase-activated protein kinase 5 |
Gene Name | Name: MAPKAPK5 Synonyms:PRAK; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q8IW41 |
PRO Name | MAP kinase-activated protein kinase 5 (human) |
Definition | A MAP kinase-activated protein kinase 5 that is encoded in the genome of human. |
Short Label | hMAPKAPK5 |
Category | organism-gene |
Q8IW41 (MAPKAPK5) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S93 | Phosphorylation | score0 | RLIMS-P | 20647589 | ||
S115 | Phosphorylation | score4 | neXtProt PRO PhosphoSitePlus RLIMS-P | 17947239, 20734105 | ||
S115 | Phosphorylation | P17612 (PRKACA) | score4 | neXtProt PhosphoSitePlus | 17947239, 20734105 | |
K123 | Ubiquitination | score1 | PhosphoSitePlus | |||
S160 | Phosphorylation | score1 | PhosphoSitePlus | |||
K166 | Ubiquitination | score1 | PhosphoSitePlus | |||
T182 | Phosphorylation | score4 | neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt | 23186163, 15577943, 24651460, ... | ||
T182 | Phosphorylation | O15264 (MAPK13) | score2 | neXtProt | 9628874 | |
T182 | Phosphorylation | P28482 (MAPK1) | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor | 9628874, 21666810 | |
T182 | Phosphorylation | P31152 (MAPK4) | score2 | neXtProt | 19473979 | |
T182 | Phosphorylation | P45984 (MAPK9) | score3 | phospho.ELM PhosphoSitePlus | 9628874 | |
T182 | Phosphorylation | P53778 (MAPK12) | score2 | neXtProt | 9628874 | |
T182 | Phosphorylation | Q15759 (MAPK11) | score3 | neXtProt phospho.ELM PhosphoSitePlus Signor | 9628874 | |
T182 | Phosphorylation | Q16539 (MAPK14) | score3 | neXtProt phospho.ELM PhosphoSitePlus Signor | 9628874 | |
T182 | Phosphorylation | Q16659 (MAPK6) | score3 | neXtProt | 15577943, 19473979 | |
T186 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y188 | Phosphorylation | score1 | PhosphoSitePlus | |||
K205 | Ubiquitination | score1 | PhosphoSitePlus | |||
S206 | Phosphorylation | score1 | PhosphoSitePlus | |||
S212 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 12808055 | ||
T214 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y242 | Phosphorylation | score0 | RLIMS-P | 24651460 | ||
K286 | Ubiquitination | score1 | PhosphoSitePlus | |||
S348 | Phosphorylation | score1 | PhosphoSitePlus | |||
S354 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
T368 | Phosphorylation | score1 | PhosphoSitePlus | |||
S386 | Phosphorylation | score1 | PhosphoSitePlus | |||
S469 | Phosphorylation | score1 | PhosphoSitePlus | |||
S472 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T182 | Phosphorylation | score2 | HPRD | 18669648, 9628874 | ||
T182 | Phosphorylation | Q15759 (MAPK11) | score2 | HPRD | 18669648, 9628874 | |
T182 | Phosphorylation | Q16539 (MAPK14) | score2 | HPRD | 18669648, 9628874 | |
T214 | Phosphorylation | score0 | HPRD | 19413330 | ||
S472 | Phosphorylation | score0 | HPRD | 19413330 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T182 | Phosphorylation | score2 | HPRD | 18669648, 9628874 | ||
T182 | Phosphorylation | Q15759 (MAPK11) | score2 | HPRD | 18669648, 9628874 | |
T182 | Phosphorylation | Q16539 (MAPK14) | score2 | HPRD | 18669648, 9628874 | |
T214 | Phosphorylation | score0 | HPRD | 19413330 | ||
S470 | Phosphorylation | score0 | HPRD | 19413330 |
Q8IW41 (MAPKAPK5) as PTM Enzyme
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000048332 (hMAPKAPK5/Phos:1) | pS115 | PRO | |||
PR:000048333 (hMAPKAPK5/Phos:2) | pT182 | PRO |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S115 | I115 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
T182 | P182 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] | |
T186 | I186 | Biomuta | [ cosmic ] | |
S212 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
T214 | M214 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
K286 | N286 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S470 | Y470 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S472 | Y472 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] |