iPTMnet Report for Q8IVM0 (CCDC50)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IVM0 / CCD50_HUMAN
Protein Name Coiled-coil domain-containing protein 50
Gene Name Name: CCDC50
Synonyms:C3orf6;
Organism Homo sapiens (Human)

PRO ID PR:Q8IVM0
DAG View
PRO Name coiled-coil domain-containing protein 50 (human)
Definition A coiled-coil domain-containing protein 50 that is encoded in the genome of human.
Short Label hCCDC50
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IVM0 (CCDC50) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378
S5 Phosphorylation PhosphoSitePlus   UniProt 23186163
S32 Phosphorylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
Y140 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
Y144 Phosphorylation PhosphoSitePlus
Y145 Phosphorylation PhosphoSitePlus
Y146 Phosphorylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
T162 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
Y174 Phosphorylation PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
Y217 Phosphorylation P06239 (LCK) , P00533 (EGFR) neXtProt   PhosphoSitePlus   Signor 19059208
K218 Acetylation PhosphoSitePlus
K219 Acetylation PhosphoSitePlus
K221 Acetylation PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
K238 Sumoylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
T241 O-Glycosylation GlyGen 30379171
K243 Ubiquitination PhosphoSitePlus
S247 O-Glycosylation GlyGen 30379171
S249 O-Glycosylation GlyGen 30379171
K250 Ubiquitination PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
T272 Phosphorylation PhosphoSitePlus
Y279 Phosphorylation P06239 (LCK) , P00533 (EGFR) neXtProt   PhosphoSitePlus   Signor 19059208
T280 Phosphorylation PhosphoSitePlus
T283 Phosphorylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
Y304 Phosphorylation P06239 (LCK) , P00533 (EGFR) neXtProt   PhosphoSitePlus   Signor 19059208
Site PTM Type PTM Enzyme Score Source PMID
Y140 Phosphorylation HPRD 15951569
Y144 Phosphorylation HPRD 17016520, 19901323, 17389395, ...17081983
Y145 Phosphorylation HPRD 17016520, 15951569, 19901323
Y279 Phosphorylation HPRD 17016520, 17389395, 17081983
Site PTM Type PTM Enzyme Score Source PMID
Y140 Phosphorylation HPRD   PhosphoSitePlus 17016520
Y144 Phosphorylation HPRD   PhosphoSitePlus 17016520
Y145 Phosphorylation HPRD   PhosphoSitePlus 15951569
S154 Phosphorylation PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
Y292 Phosphorylation PhosphoSitePlus
T310 Phosphorylation PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus
Y455 Phosphorylation HPRD 17016520, 17389395, 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K119 N119 Biomuta DOID:363 / uterine cancer [ icgc ]
K129 R129 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y144 C144 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y144 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y144 H144 Biomuta DOID:4159 / skin cancer [ cosmic ]
K157 E157 Biomuta DOID:363 / uterine cancer [ cosmic ]
S164 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S203 F203 Biomuta DOID:4159 / skin cancer [ cosmic ]
S209 T209 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K218 R218 Biomuta DOID:1324 / lung cancer [ cosmic ]
K259 * Biomuta DOID:3571 / liver cancer [ cosmic ]
T283 A283 Biomuta DOID:1324 / lung cancer [ cosmic ]
K294 I294 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S314 L314 Biomuta DOID:10283 / prostate cancer [ cosmic ]