iPTMnet Report for Q8IV63 (VRK3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IV63 / VRK3_HUMAN
Protein Name Inactive serine/threonine-protein kinase VRK3
Gene Name Name: VRK3
Organism Homo sapiens (Human)

PRO ID PR:Q8IV63
DAG View
PRO Name inactive serine/threonine-protein kinase VRK3 (human)
Definition An inactive serine/threonine-protein kinase VRK3 that is encoded in the genome of human.
Short Label hVRK3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IV63 (VRK3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R50 Methylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus   UniProt 23186163
S55 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T58 Phosphorylation PhosphoSitePlus
S59 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S66 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
T70 Phosphorylation PhosphoSitePlus
S71 O-Glycosylation GlyGen 23301498, 30379171, 35132862
S71 Phosphorylation PhosphoSitePlus
S82 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18669648, 19690332, ...20068231
S83 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...19690332, 20068231
S85 Phosphorylation PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus   UniProt 19690332
S95 Phosphorylation PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus
T104 Phosphorylation PhosphoSitePlus
S107 O-Glycosylation GlyGen 23301498, 30379171, 35132862
S107 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus   RLIMS-P 27346674
T112 Phosphorylation PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 27346674, 21406692
T119 Phosphorylation PhosphoSitePlus
S122 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 27346674, 21406692
T126 Phosphorylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus   RLIMS-P 27346674
S136 Phosphorylation IEDB   PhosphoSitePlus   RLIMS-P 32897882, 27869121, 27346674
T139 Phosphorylation IEDB 32897882
T154 Phosphorylation PhosphoSitePlus
T156 Phosphorylation PhosphoSitePlus
T159 Phosphorylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
K275 Acetylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
K410 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S55 Phosphorylation HPRD 18669648
S59 Phosphorylation HPRD 18669648, 19664994, 19664995
S82 Phosphorylation HPRD 18669648, 20068231
S83 Phosphorylation HPRD 18669648, 20068231, 18452278
Site PTM Type PTM Enzyme Score Source PMID
S411 Phosphorylation PhosphoSitePlus


Q8IV63 (VRK3) as PTM Enzyme



Substrate Site Score Source PMID
O75531 (BANF1) S4 PhosphoSitePlus 25899223


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S95 F95 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S122 G122 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S129 N129 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T139 M139 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T159 I159 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]