iPTMnet Report for Q8IUE6 (H2AC21)
Protein Information
UniProt AC / UniProt ID | Q8IUE6 / H2A2B_HUMAN |
Protein Name | Histone H2A type 2-B |
Gene Name | Name: H2AC21 Synonyms:HIST2H2AB; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q8IUE6 |
PRO Name | histone H2A type 2-B (human) |
Definition | A histone H2A type 2-B that is encoded in the genome of human. |
Short Label | hH2AC21 |
Category | organism-gene |
Q8IUE6 (H2AC21) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Acetylation | score1 | PRO | ||||
S2 | Acetylation | score1 | UniProt | 15823041 | ||
S2 | Phosphorylation | score2 | PRO UniProt | 15010469 | ||
K6 | Acetylation | score1 | PRO | 17709392 | ||
K10 | Acetylation | score1 | PRO | 18552846, 12937907 | ||
K14 | Ubiquitination | score1 | UniProt | 22713238, 22980979 | ||
K16 | Ubiquitination | score1 | UniProt | 22713238, 22980979 | ||
S19 | Phosphorylation | score1 | PhosphoSitePlus | |||
Q105 | Methylation | score1 | UniProt | 24352239 | ||
K119 | Acetylation | score1 | PhosphoSitePlus | |||
K119 | Methylation | score1 | PhosphoSitePlus | |||
K119 | Ubiquitination | score1 | PhosphoSitePlus | |||
K120 | Ubiquitination | score2 | PRO UniProt | 18400894, 16359901, 15386022, ... | ||
T121 | Phosphorylation | score2 | PRO UniProt | 19965387, 24140421, 15078818 |
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000044987 (hHIST2H2AB/InitMet-/Ac:1) | acK6 | PRO | 17709392 | ||
PR:000044988 (hHIST2H2AB/InitMet-/Ubiq:1) | ubK120 | PRO | 15386022, 18400894 | ||
PR:000044989 (hHIST2H2AB/InitMet-/Phos:1) | pS2 | PRO | 15010469 | ||
PR:000044991 (hHIST2H2AB/InitMet-/Ac:2) | acK10 | PRO | 12937907, 18552846 | ||
PR:000044995 (hHIST2H2AB/InitMet-/Phos:2) | pT121 | PRO | 19965387 | ||
PR:000047832 (hHIST2H2AB/InitMet-/N6AcLys+) | ac | PRO |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S2 | P2 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
S2 | L2 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
S19 | T19 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
S19 | * | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
Q105 | H105 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
K119 | E119 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] |