iPTMnet Report for Q8IU81 (IRF2BP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IU81 / I2BP1_HUMAN
Protein Name Interferon regulatory factor 2-binding protein 1
Gene Name Name: IRF2BP1
Organism Homo sapiens (Human)

PRO ID PR:Q8IU81
DAG View
PRO Name interferon regulatory factor 2-binding protein 1 (human)
Definition An interferon regulatory factor 2-binding protein 1 that is encoded in the genome of human.
Short Label hIRF2BP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IU81 (IRF2BP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S58 Phosphorylation PhosphoSitePlus
S66 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569, ...20068231
K73 Ubiquitination PhosphoSitePlus
R120 Methylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus   UniProt 23186163, 18220336
Y130 Phosphorylation PhosphoSitePlus
R177 Methylation PhosphoSitePlus   UniProt 24129315
S186 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 20068231
R189 Methylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
R245 Methylation PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
Y268 Phosphorylation PhosphoSitePlus
C280 Methylation IEDB 33981976, 31844290
K306 Ubiquitination PhosphoSitePlus
K314 Sumoylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
Y354 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus   UniProt 23186163
T377 Phosphorylation PhosphoSitePlus
K382 Sumoylation PhosphoSitePlus
S384 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 18212344, 20068231
S413 Phosphorylation PhosphoSitePlus
T416 Phosphorylation PhosphoSitePlus
S421 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...24275569, 20068231
S436 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18452278, 19651622, 18669648, 24275569, 19690332, 20068231
K438 Ubiquitination PhosphoSitePlus
S453 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 19664995, 18452278, 19651622, 18669648, 24275569, 20068231
S457 O-Glycosylation GlyGen 32574038
S457 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648
S458 O-Glycosylation GlyGen 23301498, 30379171, 32574038, ...34725712, 30059200, 29351928, 35132862
T459 O-Glycosylation GlyGen 23301498, 30379171, 32574038, ...34725712, 30059200, 29351928, 35132862
T464 O-Glycosylation GlyGen 23301498, 30379171, 32574038, ...34725712, 30059200, 29351928, 35132862
S478 Phosphorylation PhosphoSitePlus
S491 Phosphorylation HPRD 20068231
T493 Phosphorylation HPRD 20068231
K536 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R177 Q177 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
R177 L177 Biomuta DOID:1612 / breast cancer [ icgc ]
S194 C194 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S371 F371 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K382 N382 Biomuta DOID:184 / bone cancer [ cosmic ]
S384 F384 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S384 T384 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S413 F413 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S457 F457 Biomuta DOID:4159 / skin cancer [ cosmic ]