iPTMnet Report for Q86YW9 (MED12L)
Protein Information
UniProt AC / UniProt ID | Q86YW9 / MD12L_HUMAN |
Protein Name | Mediator of RNA polymerase II transcription subunit 12-like protein |
Gene Name | Name: MED12L Synonyms:KIAA1635,TNRC11L,TRALP,TRALPUSH;ORFNames:PRO0314; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q86YW9 |
PRO Name | mediator of RNA polymerase II transcription subunit 12-like protein (human) |
Definition | A mediator of RNA polymerase II transcription subunit 12-like protein that is encoded in the genome of human. |
Short Label | hMED12L |
Category | organism-gene |
Q86YW9 (MED12L) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K82 | Ubiquitination | score1 | PhosphoSitePlus | |||
S137 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y167 | Phosphorylation | score1 | PhosphoSitePlus | |||
K432 | Ubiquitination | score1 | PhosphoSitePlus | |||
K446 | Ubiquitination | score1 | PhosphoSitePlus | |||
T462 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18669648 | ||
T474 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y484 | Phosphorylation | score1 | PhosphoSitePlus | |||
K530 | Ubiquitination | score1 | PhosphoSitePlus | |||
S628 | Phosphorylation | score1 | PhosphoSitePlus | |||
T630 | Phosphorylation | score1 | PhosphoSitePlus | |||
S632 | Phosphorylation | score1 | PhosphoSitePlus | |||
T633 | Phosphorylation | score1 | PhosphoSitePlus | |||
S637 | Phosphorylation | score1 | PhosphoSitePlus | |||
T671 | Phosphorylation | score1 | PhosphoSitePlus | |||
S678 | Phosphorylation | score1 | PhosphoSitePlus | |||
K735 | Ubiquitination | score1 | PhosphoSitePlus | |||
K746 | Ubiquitination | score1 | PhosphoSitePlus | |||
K749 | Ubiquitination | score1 | PhosphoSitePlus | |||
K771 | Ubiquitination | score1 | PhosphoSitePlus | |||
S922 | Phosphorylation | score1 | PhosphoSitePlus | |||
S923 | Phosphorylation | score1 | PhosphoSitePlus | |||
K956 | Ubiquitination | score1 | PhosphoSitePlus | |||
K958 | Ubiquitination | score1 | PhosphoSitePlus | |||
K998 | Ubiquitination | score1 | PhosphoSitePlus | |||
C1096 | Methylation | score1 | IEDB | 31844290 | ||
K1150 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1200 | Ubiquitination | score1 | PhosphoSitePlus | |||
T1220 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1222 | Phosphorylation | score1 | PhosphoSitePlus | |||
K1226 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1230 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1298 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1339 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1431 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1457 | Ubiquitination | score1 | PhosphoSitePlus | |||
T1487 | Phosphorylation | score1 | PhosphoSitePlus | |||
K1510 | Ubiquitination | score1 | PhosphoSitePlus | |||
S1615 | Phosphorylation | score1 | PhosphoSitePlus | |||
K1650 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1660 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1668 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1670 | Ubiquitination | score1 | PhosphoSitePlus | |||
S1755 | Phosphorylation | score1 | PhosphoSitePlus | |||
K1851 | Ubiquitination | score1 | PhosphoSitePlus | |||
T2116 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S137 | I137 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
T462 | M462 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] | |
S632 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S923 | F923 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K956 | N956 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
K1150 | N1150 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
K1200 | N1200 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
S1222 | L1222 | Biomuta | DOID:2021 / placenta cancer [ cosmic ] | |
K1226 | Q1226 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
K1660 | N1660 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
T2116 | M2116 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] |