iPTMnet Report Q86WV6 STING1

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q86WV6 / STING_HUMAN
Protein Name	Stimulator of interferon genes protein
Gene Name	Name: STING1 Synonyms:ERIS;
Organism	Homo sapiens (Human)

PRO ID	PR:Q86WV6 DAG View
PRO Name	stimulator of interferon genes protein (human)
Definition	A transmembrane protein 173 that is encoded in the genome of human.
Short Label	hSTING1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q86WV6 (STING1) as Substrate

Q86WV6

Condensed View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T84	Phosphorylation		score1	PhosphoSitePlus
	C148	Methylation		score1	IEDB	31844290
	K150	Ubiquitination		score4	PRO PhosphoSitePlus UniProt	19285439, 21074459
	K236	Ubiquitination		score2	UniProt	31968013
	Y240	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	32582856
	Y245	Phosphorylation		score1	PhosphoSitePlus
	K289	Ubiquitination		score1	PhosphoSitePlus
	K338	Acetylation		score1	PhosphoSitePlus
	K338	Ubiquitination		score1	PhosphoSitePlus
	S345	Phosphorylation		score1	PhosphoSitePlus
	K347	Ubiquitination		score1	PhosphoSitePlus
	S358	Phosphorylation		score4	neXtProt PhosphoSitePlus Signor UniProt	22394562, 25636800, 18818105
	S358	Phosphorylation	Q9UHD2 (TBK1)	score4	neXtProt PhosphoSitePlus Signor	22394562, 18818105
	S366	Phosphorylation		score4	PhosphoSitePlus RLIMS-P UniProt	32753499, 25636800, 32690950, ...32582856, 24119841, 27302953, 30321235, 29491158
	S366	Phosphorylation	O75385 (ULK1)	score2	PhosphoSitePlus	24119841
	K370	Ubiquitination		score1	PhosphoSitePlus

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000049479 (hTMEM173/Ubiq:1)	ubK150		PRO

PTM-dependent PPI

	PTM type	Substrate	Site	Interactant	Association type	Source	PMID
	Phosphorylation	Q86WV6 (STING1)	S366	Q14653 (IRF3)	inhibited_association	eFIP	25254379