iPTMnet Report for Q86WC4 (OSTM1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86WC4 / OSTM1_HUMAN
Protein Name Osteopetrosis-associated transmembrane protein 1 precursor
Gene Name Name: OSTM1
Synonyms:GL;ORFNames:HSPC019,UNQ6098/PRO21201;
Organism Homo sapiens (Human)

PRO ID PR:Q86WC4
DAG View
PRO Name osteopetrosis-associated transmembrane protein 1 (human)
Definition An osteopetrosis-associated transmembrane protein 1 that is encoded in the genome of human.
Short Label hOSTM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86WC4 (OSTM1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N93 N-Glycosylation GlyGen 29741879, 24190977
N128 N-Glycosylation GlyGen 29741879
N135 N-Glycosylation GlyGen 24190977
C199 Methylation IEDB 31844290
N216 N-Glycosylation GlyGen 29741879
S218 O-Glycosylation GlyGen 35289036
K222 Ubiquitination PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
N263 N-Glycosylation GlyGen 29741879, 24190977
K321 Methylation PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
S322 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 19651622, ...18669648, 19690332, 20068231
S323 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18669648, 17081983
T324 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983, 20068231, ...19664995
S325 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18578522, 23186163, ...18767875, 19664995, 19651622, 18669648, 24275569, 19690332, 20068231
S333 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17081983, 19651622, ...18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N216 K216 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S218 L218 Biomuta DOID:4159 / skin cancer [ cosmic ]
T324 I324 Biomuta DOID:1324 / lung cancer [ cosmic ]