iPTMnet Report for Q86W56 (PARG)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86W56 / PARG_HUMAN
Protein Name Poly(ADP-ribose) glycohydrolase
Gene Name Name: PARG
Organism Homo sapiens (Human)

PRO ID PR:Q86W56
DAG View
PRO Name poly(ADP-ribose) glycohydrolase (human)
Definition A poly(ADP-ribose) glycohydrolase that is encoded in the genome of human.
Short Label hPARG
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86W56 (PARG) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
T21 Phosphorylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus   UniProt 23186163
S54 Phosphorylation PhosphoSitePlus
R66 Methylation PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus   UniProt 23186163
K75 Methylation PhosphoSitePlus
K77 Methylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
Y119 Phosphorylation PhosphoSitePlus
S130 Phosphorylation PhosphoSitePlus
S133 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S137 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T139 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S190 Phosphorylation PhosphoSitePlus
S197 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19105632, 19690332
T199 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19105632, 19690332
S201 Phosphorylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus   UniProt 24275569
S264 Phosphorylation PhosphoSitePlus   UniProt 24275569
S268 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus   UniProt 23186163
S291 Phosphorylation PhosphoSitePlus   UniProt 23186163
S298 Phosphorylation PhosphoSitePlus   UniProt 19105632
S302 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S316 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 23186163
S323 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
Y442 Phosphorylation PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus   UniProt 23186163
C467 Methylation IEDB 31844290
K503 Acetylation PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
T541 Phosphorylation PhosphoSitePlus
K546 Ubiquitination PhosphoSitePlus
T548 Phosphorylation PhosphoSitePlus
K554 Ubiquitination PhosphoSitePlus
Y560 Phosphorylation IEDB 35494241
K616 Methylation PhosphoSitePlus
S632 Phosphorylation PhosphoSitePlus
K650 Ubiquitination PhosphoSitePlus
Y656 Phosphorylation PhosphoSitePlus
Y912 Phosphorylation PhosphoSitePlus
S913 Phosphorylation PhosphoSitePlus
T919 Phosphorylation PhosphoSitePlus
T945 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S133 Phosphorylation HPRD 18669648, 20068231
S137 Phosphorylation HPRD 18767875, 18669648, 20068231
T139 Phosphorylation HPRD 18669648
S197 Phosphorylation HPRD 18669648
T199 Phosphorylation HPRD 18669648
S286 Phosphorylation HPRD 19664994
S291 Phosphorylation HPRD 18767875
S302 Phosphorylation HPRD 19651622
S316 Phosphorylation HPRD 15302935
S632 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S54 P54 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T548 I548 Biomuta DOID:1324 / lung cancer [ cosmic ]
K650 R650 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S913 G913 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]