iPTMnet Report for Q86VZ1 (P2RY8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86VZ1 / P2RY8_HUMAN
Protein Name P2Y purinoceptor 8
Gene Name Name: P2RY8
Organism Homo sapiens (Human)

PRO ID PR:Q86VZ1
DAG View
PRO Name P2Y purinoceptor 8 (human)
Definition A P2Y purinoceptor 8 that is encoded in the genome of human.
Short Label hP2RY8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86VZ1 (P2RY8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N5 N-Glycosylation GlyGen   UniProt 19349973, 24190977
S6 Phosphorylation PhosphoSitePlus
N11 N-Glycosylation GlyGen   UniProt 19349973, 24190977
T13 Phosphorylation HPRD   PhosphoSitePlus 18491316
Y127 Phosphorylation PhosphoSitePlus
S130 Phosphorylation PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
Y139 Phosphorylation PhosphoSitePlus
C212 Methylation IEDB 31844290
S263 Phosphorylation PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
T320 Phosphorylation PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
T331 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T320 S320 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T320 M320 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S327 F327 Biomuta DOID:4159 / skin cancer [ cosmic ]
S327 C327 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S327 Y327 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T331 M331 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ]
S332 P332 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S335 F335 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]