iPTMnet Report for Q86U44 (METTL3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86U44 / MTA70_HUMAN
Protein Name N6-adenosine-methyltransferase catalytic subunit
Gene Name Name: METTL3
Synonyms:MTA70;
Organism Homo sapiens (Human)

PRO ID PR:Q86U44
DAG View
PRO Name N6-adenosine-methyltransferase catalytic subunit (human)
Definition An N6-adenosine-methyltransferase catalytic subunit that is encoded in the genome of human.
Short Label hMETTL3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86U44 (METTL3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330
S2 Phosphorylation PhosphoSitePlus   UniProt 29348140
K27 Ubiquitination PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
R36 Methylation PhosphoSitePlus
S43 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 23186163, 16964243, 33217317, ...18669648, 29348140, 20068231
S48 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 29348140
S50 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 18669648, 29348140, 33217317
T54 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T57 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S64 Phosphorylation phospho.ELM 18669648
T65 Phosphorylation phospho.ELM 18669648
S67 Phosphorylation PhosphoSitePlus
K132 Sumoylation PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
S219 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 29348140, 23186163
K235 Ubiquitination PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
S243 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 29348140
K256 Ubiquitination PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
C326 Methylation IEDB 31844290
S344 Phosphorylation PhosphoSitePlus
T348 Phosphorylation PhosphoSitePlus   UniProt 29348140, 23186163
S350 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 29348140
T356 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K459 Ubiquitination PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
S525 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) PhosphoSitePlus   Signor 33217317
K566 Ubiquitination PhosphoSitePlus
K576 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S43 Phosphorylation HPRD 16964243, 18767875, 19664994, ...19664995, 17322306, 18669648, 20068231
S48 Phosphorylation HPRD 18669648
S50 Phosphorylation HPRD 18669648
T54 Phosphorylation HPRD 18669648
T57 Phosphorylation HPRD 18669648
S64 Phosphorylation HPRD 18669648, 20068231
T65 Phosphorylation HPRD 18669648
T74 Phosphorylation HPRD 20068231
S219 Phosphorylation HPRD 18669648, 20068231
S243 Phosphorylation HPRD 18669648
S350 Phosphorylation HPRD 17525332
T356 Phosphorylation HPRD 17525332


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 L2 Biomuta DOID:1319 / brain cancer [ cosmic ]
R36 W36 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S64 G64 Biomuta DOID:363 / uterine cancer [ icgc ]
S196 C196 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S219 L219 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S315 F315 Biomuta DOID:4159 / skin cancer [ cosmic ]