iPTMnet Report for Q7Z6J0 (SH3RF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z6J0 / SH3R1_HUMAN
Protein Name E3 ubiquitin-protein ligase SH3RF1
Gene Name Name: SH3RF1
Synonyms:KIAA1494,POSH,POSH1;
Organism Homo sapiens (Human)

PRO ID PR:Q7Z6J0
DAG View
PRO Name E3 ubiquitin-protein ligase SH3RF1 (human)
Definition An E3 ubiquitin-protein ligase SH3RF1 that is encoded in the genome of human.
Short Label hSH3RF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z6J0 (SH3RF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C28 Methylation IEDB 31844290
S108 Phosphorylation PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
Y143 Phosphorylation PhosphoSitePlus
Y145 Phosphorylation PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
S304 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 30361695, 23186163, 20068231, ...17535800
S304 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 17535800
S304 Phosphorylation P31751 (AKT2) neXtProt   PhosphoSitePlus   Signor 17535800
T306 Phosphorylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
T309 Phosphorylation PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
Y450 Phosphorylation PhosphoSitePlus
Y454 Phosphorylation PhosphoSitePlus
Y456 Phosphorylation PhosphoSitePlus
T505 O-Glycosylation GlyGen 23301498, 33214551, 32938750, ...35138101, 35254053, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 36240223, 30620550, 28657654, 29237092
K515 Ubiquitination PhosphoSitePlus
S519 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 36240223, 30620550, 28657654, 29237092
T520 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 36240223, 30620550, 28657654, 29237092
S525 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 36240223, 30620550, 28657654, 29237092
T529 Phosphorylation PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus   UniProt 23186163
S534 Phosphorylation PhosphoSitePlus
T535 Phosphorylation PhosphoSitePlus
S551 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 36240223, 30620550, 28657654, 29237092
S551 Phosphorylation PhosphoSitePlus
S553 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 36240223, 30620550, 28657654, 29237092
S561 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 36240223, 30620550, 28657654, 29237092
T578 Phosphorylation PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
T684 Phosphorylation PhosphoSitePlus
S692 Phosphorylation PhosphoSitePlus
S695 Phosphorylation PhosphoSitePlus
S697 Phosphorylation PhosphoSitePlus
S698 Phosphorylation PhosphoSitePlus
T706 Phosphorylation PhosphoSitePlus
S724 Phosphorylation PhosphoSitePlus
S727 Phosphorylation PhosphoSitePlus
T728 Phosphorylation PhosphoSitePlus
S735 Phosphorylation PhosphoSitePlus
S739 Phosphorylation PhosphoSitePlus
T741 Phosphorylation PhosphoSitePlus
S772 Phosphorylation PhosphoSitePlus
S800 Phosphorylation PhosphoSitePlus
S801 Phosphorylation PhosphoSitePlus
S804 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T54 Phosphorylation HPRD 20068231
S304 Phosphorylation HPRD 19651622, 20068231
T309 Phosphorylation HPRD 20068231
S551 Phosphorylation HPRD 20068231
T567 Phosphorylation HPRD 20068231
S568 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S108 G108 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S109 L109 Biomuta DOID:1612 / breast cancer [ cosmic ]
S125 A125 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y145 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S307 F307 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ]
Y456 C456 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S534 F534 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S561 L561 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T578 M578 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S697 P697 Biomuta DOID:363 / uterine cancer [ icgc ]
S724 F724 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S735 F735 Biomuta DOID:4159 / skin cancer [ cosmic ]
S739 L739 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S772 Y772 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S772 F772 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S801 F801 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S804 F804 Biomuta DOID:4159 / skin cancer [ cosmic ]