iPTMnet Report for Q7Z6E9 (RBBP6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z6E9 / RBBP6_HUMAN
Protein Name E3 ubiquitin-protein ligase RBBP6
Gene Name Name: RBBP6
Synonyms:P2PR,PACT,RBQ1;ORFNames:My038;
Organism Homo sapiens (Human)

PRO ID PR:Q7Z6E9
DAG View
PRO Name E3 ubiquitin-protein ligase RBBP6 (human)
Definition An E3 ubiquitin-protein ligase RBBP6 that is encoded in the genome of human.
Short Label hRBBP6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z6E9 (RBBP6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K7 Acetylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
T86 Phosphorylation PhosphoSitePlus
Y87 Phosphorylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
K130 Acetylation PhosphoSitePlus
S138 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y142 Phosphorylation PhosphoSitePlus
R187 Methylation PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
K208 Methylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
T213 Phosphorylation PhosphoSitePlus
T215 Phosphorylation PhosphoSitePlus
K217 Acetylation PhosphoSitePlus
Y218 Phosphorylation PhosphoSitePlus
T222 Phosphorylation PhosphoSitePlus
Y228 Phosphorylation PhosphoSitePlus
K232 Acetylation PhosphoSitePlus
S244 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
S245 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
S246 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
S247 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
K323 Sumoylation PhosphoSitePlus
S360 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
S363 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S432 Phosphorylation PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
T471 Phosphorylation PhosphoSitePlus
T487 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 29351928, 34019948, 32119511, 35254053, 28657654
T488 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 29351928, 34019948, 32119511, 35254053, 28657654
R492 Methylation PhosphoSitePlus
S516 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 18220336, ...15302935, 18669648, 19690332, 20068231
R522 Methylation PhosphoSitePlus
R530 Methylation PhosphoSitePlus
R534 Methylation PhosphoSitePlus
T631 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 29351928, 34019948, 32119511, 35254053, 28657654
K657 Sumoylation PhosphoSitePlus
K657 Ubiquitination PhosphoSitePlus
S682 Phosphorylation PhosphoSitePlus
S684 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S688 Phosphorylation PhosphoSitePlus
Y690 Phosphorylation PhosphoSitePlus
S691 Phosphorylation PhosphoSitePlus
S693 Phosphorylation PhosphoSitePlus
S694 Phosphorylation PhosphoSitePlus
T701 Phosphorylation PhosphoSitePlus
S712 Phosphorylation PhosphoSitePlus
S714 Phosphorylation PhosphoSitePlus
S724 Phosphorylation PhosphoSitePlus
S726 Phosphorylation PhosphoSitePlus
S728 Phosphorylation PhosphoSitePlus
S730 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S748 Phosphorylation PhosphoSitePlus
S750 Phosphorylation PhosphoSitePlus
S756 Phosphorylation PhosphoSitePlus
S758 Phosphorylation PhosphoSitePlus
S760 Phosphorylation PhosphoSitePlus
S768 Phosphorylation PhosphoSitePlus   UniProt 23186163
S770 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
S772 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 17081983
S780 Phosphorylation PhosphoSitePlus   UniProt 21406692
K809 Sumoylation PhosphoSitePlus
K809 Ubiquitination PhosphoSitePlus
S815 Phosphorylation PhosphoSitePlus   UniProt 23186163
K824 Ubiquitination PhosphoSitePlus
Y841 Phosphorylation PhosphoSitePlus
K843 Ubiquitination PhosphoSitePlus
S854 Phosphorylation PhosphoSitePlus
S861 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 20068231
S873 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
T876 Phosphorylation PhosphoSitePlus
R877 Methylation PhosphoSitePlus
Y883 Phosphorylation PhosphoSitePlus
R892 Methylation PhosphoSitePlus
K901 Acetylation PhosphoSitePlus
K901 Ubiquitination PhosphoSitePlus
K941 Ubiquitination PhosphoSitePlus
S945 Phosphorylation PhosphoSitePlus
T956 Phosphorylation PhosphoSitePlus
S957 Phosphorylation PhosphoSitePlus   UniProt 23186163
S960 Phosphorylation PhosphoSitePlus
K970 Ubiquitination PhosphoSitePlus
S979 Phosphorylation PhosphoSitePlus
T984 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S1052 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S1055 Phosphorylation PhosphoSitePlus
T1066 Phosphorylation PhosphoSitePlus
T1087 Phosphorylation PhosphoSitePlus
K1106 Sumoylation PhosphoSitePlus
K1109 Ubiquitination PhosphoSitePlus
K1122 Ubiquitination PhosphoSitePlus
T1173 Phosphorylation PhosphoSitePlus
S1179 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 19690332, 20068231
T1194 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S1203 Phosphorylation PhosphoSitePlus
T1215 Phosphorylation PhosphoSitePlus
S1221 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1222 Phosphorylation PhosphoSitePlus
S1226 Phosphorylation PhosphoSitePlus
T1228 Phosphorylation PhosphoSitePlus
S1237 Phosphorylation PhosphoSitePlus
T1238 Phosphorylation PhosphoSitePlus
S1239 Phosphorylation PhosphoSitePlus
S1240 Phosphorylation PhosphoSitePlus
T1256 Phosphorylation PhosphoSitePlus
Y1268 Phosphorylation PhosphoSitePlus
T1269 Phosphorylation phospho.ELM 18669648
T1271 Phosphorylation phospho.ELM 18669648
S1273 Phosphorylation phospho.ELM 18669648
T1274 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1277 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 23186163, 19690332, ...24275569
S1282 Phosphorylation PhosphoSitePlus
Y1299 Phosphorylation PhosphoSitePlus
S1328 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 17081983, ...21406692, 18318008, 18669648, 19690332, 20068231
T1336 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S1341 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1344 Acetylation PhosphoSitePlus
K1344 Ubiquitination PhosphoSitePlus
S1347 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1353 Phosphorylation PhosphoSitePlus
S1381 Phosphorylation PhosphoSitePlus
K1400 Ubiquitination PhosphoSitePlus
T1403 Phosphorylation PhosphoSitePlus
Y1408 Phosphorylation PhosphoSitePlus
S1422 Phosphorylation PhosphoSitePlus
K1441 Methylation PhosphoSitePlus
S1442 Phosphorylation PhosphoSitePlus
S1444 Phosphorylation PhosphoSitePlus
S1462 O-Glycosylation GlyGen 30379171
S1463 O-Glycosylation GlyGen 30379171
S1463 Phosphorylation PhosphoSitePlus
T1468 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S1500 Phosphorylation PhosphoSitePlus
K1531 Methylation PhosphoSitePlus
Y1549 Phosphorylation PhosphoSitePlus
T1551 Phosphorylation PhosphoSitePlus
S1560 Phosphorylation PhosphoSitePlus
K1571 Acetylation PhosphoSitePlus
S1622 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1625 Phosphorylation PhosphoSitePlus
S1626 Phosphorylation PhosphoSitePlus
Y1641 Phosphorylation phospho.ELM 18669648
S1644 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1646 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S1648 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 19690332
S1651 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S1692 Phosphorylation PhosphoSitePlus
S1694 Phosphorylation PhosphoSitePlus
S1695 Phosphorylation PhosphoSitePlus
S1697 Phosphorylation PhosphoSitePlus
S1699 Phosphorylation PhosphoSitePlus
S1701 Phosphorylation PhosphoSitePlus
S1703 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 29351928, 34019948, 32119511, 35254053, 28657654
S1703 Phosphorylation PhosphoSitePlus
S1705 Phosphorylation PhosphoSitePlus
S1707 Phosphorylation PhosphoSitePlus
S1709 Phosphorylation PhosphoSitePlus
S1719 Phosphorylation PhosphoSitePlus
S1726 Phosphorylation PhosphoSitePlus
K1782 Acetylation PhosphoSitePlus
K1786 Acetylation PhosphoSitePlus
K1786 Ubiquitination PhosphoSitePlus
K1788 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T53 Phosphorylation HPRD 20068231
T86 Phosphorylation HPRD 20068231
S138 Phosphorylation HPRD 18669648
S244 Phosphorylation HPRD 17081983, 20068231, 18452278
S245 Phosphorylation HPRD 17081983, 20068231, 18452278
S246 Phosphorylation HPRD 17081983, 20068231
S247 Phosphorylation HPRD 17081983, 20068231, 18452278
S360 Phosphorylation HPRD 18767875, 18669648, 17081983, ...20068231, 17924679
S363 Phosphorylation HPRD 18767875
S516 Phosphorylation HPRD 19413330, 18669648, 15302935, ...20068231, 17924679
S730 Phosphorylation HPRD 15302935
S748 Phosphorylation HPRD 20068231
S750 Phosphorylation HPRD 20068231
Y766 Phosphorylation HPRD 17081983
S768 Phosphorylation HPRD 19651622, 17081983, 20068231
S770 Phosphorylation HPRD 19651622, 17081983, 20068231
S772 Phosphorylation HPRD 19651622, 15302935, 20068231, ...18452278
Y845 Phosphorylation HPRD 17081983
S854 Phosphorylation HPRD 17081983
S861 Phosphorylation HPRD 17081983, 20068231
S873 Phosphorylation HPRD 18669648, 17081983, 20068231
T876 Phosphorylation HPRD 20068231
S960 Phosphorylation HPRD 19651622
S979 Phosphorylation HPRD 20068231
T984 Phosphorylation HPRD 20068231, 18452278
S1052 Phosphorylation HPRD 20068231
T1087 Phosphorylation HPRD 20068231
T1173 Phosphorylation HPRD 18767875
S1179 Phosphorylation HPRD 17322306, 18212344, 19664995, ...18452278, 19651622, 18669648, 20068231
T1194 Phosphorylation HPRD 20068231, 18452278
S1203 Phosphorylation HPRD 18452278
S1221 Phosphorylation HPRD 20068231
T1222 Phosphorylation HPRD 19413330
T1258 Phosphorylation HPRD 17081983
T1269 Phosphorylation HPRD 18669648, 20068231
T1271 Phosphorylation HPRD 18669648
S1272 Phosphorylation HPRD 20068231
S1273 Phosphorylation HPRD 18669648, 20068231
T1274 Phosphorylation HPRD 18669648
S1277 Phosphorylation HPRD 15302935, 18452278
S1328 Phosphorylation HPRD 17322306, 18767875, 18452278, ...19651622, 18669648, 20068231
T1336 Phosphorylation HPRD 17525332
S1422 Phosphorylation HPRD 20068231
T1468 Phosphorylation HPRD 18669648, 17081983, 20068231
S1621 Phosphorylation HPRD 20068231
S1622 Phosphorylation HPRD 18669648
S1625 Phosphorylation HPRD 19007248, 20068231
S1626 Phosphorylation HPRD 20068231
Y1641 Phosphorylation HPRD 18669648, 17081983
S1644 Phosphorylation HPRD 18669648, 17081983
S1646 Phosphorylation HPRD 18669648, 18452278
S1648 Phosphorylation HPRD 18669648, 17081983, 18452278
S1651 Phosphorylation HPRD 19651622, 18669648, 17081983, ...18452278
S1699 Phosphorylation HPRD 19664995
S1705 Phosphorylation HPRD 19651622
S1709 Phosphorylation HPRD 19651622
Site PTM Type PTM Enzyme Score Source PMID
T53 Phosphorylation HPRD 20068231
T86 Phosphorylation HPRD 20068231
S138 Phosphorylation HPRD 18669648
S244 Phosphorylation HPRD 17081983, 20068231, 18452278
S245 Phosphorylation HPRD 17081983, 20068231, 18452278
S246 Phosphorylation HPRD 17081983, 20068231
S247 Phosphorylation HPRD 17081983, 20068231, 18452278
S360 Phosphorylation HPRD 18767875, 18669648, 17081983, ...20068231, 17924679
S363 Phosphorylation HPRD 18767875
S516 Phosphorylation HPRD 19413330, 18669648, 15302935, ...20068231, 17924679
S654 Phosphorylation PhosphoSitePlus
S657 Phosphorylation PhosphoSitePlus
S696 Phosphorylation HPRD 15302935
S714 Phosphorylation HPRD 20068231
S716 Phosphorylation HPRD 20068231
Y732 Phosphorylation HPRD 17081983
S734 Phosphorylation HPRD 19651622, 17081983, 20068231
S736 Phosphorylation HPRD 19651622, 17081983, 20068231
S738 Phosphorylation HPRD 19651622, 15302935, 20068231, ...18452278
Y811 Phosphorylation HPRD 17081983
S820 Phosphorylation HPRD 17081983
S827 Phosphorylation HPRD 17081983, 20068231
S839 Phosphorylation HPRD 18669648, 17081983, 20068231
T842 Phosphorylation HPRD 20068231
S926 Phosphorylation HPRD 19651622
S945 Phosphorylation HPRD 20068231
T950 Phosphorylation HPRD 20068231, 18452278
S1018 Phosphorylation HPRD 20068231
T1053 Phosphorylation HPRD 20068231
T1139 Phosphorylation HPRD 18767875
S1145 Phosphorylation HPRD 17322306, 18212344, 19664995, ...18452278, 19651622, 18669648, 20068231
T1160 Phosphorylation HPRD 20068231, 18452278
S1169 Phosphorylation HPRD 18452278
S1187 Phosphorylation HPRD 20068231
T1188 Phosphorylation HPRD 19413330
T1224 Phosphorylation HPRD 17081983
T1235 Phosphorylation HPRD 18669648, 20068231
T1237 Phosphorylation HPRD 18669648
S1238 Phosphorylation HPRD 20068231
S1239 Phosphorylation HPRD 18669648, 20068231
T1240 Phosphorylation HPRD 18669648
S1243 Phosphorylation HPRD 15302935, 18452278
S1294 Phosphorylation HPRD 17322306, 18767875, 18452278, ...19651622, 18669648, 20068231
T1302 Phosphorylation HPRD 17525332
S1388 Phosphorylation HPRD 20068231
T1434 Phosphorylation HPRD 18669648, 17081983, 20068231
S1587 Phosphorylation HPRD 20068231
S1588 Phosphorylation HPRD 18669648
S1591 Phosphorylation HPRD 19007248, 20068231
S1592 Phosphorylation HPRD 20068231
Y1607 Phosphorylation HPRD 18669648, 17081983
S1610 Phosphorylation HPRD 18669648, 17081983
S1612 Phosphorylation HPRD 18669648, 18452278
S1614 Phosphorylation HPRD 18669648, 17081983, 18452278
S1617 Phosphorylation HPRD 19651622, 18669648, 17081983, ...18452278
S1665 Phosphorylation HPRD 19664995
S1671 Phosphorylation HPRD 19651622
S1675 Phosphorylation HPRD 19651622
Site PTM Type PTM Enzyme Score Source PMID
T53 Phosphorylation HPRD 20068231
T86 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T53 A53 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T86 S86 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S138 C138 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y142 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
Y142 N142 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T215 I215 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S245 Y245 Biomuta DOID:4362 / cervical cancer [ icgc ]
S247 L247 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S360 F360 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S363 P363 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S654 F654 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S688 F688 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S694 L694 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ]
S714 F714 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S758 L758 Biomuta DOID:1319 / brain cancer [ icgc ]
S827 F827 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, cosmic ]
Y841 F841 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K843 E843 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S861 F861 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y883 D883 Biomuta DOID:1324 / lung cancer [ cosmic ]
R892 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S1187 N1187 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T1188 A1188 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1221 N1221 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T1222 A1222 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1243 G1243 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T1256 A1256 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
Y1268 F1268 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1277 G1277 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T1302 A1302 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T1336 A1336 Biomuta DOID:363 / uterine cancer [ icgc ]
S1353 I1353 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1444 P1444 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K1571 T1571 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1612 G1612 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1614 R1614 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1617 T1617 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S1646 G1646 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1648 R1648 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1651 T1651 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S1675 I1675 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:4362 / cervical cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic ]
S1694 G1694 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1694 I1694 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1694 N1694 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1707 T1707 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1709 I1709 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1782 Q1782 Biomuta DOID:363 / uterine cancer [ icgc ]