iPTMnet Report for Q7Z6B7 (SRGAP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z6B7 / SRGP1_HUMAN
Protein Name SLIT-ROBO Rho GTPase-activating protein 1
Gene Name Name: SRGAP1
Synonyms:ARHGAP13,KIAA1304;
Organism Homo sapiens (Human)

PRO ID PR:Q7Z6B7
DAG View
PRO Name SLIT-ROBO Rho GTPase-activating protein 1 (human)
Definition A SLIT-ROBO Rho GTPase-activating protein 1 that is encoded in the genome of human.
Short Label hSRGAP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z6B7 (SRGAP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y17 Phosphorylation PhosphoSitePlus
K22 Ubiquitination PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
K220 Acetylation PhosphoSitePlus
K222 Acetylation PhosphoSitePlus
K224 Acetylation PhosphoSitePlus
K235 Acetylation PhosphoSitePlus
Y359 Phosphorylation PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y446 Phosphorylation PhosphoSitePlus
T454 Phosphorylation PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
Y475 Phosphorylation PhosphoSitePlus
S493 Phosphorylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
Y499 Phosphorylation PhosphoSitePlus
T501 Phosphorylation PhosphoSitePlus
T510 Phosphorylation PhosphoSitePlus
T622 O-Glycosylation GlyGen 32574038, 30059200, 29351928, ...35132862, 31492838, 35254053
Y705 Phosphorylation PhosphoSitePlus
Y714 Phosphorylation PhosphoSitePlus
Y719 Phosphorylation PhosphoSitePlus
T738 Phosphorylation PhosphoSitePlus
S739 Phosphorylation PhosphoSitePlus
S769 Phosphorylation PhosphoSitePlus
Y773 Phosphorylation PhosphoSitePlus
S816 Phosphorylation PhosphoSitePlus
S819 Phosphorylation PhosphoSitePlus
S820 Phosphorylation PhosphoSitePlus
S835 Phosphorylation PhosphoSitePlus   UniProt 23186163
T837 Phosphorylation PhosphoSitePlus
R900 Methylation PhosphoSitePlus
S906 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S917 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
N920 N-Glycosylation GlyGen 29671580
S926 Phosphorylation PhosphoSitePlus
S932 Phosphorylation PhosphoSitePlus   UniProt 23186163
S940 Phosphorylation PhosphoSitePlus
S941 Phosphorylation PhosphoSitePlus
K983 Ubiquitination PhosphoSitePlus
T992 Phosphorylation PhosphoSitePlus
S999 O-Glycosylation GlyGen 34846842, 32574038, 30059200, ...35254053, 35132862, 31492838, 29351928
S999 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T1001 O-Glycosylation GlyGen 32574038, 30059200, 29351928, ...35132862, 31492838, 35254053
T1001 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T1004 O-Glycosylation GlyGen 32574038, 30059200, 29351928, ...35132862, 31492838, 35254053
T1004 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1005 O-Glycosylation GlyGen 32574038, 30059200, 29351928, ...35132862, 31492838, 35254053
S1005 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
T1006 O-Glycosylation GlyGen 32574038, 30620550
T1006 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1008 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1010 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
S1027 Phosphorylation PhosphoSitePlus
T1028 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1029 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1030 Phosphorylation phospho.ELM 18669648
S1031 Phosphorylation phospho.ELM 18669648
S1032 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Site PTM Type PTM Enzyme Score Source PMID
Y17 Phosphorylation HPRD 19664994
S407 Phosphorylation HPRD 17081983
T408 Phosphorylation HPRD 17081983
S410 Phosphorylation HPRD 17081983
S413 Phosphorylation HPRD 19651622
T414 Phosphorylation HPRD 17081983
S416 Phosphorylation HPRD 19651622
S816 Phosphorylation HPRD 19651622
S819 Phosphorylation HPRD 19651622
S820 Phosphorylation HPRD 19651622
S835 Phosphorylation HPRD 19651622, 20068231
T837 Phosphorylation HPRD 17081983, 20068231
S906 Phosphorylation HPRD 17081983, 20068231
S917 Phosphorylation HPRD 17081983
N920 N-Glycosylation PRO 29671580
S999 Phosphorylation HPRD 18669648, 20068231
T1001 Phosphorylation HPRD 18669648, 20068231
T1004 Phosphorylation HPRD 18669648, 20068231
S1005 Phosphorylation HPRD 18669648, 20068231
T1006 Phosphorylation HPRD 18669648
S1008 Phosphorylation HPRD 18669648, 20068231
S1010 Phosphorylation HPRD 18669648, 20068231
T1028 Phosphorylation HPRD 18669648
S1029 Phosphorylation HPRD 18669648
S1030 Phosphorylation HPRD 18669648
S1031 Phosphorylation HPRD 18669648
S1032 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y17 C17 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K455 E455 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S493 F493 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T501 I501 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T510 R510 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S820 I820 Biomuta DOID:1324 / lung cancer [ cosmic ]
S926 F926 Biomuta DOID:4159 / skin cancer [ cosmic ]
S999 Y999 Biomuta DOID:363 / uterine cancer [ icgc ]
T1001 P1001 Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T1006 M1006 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1008 F1008 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T1028 M1028 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S1029 G1029 Biomuta DOID:1612 / breast cancer [ icgc ]
S1030 F1030 Biomuta DOID:4159 / skin cancer [ cosmic ]