iPTMnet Report for Q7Z4I7 (LIMS2)
Protein Information
UniProt AC / UniProt ID | Q7Z4I7 / LIMS2_HUMAN |
Protein Name | LIM and senescent cell antigen-like-containing domain protein 2 |
Gene Name | Name: LIMS2 Synonyms:PINCH2; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q7Z4I7 |
PRO Name | LIM and senescent cell antigen-like-containing domain protein 2 (human) |
Definition | A LIM and senescent cell antigen-like-containing domain protein 2 that is encoded in the genome of human. |
Short Label | hLIMS2 |
Category | organism-gene |
Q7Z4I7 (LIMS2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
F22 | Phosphorylation | score1 | UniProt | 24275569 | ||
Y185 | Phosphorylation | score1 | PhosphoSitePlus | |||
K229 | Sumoylation | score1 | PhosphoSitePlus | |||
S270 | Phosphorylation | score1 | PhosphoSitePlus | |||
K274 | Ubiquitination | score1 | PhosphoSitePlus | |||
S282 | Phosphorylation | score1 | PhosphoSitePlus | |||
K289 | Ubiquitination | score1 | PhosphoSitePlus | |||
K295 | Ubiquitination | score1 | PhosphoSitePlus | |||
S324 | O-Glycosylation | score1 | GlyGen | 30379171, 28510447 | ||
S324 | Phosphorylation | score1 | PhosphoSitePlus | |||
T327 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
S328 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y14 | Phosphorylation | score1 | PhosphoSitePlus | |||
S22 | Phosphorylation | score1 | PhosphoSitePlus | |||
S348 | Phosphorylation | score0 | HPRD | 20068231 | ||
T351 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
S352 | Phosphorylation | score0 | HPRD | 18669648 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
Y185 | D185 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
S324 | L324 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S328 | F328 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
S348 | L348 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S352 | F352 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] |