iPTMnet Report for Q7L5N1 (COPS6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7L5N1 / CSN6_HUMAN
Protein Name COP9 signalosome complex subunit 6
Gene Name Name: COPS6
Synonyms:CSN6,HVIP;
Organism Homo sapiens (Human)

PRO ID PR:Q7L5N1
DAG View
PRO Name COP9 signalosome complex subunit 6 (human)
Definition A COP9 signalosome complex subunit 6 that is encoded in the genome of human.
Short Label hCOPS6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7L5N1 (COPS6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S60 Phosphorylation P31749 (AKT1) PhosphoSitePlus   RLIMS-P   Signor 33101846, 23095642, 26318036
K75 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
Y105 Phosphorylation PhosphoSitePlus
Y106 Phosphorylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
C143 S-Nitrosylation dbSNO 19483679
S148 Phosphorylation P28482 (MAPK1) PhosphoSitePlus   RLIMS-P 26267535
K153 Ubiquitination PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
Y241 Phosphorylation HPRD   PhosphoSitePlus 20068231
K243 Ubiquitination PhosphoSitePlus
Y261 Phosphorylation PhosphoSitePlus
S271 Methylation IEDB 32357974
K274 Ubiquitination PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
Y280 Phosphorylation PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
T298 Phosphorylation PhosphoSitePlus
C299 S-Nitrosylation dbSNO 26338901
T301 Phosphorylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
Y313 Phosphorylation PhosphoSitePlus
R315 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S60 P60 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S60 F60 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K97 N97 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y105 H105 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y241 F241 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R315 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R315 Q315 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]