iPTMnet Report for Q7KZF4 (SND1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7KZF4 / SND1_HUMAN
Protein Name Staphylococcal nuclease domain-containing protein 1
Gene Name Name: SND1
Synonyms:TDRD11;
Organism Homo sapiens (Human)

PRO ID PR:Q7KZF4
DAG View
PRO Name staphylococcal nuclease domain-containing protein 1 (human)
Definition A staphylococcal nuclease domain-containing protein 1 that is encoded in the genome of human.
Short Label hSND1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7KZF4 (SND1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895, ...25944712
S3 Phosphorylation HPRD   PhosphoSitePlus 18491316
S4 Phosphorylation PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus
S10 Phosphorylation HPRD   PhosphoSitePlus 19413330
S29 Phosphorylation PhosphoSitePlus
R40 Methylation PhosphoSitePlus
K71 Sumoylation PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
C96 Methylation IEDB 31844290
T98 Phosphorylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
T103 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 35271349, 28011284, 23186163, ...20068231
R107 Methylation PhosphoSitePlus
Y109 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15592455, 18083107
Y113 Phosphorylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
T172 Phosphorylation PhosphoSitePlus
K177 Acetylation PhosphoSitePlus
K177 Methylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
Y178 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
K193 Acetylation PhosphoSitePlus   UniProt 19608861
K193 Ubiquitination PhosphoSitePlus
S238 Phosphorylation HPRD   PhosphoSitePlus 17081983
T240 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
K249 Acetylation PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
Y329 Phosphorylation PhosphoSitePlus
T333 Phosphorylation PhosphoSitePlus
K339 Acetylation PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
K366 Acetylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
S372 Phosphorylation PhosphoSitePlus
T383 Phosphorylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
Y398 Phosphorylation PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
T418 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y421 Phosphorylation PhosphoSitePlus
S426 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 32645525, 19664994, ...19651622, 18669648, 24275569, 20166139, 20068231
T429 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983
T431 Phosphorylation PhosphoSitePlus
S436 Phosphorylation PhosphoSitePlus
C440 Methylation IEDB 31844290
C440 S-Nitrosylation dbSNO 19483679
S474 Phosphorylation PhosphoSitePlus
Y476 Phosphorylation PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus
K513 Sumoylation PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
R523 Methylation PhosphoSitePlus
S527 Phosphorylation PhosphoSitePlus
Y533 Phosphorylation PhosphoSitePlus
S536 Phosphorylation PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus
K541 Acetylation PhosphoSitePlus
C549 Methylation IEDB 31844290
S578 Phosphorylation PhosphoSitePlus
K586 Ubiquitination PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
S638 Phosphorylation PhosphoSitePlus
K641 Acetylation PhosphoSitePlus   UniProt 19608861
K641 Sumoylation PhosphoSitePlus
K641 Ubiquitination PhosphoSitePlus
S642 Phosphorylation PhosphoSitePlus
S645 Phosphorylation PhosphoSitePlus   UniProt 23186163
K651 Ubiquitination PhosphoSitePlus
K656 Ubiquitination PhosphoSitePlus
Y661 Phosphorylation PhosphoSitePlus
K676 Ubiquitination PhosphoSitePlus
K683 Ubiquitination PhosphoSitePlus
S727 Phosphorylation PhosphoSitePlus
Y728 Phosphorylation PhosphoSitePlus
K739 Ubiquitination PhosphoSitePlus
K752 Acetylation PhosphoSitePlus
K752 Ubiquitination PhosphoSitePlus
S755 Phosphorylation PhosphoSitePlus
K758 Ubiquitination PhosphoSitePlus
T779 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S781 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 24275569, 23186163, 17081983, ...20068231
S785 Phosphorylation PhosphoSitePlus   UniProt 23186163
R787 Methylation PhosphoSitePlus
T824 Phosphorylation PhosphoSitePlus
S834 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...28510447, 35138101, 30397120, 34725712, 26853435, 35008409, 34019948, 32870666, 32119511, 29351928
S834 Phosphorylation PhosphoSitePlus
K848 Sumoylation PhosphoSitePlus
K848 Ubiquitination PhosphoSitePlus
K857 Ubiquitination PhosphoSitePlus
K869 Ubiquitination PhosphoSitePlus
K873 Ubiquitination PhosphoSitePlus
T876 Phosphorylation PhosphoSitePlus
Y878 Phosphorylation PhosphoSitePlus
S884 Phosphorylation PhosphoSitePlus
K886 Ubiquitination PhosphoSitePlus
Y895 Phosphorylation PhosphoSitePlus
R899 Methylation PhosphoSitePlus
Y908 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15592455
S909 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332, 24275569
R910 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S3 P3 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R40 C40 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R40 L40 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R40 H40 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K71 N71 Biomuta DOID:1319 / brain cancer [ icgc ]
K88 N88 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T98 M98 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T98 A98 Biomuta DOID:1324 / lung cancer [ cosmic ]
R107 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
K116 R116 Biomuta [ cosmic ]
K249 N249 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S371 C371 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S372 N372 Biomuta DOID:363 / uterine cancer [ icgc ]
T383 A383 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T418 M418 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
C440 F440 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y476 C476 Biomuta DOID:3571 / liver cancer [ cosmic ]
S578 R578 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y661 C661 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S727 F727 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y728 F728 Biomuta DOID:1324 / lung cancer [ cosmic ]
K752 E752 Biomuta DOID:4159 / skin cancer [ cosmic ]
S755 Y755 Biomuta DOID:363 / uterine cancer [ icgc ]
S781 T781 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R787 L787 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R787 W787 Biomuta DOID:363 / uterine cancer [ icgc ]
T824 I824 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y878 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K886 R886 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R899 Q899 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R899 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]