iPTMnet Report for Q7KZ85 (SUPT6H)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7KZ85 / SPT6H_HUMAN
Protein Name Transcription elongation factor SPT6
Gene Name Name: SUPT6H
Synonyms:KIAA0162,SPT6H;
Organism Homo sapiens (Human)

PRO ID PR:Q7KZ85
DAG View
PRO Name transcription elongation factor SPT6 (human)
Definition A transcription elongation factor SPT6 that is encoded in the genome of human.
Short Label hSUPT6H
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7KZ85 (SUPT6H) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 21406692
S2 Phosphorylation RLIMS-P 24163256, 25182531
S7 Phosphorylation PhosphoSitePlus   UniProt 21406692
S12 Phosphorylation PhosphoSitePlus   UniProt 21406692
K29 Ubiquitination PhosphoSitePlus
S73 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S75 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S78 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T90 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S91 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
R95 Methylation PhosphoSitePlus
S125 O-Glycosylation GlyGen 33214551, 28510447, 35138101, ...35254053, 30379171, 32574038, 34725712, 26853435, 34019948, 25367160, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
S125 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...24275569, 17287340, 20068231
S179 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S267 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S279 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
T283 Phosphorylation PhosphoSitePlus
T292 Phosphorylation PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
K402 Acetylation PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
S456 Phosphorylation PhosphoSitePlus
Y464 Phosphorylation PhosphoSitePlus
Y470 Phosphorylation PhosphoSitePlus
R511 Methylation PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
K538 Ubiquitination PhosphoSitePlus
K615 Ubiquitination PhosphoSitePlus
T619 Phosphorylation PhosphoSitePlus
T621 Phosphorylation PhosphoSitePlus
C657 Methylation IEDB 31844290
Y685 Phosphorylation PhosphoSitePlus
Y722 Phosphorylation PhosphoSitePlus
K732 Ubiquitination PhosphoSitePlus
K738 Ubiquitination PhosphoSitePlus
Y740 Phosphorylation PhosphoSitePlus
K743 Acetylation PhosphoSitePlus   UniProt 19608861
S746 Phosphorylation PhosphoSitePlus
K777 Ubiquitination PhosphoSitePlus
C796 Methylation IEDB 31844290
K816 Ubiquitination PhosphoSitePlus
K844 Ubiquitination PhosphoSitePlus
C939 Methylation IEDB 31844290
K1002 Ubiquitination PhosphoSitePlus
K1005 Ubiquitination PhosphoSitePlus
T1062 Phosphorylation PhosphoSitePlus
Y1063 Phosphorylation PhosphoSitePlus
Y1076 Phosphorylation PhosphoSitePlus
S1079 Phosphorylation PhosphoSitePlus
K1100 Ubiquitination PhosphoSitePlus
T1122 Phosphorylation PhosphoSitePlus
Y1124 Phosphorylation PhosphoSitePlus
Y1134 Phosphorylation PhosphoSitePlus
T1139 Phosphorylation PhosphoSitePlus
T1172 Phosphorylation PhosphoSitePlus
K1243 Ubiquitination PhosphoSitePlus
K1248 Ubiquitination PhosphoSitePlus
K1274 Ubiquitination PhosphoSitePlus
C1281 Methylation IEDB 31844290
R1289 Methylation PhosphoSitePlus
K1294 Ubiquitination PhosphoSitePlus
K1297 Ubiquitination PhosphoSitePlus
K1341 Ubiquitination PhosphoSitePlus
Y1378 Phosphorylation PhosphoSitePlus
T1450 Phosphorylation PhosphoSitePlus
K1471 Ubiquitination PhosphoSitePlus
Y1486 Phosphorylation PhosphoSitePlus
K1512 Ubiquitination PhosphoSitePlus
Y1515 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1523 O-Glycosylation GlyGen 33214551, 28510447, 35138101, ...35254053, 28657654, 30379171, 32574038, 34725712, 26853435, 34019948, 25367160, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
T1523 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18847512, ...20068231
S1525 O-Glycosylation GlyGen 33214551, 28510447, 35138101, ...35254053, 28657654, 30379171, 32574038, 34725712, 26853435, 34019948, 25367160, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
S1525 Phosphorylation phospho.ELM 18669648
S1526 O-Glycosylation GlyGen 33214551, 28510447, 35138101, ...35254053, 28657654, 30379171, 32574038, 34725712, 26853435, 34019948, 25367160, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 31373491, 29237092
S1526 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1527 O-Glycosylation GlyGen 33214551, 28510447, 35138101, ...35254053, 30379171, 32574038, 34725712, 26853435, 34019948, 25367160, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
S1527 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S1528 O-Glycosylation GlyGen 33214551, 28510447, 35138101, ...35254053, 30379171, 32574038, 34725712, 26853435, 34019948, 25367160, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
S1528 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1530 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1532 O-Glycosylation GlyGen 33214551, 28510447, 35138101, ...35254053, 30379171, 32574038, 34725712, 26853435, 34019948, 25367160, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
T1532 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231, ...18220336
S1535 O-Glycosylation GlyGen 33214551, 28510447, 35138101, ...35254053, 30379171, 32574038, 34725712, 26853435, 34019948, 25367160, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
S1535 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18220336, ...18669648, 19690332
T1539 O-Glycosylation GlyGen 33214551, 28510447, 35138101, ...35254053, 30379171, 32574038, 34725712, 26853435, 34019948, 25367160, 30059200, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
T1539 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 18220336
S1641 Phosphorylation PhosphoSitePlus
S1666 Phosphorylation PhosphoSitePlus
K1676 Acetylation PhosphoSitePlus   UniProt 19608861
K1676 Ubiquitination PhosphoSitePlus
T1697 Phosphorylation PhosphoSitePlus   UniProt 19690332
S1701 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231, ...18220336
S1703 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231
T1718 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18220336, 18669648, ...19690332, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation HPRD 19413330, 20068231
S12 Phosphorylation HPRD 19413330, 20068231
S73 Phosphorylation HPRD 20166139, 18669648, 17081983, ...20068231, 18452278
S75 Phosphorylation HPRD 20166139, 18669648, 17081983, ...20068231, 18452278
S78 Phosphorylation HPRD 20166139, 18669648, 17081983, ...20068231, 18452278
T90 Phosphorylation HPRD 18669648, 20068231
S91 Phosphorylation HPRD 18669648
S125 Phosphorylation HPRD 17287340, 17081983, 19691289, ...19651622, 20166139, 20068231
S179 Phosphorylation HPRD 18669648
S267 Phosphorylation HPRD 18669648, 20068231
T619 Phosphorylation HPRD 20068231
T1062 Phosphorylation HPRD 18452278
Y1063 Phosphorylation HPRD 18452278
Y1076 Phosphorylation HPRD 18452278
S1079 Phosphorylation HPRD 18452278
T1523 Phosphorylation HPRD 18669648, 20068231
S1525 Phosphorylation HPRD 18669648
S1526 Phosphorylation HPRD 18669648, 20068231
T1530 Phosphorylation HPRD 18669648, 17081983, 20068231
T1532 Phosphorylation HPRD 18669648, 17081983, 20068231
S1535 Phosphorylation HPRD 18669648, 17081983, 20068231
T1539 Phosphorylation HPRD 18669648
T1697 Phosphorylation HPRD 19413330, 20068231
S1701 Phosphorylation HPRD 18669648, 20068231
S1703 Phosphorylation HPRD 18669648, 20068231
T1709 Phosphorylation HPRD 17081983
T1718 Phosphorylation HPRD 19413330, 18669648, 17081983, ...20068231
Site PTM Type PTM Enzyme Score Source PMID
T21 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K29 N29 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S75 Y75 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S78 L78 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T90 I90 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S91 C91 Biomuta DOID:1324 / lung cancer [ cosmic ]
S267 N267 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T292 A292 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K358 T358 Biomuta DOID:363 / uterine cancer [ icgc ]
K358 N358 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K452 E452 Biomuta DOID:1612 / breast cancer [ cosmic ]
R511 S511 Biomuta DOID:1324 / lung cancer [ cosmic ]
K816 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S1079 L1079 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y1378 C1378 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1528 R1528 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1701 F1701 Biomuta DOID:4159 / skin cancer [ cosmic ]