iPTMnet Report for Q76N89 (HECW1)
Protein Information
UniProt AC / UniProt ID | Q76N89 / HECW1_HUMAN |
Protein Name | E3 ubiquitin-protein ligase HECW1 |
Gene Name | Name: HECW1 Synonyms:KIAA0322,NEDL1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q76N89 |
PRO Name | E3 ubiquitin-protein ligase HECW1 (human) |
Definition | An E3 ubiquitin-protein ligase HECW1 that is encoded in the genome of human. |
Short Label | hHECW1 |
Category | organism-gene |
Q76N89 (HECW1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K9 | Ubiquitination | score1 | PhosphoSitePlus | |||
S24 | Phosphorylation | score1 | PhosphoSitePlus | |||
S26 | Phosphorylation | score1 | PhosphoSitePlus | |||
S68 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y150 | Phosphorylation | score1 | PhosphoSitePlus | |||
K188 | Ubiquitination | score1 | PhosphoSitePlus | |||
S206 | Phosphorylation | score1 | PhosphoSitePlus | |||
S208 | Phosphorylation | score1 | PhosphoSitePlus | |||
S210 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y228 | Phosphorylation | score1 | PhosphoSitePlus | |||
T493 | O-Glycosylation | score1 | GlyGen | 29351928 | ||
K504 | Ubiquitination | score1 | PhosphoSitePlus | |||
S527 | Phosphorylation | score1 | PhosphoSitePlus | |||
K592 | Ubiquitination | score1 | PhosphoSitePlus | |||
S721 | Phosphorylation | score1 | PhosphoSitePlus | |||
T854 | Phosphorylation | score1 | PhosphoSitePlus | |||
S872 | Phosphorylation | score1 | PhosphoSitePlus | |||
S919 | Phosphorylation | score1 | PhosphoSitePlus | |||
S921 | Phosphorylation | score1 | PhosphoSitePlus | |||
S937 | Phosphorylation | score1 | PhosphoSitePlus | |||
S939 | Phosphorylation | score1 | PhosphoSitePlus | |||
S943 | Phosphorylation | score1 | PhosphoSitePlus | |||
T959 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1075 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1089 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1473 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S24 | T24 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S68 | C68 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S68 | T68 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S527 | T527 | Biomuta | DOID:3571 / liver cancer [ cosmic, icgc ] | |
S527 | W527 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S721 | Y721 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S721 | F721 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S872 | L872 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S939 | F939 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] | |
S939 | Y939 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
S943 | L943 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S1089 | F1089 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |