iPTMnet Report for Q75N03 (CBLL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q75N03 / HAKAI_HUMAN
Protein Name E3 ubiquitin-protein ligase Hakai
Gene Name Name: CBLL1
Synonyms:HAKAI;
Organism Homo sapiens (Human)

PRO ID PR:Q75N03
DAG View
PRO Name E3 ubiquitin-protein ligase Hakai (human)
Definition An E3 ubiquitin-protein ligase Hakai that is encoded in the genome of human.
Short Label hCBLL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q75N03 (CBLL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K29 Acetylation PhosphoSitePlus
K29 Methylation PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
T44 Phosphorylation PhosphoSitePlus
C73 Methylation IEDB 31844290
K74 Ubiquitination PhosphoSitePlus
Y119 Phosphorylation PhosphoSitePlus
Y176 Phosphorylation PhosphoSitePlus
R192 Methylation PhosphoSitePlus
T198 Phosphorylation PhosphoSitePlus
S201 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17287340
R219 Methylation PhosphoSitePlus
S276 O-Glycosylation GlyGen 34846842, 33214551, 32574038, ...30059200, 35254053, 34019948, 31492838, 29351928, 35289036, 30620550, 28657654, 29237092
S278 O-Glycosylation GlyGen 33214551, 32574038, 30059200, ...30620550, 34019948, 31492838, 29351928, 35289036, 35254053, 28657654, 29237092
S278 Phosphorylation PhosphoSitePlus
T281 Phosphorylation PhosphoSitePlus
R283 Methylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus   UniProt 23186163
S290 Phosphorylation PhosphoSitePlus   UniProt 19690332
R458 Methylation PhosphoSitePlus
R465 Methylation PhosphoSitePlus
R485 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S201 Phosphorylation HPRD 18669648, 17287340, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y119 S119 Biomuta DOID:4159 / skin cancer [ cosmic ]
R219 C219 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4362 / cervical cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S276 L276 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
R283 C283 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S290 C290 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R465 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]