iPTMnet Report for Q70Z35 (PREX2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q70Z35 / PREX2_HUMAN
Protein Name Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
Gene Name Name: PREX2
Synonyms:DEPDC2;
Organism Homo sapiens (Human)

PRO ID PR:Q70Z35
DAG View
PRO Name phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (human)
Definition A phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein that is encoded in the genome of human.
Short Label hPREX2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q70Z35 (PREX2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N64 N-Glycosylation GlyGen 26791533
K138 Ubiquitination PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
Y386 Phosphorylation PhosphoSitePlus
S480 Phosphorylation PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
K597 Ubiquitination PhosphoSitePlus
S623 Phosphorylation PhosphoSitePlus
K673 Ubiquitination PhosphoSitePlus
K679 Ubiquitination PhosphoSitePlus
T952 Phosphorylation PhosphoSitePlus
S953 Phosphorylation PhosphoSitePlus
S964 Phosphorylation PhosphoSitePlus
Y1013 Phosphorylation PhosphoSitePlus
T1022 Phosphorylation PhosphoSitePlus
Y1026 Phosphorylation PhosphoSitePlus
K1063 Acetylation PhosphoSitePlus
S1107 Phosphorylation Q13153 (PAK1) , Q13177 (PAK2) PhosphoSitePlus 26438819
S1514 Phosphorylation PhosphoSitePlus
S1551 O-Glycosylation GlyGen 31492838
Y1558 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N64 N-Glycosylation PRO 26791533


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K138 Q138 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K215 M215 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K349 T349 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K349 M349 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S480 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K673 N673 Biomuta DOID:1540 / parathyroid carcinoma [ cosmic ]
T952 N952 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S953 Y953 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S953 T953 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1514 F1514 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]