Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6ZV89 / SH2D5_HUMAN
Protein Name SH2 domain-containing protein 5
Gene Name Name: SH2D5
Organism Homo sapiens (Human)

PRO ID PR:Q6ZV89
DAG View
PRO Name SH2 domain-containing protein 5 (human)
Definition An SH2 domain-containing protein 5 that is encoded in the genome of human.
Short Label hSH2D5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6ZV89 (SH2D5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus
T164 Phosphorylation PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
Y229 Phosphorylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
T233 Phosphorylation PhosphoSitePlus
Y255 Phosphorylation PhosphoSitePlus
T406 Phosphorylation PhosphoSitePlus
S411 Phosphorylation PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T164 R164 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S197 F197 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S231 L231 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
T233 M233 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
S415 F415 Biomuta DOID:4159 / skin cancer [ cosmic ]