iPTMnet Report for Q6ZUT9 (DENND5B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6ZUT9 / DEN5B_HUMAN
Protein Name DENN domain-containing protein 5B
Gene Name Name: DENND5B
Organism Homo sapiens (Human)

PRO ID PR:Q6ZUT9
DAG View
PRO Name DENN domain-containing protein 5B (human)
Definition A DENN domain-containing protein 5B that is encoded in the genome of human.
Short Label hDENND5B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6ZUT9 (DENND5B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22814378
Y176 Phosphorylation PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
T354 Phosphorylation PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
Y445 Phosphorylation PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
K470 Ubiquitination PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
Y496 Phosphorylation PhosphoSitePlus
K543 Ubiquitination PhosphoSitePlus
K613 Ubiquitination PhosphoSitePlus
S691 Phosphorylation PhosphoSitePlus
S724 Phosphorylation PhosphoSitePlus
K815 Ubiquitination PhosphoSitePlus
S822 Phosphorylation PhosphoSitePlus   UniProt 23186163
S833 Phosphorylation PhosphoSitePlus
S835 Phosphorylation PhosphoSitePlus
S873 Phosphorylation IEDB 35494241
K877 Ubiquitination PhosphoSitePlus
K894 Ubiquitination PhosphoSitePlus
T1062 Phosphorylation PhosphoSitePlus
S1068 Phosphorylation PhosphoSitePlus
S1076 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...24275569
T1081 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y496 Phosphorylation HPRD 20068231
S833 Phosphorylation HPRD 18669648
S835 Phosphorylation HPRD 18669648
S1076 Phosphorylation HPRD 18669648, 20068231, 18707149
Site PTM Type PTM Enzyme Score Source PMID
S69 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y176 N176 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S178 C178 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S178 F178 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K421 N421 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S476 Y476 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S833 F833 Biomuta DOID:4159 / skin cancer [ icgc ]
K894 E894 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]