iPTMnet Report for Q6PCD5 (RFWD3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6PCD5 / RFWD3_HUMAN
Protein Name E3 ubiquitin-protein ligase RFWD3
Gene Name Name: RFWD3
Synonyms:RNF201;
Organism Homo sapiens (Human)

PRO ID PR:Q6PCD5
DAG View
PRO Name E3 ubiquitin-protein ligase RFWD3 (human)
Definition An E3 ubiquitin-protein ligase RFWD3 that is encoded in the genome of human.
Short Label hRFWD3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6PCD5 (RFWD3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S46 Phosphorylation Q13315 (ATM) PhosphoSitePlus   RLIMS-P   UniProt 28575658, 28575657, 20173098, ...17478428, 31900333
S63 Phosphorylation Q13315 (ATM) PhosphoSitePlus   RLIMS-P   UniProt 28575658, 28575657, 20173098, ...17478428, 31900333
Y181 Phosphorylation PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
K364 Acetylation PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
K370 Acetylation PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
C379 Methylation IEDB 31844290
K389 Ubiquitination PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
S425 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18077418, 18669648
S427 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332, 18669648
S428 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332, 18077418
K433 Ubiquitination PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
K488 Methylation PhosphoSitePlus
K488 Sumoylation PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K498 Ubiquitination PhosphoSitePlus
K583 Ubiquitination PhosphoSitePlus
K658 Ubiquitination PhosphoSitePlus
T661 Phosphorylation HPRD 17081983
K697 Ubiquitination PhosphoSitePlus
C750 Methylation IEDB 31844290
K766 Ubiquitination PhosphoSitePlus
K772 Sumoylation PhosphoSitePlus
K772 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S266 F266 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S427 F427 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K433 E433 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]