iPTMnet Report for Q6IBS0 (TWF2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6IBS0 / TWF2_HUMAN
Protein Name Twinfilin-2
Gene Name Name: TWF2
Synonyms:PTK9L;ORFNames:MSTP011;
Organism Homo sapiens (Human)

PRO ID PR:Q6IBS0
DAG View
PRO Name twinfilin-2 (human)
Definition A twinfilin-2 that is encoded in the genome of human.
Short Label hTWF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6IBS0 (TWF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
K14 Acetylation PhosphoSitePlus   UniProt 19608861
K19 Acetylation PhosphoSitePlus
C67 Methylation IEDB 31844290
K109 Acetylation PhosphoSitePlus
K110 Acetylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
S139 O-Glycosylation GlyGen 34019948, 34725712, 35132862, ...29351928
C141 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
T148 Phosphorylation PhosphoSitePlus
S149 O-Glycosylation GlyGen 34019948, 34725712, 35132862, ...29351928
K163 Sumoylation PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
Y309 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15592455, 19690332
K315 Ubiquitination PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
R340 Methylation PhosphoSitePlus
S349 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 20166139, 21406692, 18669648, ...19690332


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S149 L149 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R340 H340 Biomuta DOID:9256 / colorectal cancer [ cosmic ]