iPTMnet Report for Q5VY43 (PEAR1)
Protein Information
UniProt AC / UniProt ID | Q5VY43 / PEAR1_HUMAN |
Protein Name | Platelet endothelial aggregation receptor 1 precursor |
Gene Name | Name: PEAR1 Synonyms:MEGF12; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q5VY43 |
PRO Name | platelet endothelial aggregation receptor 1 (human) |
Definition | A platelet endothelial aggregation receptor 1 that is encoded in the genome of human. |
Short Label | hPEAR1 |
Category | organism-gene |
Q5VY43 (PEAR1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T64 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
K81 | Acetylation | score1 | PhosphoSitePlus | |||
S795 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y890 | Phosphorylation | score1 | PhosphoSitePlus | |||
S891 | Phosphorylation | score1 | PhosphoSitePlus | |||
S893 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y925 | Phosphorylation | score3 | HPRD PhosphoSitePlus RLIMS-P UniProt | 15851471 | ||
S953 | Phosphorylation | score3 | HPRD PhosphoSitePlus RLIMS-P UniProt | 15851471 | ||
S964 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y1019 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1029 | Phosphorylation | score3 | HPRD PhosphoSitePlus RLIMS-P UniProt | 15851471 |
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000025639 (hPEAR1/iso:1/Phos:1) | pY925,pS953,pS1029 | PRO | 15851471 |
Proteoform PPIs
Protein 1 | Relation | Protein 2 | Source | PMID | |
---|---|---|---|---|---|
PR:000025639 (hPEAR1/iso:1/Phos:1) | Interaction | PR:P29353 (hSHC1) | PRO | 15851471 | |
PR:000025639 (hPEAR1/iso:1/Phos:1) | Interaction | PR:P98077 (hSHC2) | PRO | 15851471 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S795 | N795 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S891 | N891 | Biomuta | DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] | |
S893 | R893 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
Y1019 | N1019 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] |