iPTMnet Report for Q5SRE5 (NUP188)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5SRE5 / NU188_HUMAN
Protein Name Nucleoporin NUP188
Gene Name Name: NUP188
Synonyms:KIAA0169;
Organism Homo sapiens (Human)

PRO ID PR:Q5SRE5
DAG View
PRO Name nucleoporin NUP188 (human)
Definition A nucleoporin NUP188 that is encoded in the genome of human.
Short Label hNUP188
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5SRE5 (NUP188) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
S13 Phosphorylation PhosphoSitePlus
T18 Phosphorylation PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
K38 Acetylation PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
S69 Phosphorylation IEDB   PhosphoSitePlus 35494241
K72 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
C135 Methylation IEDB 31844290
K164 Ubiquitination PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
Y181 Phosphorylation PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
R251 Methylation PhosphoSitePlus
R264 Methylation PhosphoSitePlus
S269 O-Glycosylation GlyGen 33214551, 34019948, 35083852, ...36240223, 28510447, 22121020
K344 Ubiquitination PhosphoSitePlus
C408 Methylation IEDB 31844290
S456 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K463 Ubiquitination PhosphoSitePlus
K470 Ubiquitination PhosphoSitePlus
K481 Ubiquitination PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
R526 Methylation PhosphoSitePlus
K566 Ubiquitination PhosphoSitePlus
K628 Ubiquitination PhosphoSitePlus
S697 Phosphorylation PhosphoSitePlus
Y718 Phosphorylation PhosphoSitePlus
K720 Ubiquitination PhosphoSitePlus
S798 Phosphorylation PhosphoSitePlus
K812 Ubiquitination PhosphoSitePlus
K862 Ubiquitination PhosphoSitePlus
K876 Ubiquitination PhosphoSitePlus
T903 Phosphorylation PhosphoSitePlus
S907 Phosphorylation PhosphoSitePlus
K908 Ubiquitination PhosphoSitePlus
C976 Methylation IEDB 31844290
K1060 Ubiquitination PhosphoSitePlus
K1065 Acetylation PhosphoSitePlus
K1070 Acetylation PhosphoSitePlus
S1257 Phosphorylation PhosphoSitePlus
K1262 Ubiquitination PhosphoSitePlus
T1267 Phosphorylation PhosphoSitePlus
S1271 Phosphorylation PhosphoSitePlus
K1291 Ubiquitination PhosphoSitePlus
K1386 Ubiquitination PhosphoSitePlus
S1387 Phosphorylation PhosphoSitePlus
K1409 Acetylation PhosphoSitePlus
K1409 Ubiquitination PhosphoSitePlus
K1496 Ubiquitination PhosphoSitePlus
K1505 Ubiquitination PhosphoSitePlus
S1523 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K1533 Ubiquitination PhosphoSitePlus
Y1660 Phosphorylation PhosphoSitePlus
K1684 Ubiquitination PhosphoSitePlus
S1708 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1709 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 15302935, ...16565220
T1712 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1717 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...16964243, 16565220, 18669648, 19690332, 20068231, 17081983
K1721 Ubiquitination PhosphoSitePlus
K1727 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S798 Phosphorylation HPRD 20068231
S1257 Phosphorylation HPRD 19651622
S1696 Phosphorylation HPRD 20068231
S1697 Phosphorylation HPRD 20068231
S1708 Phosphorylation HPRD 18691976, 19664995, 19691289, ...19651622, 18669648, 20068231
S1709 Phosphorylation HPRD 19413330, 18691976, 16964243, ...20058876, 19664995, 16565220, 19651622, 18669648, 19415658, 20068231, 19691289
T1712 Phosphorylation HPRD 19664995, 19691289
S1717 Phosphorylation HPRD 19413330, 18691976, 16964243, ...19664995, 16565220, 19651622, 18669648, 19415658, 20068231, 19691289


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S30 C30 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K65 E65 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K164 I164 Biomuta DOID:4159 / skin cancer [ cosmic ]
R264 Q264 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R526 M526 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R526 K526 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K908 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K1070 N1070 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K1262 M1262 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
T1267 I1267 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1523 F1523 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1684 R1684 Biomuta DOID:363 / uterine cancer [ icgc ]
S1697 G1697 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1709 P1709 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1721 E1721 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1721 N1721 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]