iPTMnet Report for Q5S007 (LRRK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5S007 / LRRK2_HUMAN
Protein Name Leucine-rich repeat serine/threonine-protein kinase 2
Gene Name Name: LRRK2
Synonyms:PARK8;
Organism Homo sapiens (Human)

PRO ID PR:Q5S007
DAG View
PRO Name leucine-rich repeat serine/threonine-protein kinase 2 (human)
Definition A leucine-rich repeat serine/threonine-protein kinase 2 that is encoded in the genome of human.
Short Label hLRRK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5S007 (LRRK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus   RLIMS-P 20108944, 25830304
S5 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 20108944
T358 Phosphorylation PhosphoSitePlus
T424 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 20108944
T489 Phosphorylation PhosphoSitePlus
T496 Phosphorylation PhosphoSitePlus
T524 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 20108944
S633 Phosphorylation PhosphoSitePlus
S634 Phosphorylation PhosphoSitePlus
Y636 Phosphorylation PhosphoSitePlus
Y707 Phosphorylation PhosphoSitePlus
T776 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 20108944
S784 Phosphorylation PhosphoSitePlus
S788 Phosphorylation PhosphoSitePlus
T826 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 20108944
T833 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 20108944
S837 Phosphorylation PhosphoSitePlus
T838 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 20108944
S850 Phosphorylation PhosphoSitePlus
S858 Phosphorylation PhosphoSitePlus
S860 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P 22004453, 20642453
S865 Phosphorylation PhosphoSitePlus
S895 Phosphorylation PhosphoSitePlus
S898 Phosphorylation PhosphoSitePlus
S908 Phosphorylation HPRD   PhosphoSitePlus 20058876
S910 Phosphorylation O14920 (IKBKB) , Q9UHD2 (TBK1) , O15111 (CHUK) , Q14164 (IKBKE) , P17612 (PRKACA) HPRD   neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 22952710, 22723946, 23938344, ...27911006, 24917786, 20642453, 24836358, 22988882, 29513666, 28720718, 24351927, 20058876, 28353283, 17200152, 28202711, 20659021, 24942733, 29212815, 28860483, 25009464, 28353278, 28973420, 22004453
S912 Phosphorylation PhosphoSitePlus
S926 Phosphorylation PhosphoSitePlus
S933 Phosphorylation PhosphoSitePlus
S935 Phosphorylation Q14164 (IKBKE) , O15111 (CHUK) , Q9UHD2 (TBK1) , P17612 (PRKACA) , O14920 (IKBKB) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 22952710, 29311810, 21390248, ...28202711, 31663853, 35950872, 29127256, 27911006, 29127255, 23938344, 31428781, 28453723, 24917786, 20642453, 24836358, 33057100, 22988882, 28353278, 29513666, 28720718, 23916833, 31527116, 30635421, 29743203, 28553204, 35675433, 22723946, 28353283, 32736291, 17200152, 33297425, 20659021, 24942733, 29212815, 29166931, 25118928, 28860483, 25009464, 32499675, 29129681, 29541021, 28973420, 25830304, 22004453, 34125248, 30592011
S954 Phosphorylation PhosphoSitePlus
S955 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 22952710, 29212815, 24917786, ...25009464, 24836358, 33057100, 35950872, 28353283, 26399642, 28353278, 22988882, 17200152, 28202711, 22004453, 29513666, 20642453
S958 Phosphorylation PhosphoSitePlus
S962 Phosphorylation PhosphoSitePlus
S971 Phosphorylation PhosphoSitePlus
S973 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 29212815, 22952710, 20642453, ...24917786, 25009464, 33057100, 35950872, 28353283, 26399642, 28353278, 22988882, 17200152, 28202711, 22004453, 27911006, 29513666
S975 Phosphorylation PhosphoSitePlus
S976 Phosphorylation PhosphoSitePlus
S979 Phosphorylation PhosphoSitePlus
T1024 Phosphorylation PhosphoSitePlus
S1025 Phosphorylation PhosphoSitePlus
S1058 Phosphorylation PhosphoSitePlus
K1118 Ubiquitination PhosphoSitePlus
S1124 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 20108944
K1129 Ubiquitination PhosphoSitePlus
K1138 Acetylation IEDB 34357683
S1157 Phosphorylation PhosphoSitePlus
S1159 Phosphorylation PhosphoSitePlus
T1176 Phosphorylation PhosphoSitePlus
S1219 Phosphorylation PhosphoSitePlus
S1228 Phosphorylation PhosphoSitePlus
S1253 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 21060682
S1283 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 21060682
S1292 Phosphorylation Q5S007 (LRRK2) neXtProt   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 33177079, 33717414, 20108944, ...28453723, 21060682, 31039583, 27832104, 29513666, 30592011, 31527116, 30635421, 29743203, 27297049, 26251043, 26865512, 28353283, 32919031, 29212815, 29166931, 23241745, 29177506, 25009464, 30368241, 29541021, 28973420, 30645642
Y1332 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 21060682
T1343 Phosphorylation Q5S007 (LRRK2) neXtProt   PhosphoSitePlus 20108944, 21806997, 19733152, ...21060682
S1345 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 20108944, 21060682
T1348 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus   RLIMS-P+   RLIMS-P 29212815, 20108944, 23924436
T1349 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus   RLIMS-P+ 23924436
T1357 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus   RLIMS-P+   RLIMS-P 24836358, 21060682, 23924436
T1368 Phosphorylation Q5S007 (LRRK2) neXtProt   PhosphoSitePlus 20108944, 21806997, 21060682
Y1402 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 21060682
S1403 Phosphorylation Q5S007 (LRRK2) neXtProt   PhosphoSitePlus   Signor 21806997, 19824698, 21060682
T1404 Phosphorylation Q5S007 (LRRK2) neXtProt   PhosphoSitePlus   Signor 21806997, 19824698, 21060682
T1410 Phosphorylation Q5S007 (LRRK2) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 20108944, 19824698, 27832104, ...26384650, 21060682, 24942733
S1443 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 21060682
S1444 Phosphorylation Q5S007 (LRRK2) , P17612 (PRKACA) PhosphoSitePlus   RLIMS-P   UniProt 21060682, 24351927, 28202711
S1445 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 21060682
T1452 Phosphorylation Q5S007 (LRRK2) neXtProt   PhosphoSitePlus 20108944, 21060682
S1457 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 21060682
S1467 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 21060682
T1470 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 21060682
Y1485 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 21060682
T1491 Phosphorylation Q5S007 (LRRK2) neXtProt   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor 20108944, 19824698, 25009464, ...24836358, 19733152, 22004453, 21060682
T1503 Phosphorylation Q5S007 (LRRK2) neXtProt   PhosphoSitePlus   RLIMS-P 20108944, 25009464, 24836358, ...21806997, 22004453, 21060682
S1508 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 21060682
S1536 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 21060682
T1612 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 21060682
S1627 Phosphorylation Q00535 (CDK5) PhosphoSitePlus   RLIMS-P+ 26930193
S1647 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 21060682
Y1718 Phosphorylation PhosphoSitePlus
S1721 O-Glycosylation GlyGen 30379171
S1721 Phosphorylation PhosphoSitePlus
K1833 Ubiquitination PhosphoSitePlus
T1849 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 21060682
S1853 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 21060682
T1912 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 21060682
S1913 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 21060682
T1967 Phosphorylation Q5S007 (LRRK2) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 19824698, 21060682
T1969 Phosphorylation Q5S007 (LRRK2) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 19824698, 21060682
Y2018 Phosphorylation PhosphoSitePlus
Y2023 Phosphorylation PhosphoSitePlus
T2031 Phosphorylation Q5S007 (LRRK2) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 20595391, 21060682
S2032 Phosphorylation Q5S007 (LRRK2) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 20595391, 21060682, 18397888
T2035 Phosphorylation Q5S007 (LRRK2) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 20595391, 17260967, 21060682, ...18397888
S2166 Phosphorylation PhosphoSitePlus
T2237 Phosphorylation PhosphoSitePlus
S2257 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 21060682
Y2449 Phosphorylation PhosphoSitePlus
T2460 Phosphorylation PhosphoSitePlus
T2483 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus   RLIMS-P+   RLIMS-P 20108944, 25009464, 29541021
T2524 Phosphorylation Q5S007 (LRRK2) PhosphoSitePlus 21060682


Q5S007 (LRRK2) as PTM Enzyme



Substrate Site Score Source PMID
O15379 (HDAC3) S424 RLIMS-P+ 27798112
O95295 (SNAPIN) T117 neXtProt   PhosphoSitePlus   Signor 23949442
P04637 (TP53) T304 PhosphoSitePlus 26384650
P04637 (TP53) T377 PhosphoSitePlus 26384650
P10636-8 (MAPT) T149 PhosphoSitePlus 24113872
P10636-8 (MAPT) T153 PhosphoSitePlus 24113872
P10636-8 (MAPT) T205 PhosphoSitePlus 24113872
P15311 (EZR) T567 PhosphoSitePlus 17447891
P26038 (MSN) T558 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 19027715, 8537411, 17447891
P30048 (PRDX3) T146 neXtProt   Signor 21850687
P31749 (AKT1) S473 neXtProt   PhosphoSitePlus   Signor 21658387, 24916379
P35241 (RDX) T564 PhosphoSitePlus 17447891
P37840 (SNCA) S129 Signor 19576176
P46459 (NSF) T645 PhosphoSitePlus 26758690
P61020 (RAB5B) T6 PhosphoSitePlus 25605758
P61026 (RAB10) T73 Signor 26824392
P62280 (RPS11) T28 PhosphoSitePlus 24725412
P62280 (RPS11) T46 PhosphoSitePlus 24725412
P62280 (RPS11) T54 PhosphoSitePlus 24725412
P62841 (RPS15) T136 PhosphoSitePlus 24725412
Q13541 (EIF4EBP1) T37 neXtProt 18701920
Q13541 (EIF4EBP1) T46 neXtProt 18701920
Q14155 (ARHGEF7) T127 Signor 21048939
Q14155 (ARHGEF7) T164 Signor 21048939
Q16665 (HIF1A) S797 RLIMS-P+ 26751287
Q5S007 (LRRK2) S3 PhosphoSitePlus 20108944
Q5S007 (LRRK2) S5 PhosphoSitePlus 20108944
Q5S007 (LRRK2) T424 PhosphoSitePlus 20108944
Q5S007 (LRRK2) T524 PhosphoSitePlus 20108944
Q5S007 (LRRK2) T776 PhosphoSitePlus 20108944
Q5S007 (LRRK2) T826 PhosphoSitePlus 20108944
Q5S007 (LRRK2) T833 PhosphoSitePlus 20108944
Q5S007 (LRRK2) T838 PhosphoSitePlus 20108944
Q5S007 (LRRK2) S1124 PhosphoSitePlus 20108944
Q5S007 (LRRK2) S1253 PhosphoSitePlus 21060682
Q5S007 (LRRK2) S1283 PhosphoSitePlus 21060682
Q5S007 (LRRK2) S1292 neXtProt   PhosphoSitePlus   RLIMS-P+ 20108944, 23241745, 25009464, ...27297049, 26251043, 21060682
Q5S007 (LRRK2) Y1332 PhosphoSitePlus 21060682
Q5S007 (LRRK2) T1343 neXtProt   PhosphoSitePlus 20108944, 21806997, 19733152, ...21060682
Q5S007 (LRRK2) S1345 PhosphoSitePlus 20108944, 21060682
Q5S007 (LRRK2) T1348 PhosphoSitePlus   RLIMS-P+ 20108944, 23924436
Q5S007 (LRRK2) T1349 RLIMS-P+ 23924436
Q5S007 (LRRK2) T1357 PhosphoSitePlus   RLIMS-P+ 21060682, 23924436
Q5S007 (LRRK2) T1368 neXtProt   PhosphoSitePlus 20108944, 21806997, 21060682
Q5S007 (LRRK2) Y1402 PhosphoSitePlus 21060682
Q5S007 (LRRK2) S1403 neXtProt   PhosphoSitePlus   Signor 21806997, 19824698, 21060682
Q5S007 (LRRK2) T1404 neXtProt   PhosphoSitePlus   Signor 21806997, 19824698, 21060682
Q5S007 (LRRK2) T1410 neXtProt   PhosphoSitePlus   Signor 20108944, 19824698, 21060682
Q5S007 (LRRK2) S1443 PhosphoSitePlus 21060682
Q5S007 (LRRK2) S1444 PhosphoSitePlus 21060682
Q5S007 (LRRK2) S1445 PhosphoSitePlus 21060682
Q5S007 (LRRK2) T1452 neXtProt   PhosphoSitePlus 20108944, 21060682
Q5S007 (LRRK2) S1457 PhosphoSitePlus 21060682
Q5S007 (LRRK2) S1467 PhosphoSitePlus 21060682
Q5S007 (LRRK2) T1470 PhosphoSitePlus 21060682
Q5S007 (LRRK2) Y1485 PhosphoSitePlus 21060682
Q5S007 (LRRK2) T1491 neXtProt   PhosphoSitePlus   RLIMS-P+   Signor 20108944, 19824698, 25009464, ...19733152, 22004453, 21060682
Q5S007 (LRRK2) T1503 neXtProt   PhosphoSitePlus 20108944, 22004453, 21806997, ...21060682
Q5S007 (LRRK2) S1508 PhosphoSitePlus 21060682
Q5S007 (LRRK2) S1536 PhosphoSitePlus 21060682
Q5S007 (LRRK2) T1612 PhosphoSitePlus 21060682
Q5S007 (LRRK2) S1647 PhosphoSitePlus 21060682
Q5S007 (LRRK2) T1849 PhosphoSitePlus 21060682
Q5S007 (LRRK2) S1853 PhosphoSitePlus 21060682
Q5S007 (LRRK2) T1912 PhosphoSitePlus 21060682
Q5S007 (LRRK2) S1913 PhosphoSitePlus 21060682
Q5S007 (LRRK2) T1967 neXtProt   PhosphoSitePlus   Signor 19824698, 21060682
Q5S007 (LRRK2) T1969 neXtProt   PhosphoSitePlus   Signor 19824698, 21060682
Q5S007 (LRRK2) T2031 neXtProt   PhosphoSitePlus   Signor 20595391, 21060682
Q5S007 (LRRK2) S2032 neXtProt   PhosphoSitePlus   Signor 20595391, 21060682, 18397888
Q5S007 (LRRK2) T2035 neXtProt   PhosphoSitePlus   Signor 20595391, 17260967, 21060682, ...18397888
Q5S007 (LRRK2) S2257 PhosphoSitePlus 21060682
Q5S007 (LRRK2) T2483 PhosphoSitePlus   RLIMS-P+ 20108944, 25009464
Q5S007 (LRRK2) T2524 PhosphoSitePlus 21060682
Q99962 (SH3GL2) S75 Signor 22998870


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q5S007 (LRRK2) S935 P27348 (YWHAQ) inhibited_association eFIP 20642453


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T358 M358 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S633 F633 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y636 H636 Biomuta DOID:1324 / lung cancer [ cosmic ]
T776 M776 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S784 N784 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T833 I833 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S837 Y837 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S858 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S860 T860 Biomuta DOID:1324 / lung cancer [ cosmic ]
S908 P908 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S910 * Biomuta DOID:1319 / brain cancer [ cosmic ]
S910 P910 Biomuta DOID:1319 / brain cancer [ cosmic ]
S912 N912 Biomuta DOID:363 / uterine cancer [ icgc ]
S958 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S971 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S973 N973 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S976 F976 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S979 F979 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S1025 R1025 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K1118 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1124 F1124 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T1176 K1176 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1283 F1283 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ]
S1283 T1283 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S1403 N1403 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1404 N1404 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T1410 K1410 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S1443 T1443 Biomuta DOID:1319 / brain cancer [ cosmic ]
T1452 I1452 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1457 Y1457 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1467 I1467 Biomuta DOID:363 / uterine cancer [ icgc ]
T1491 I1491 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1536 L1536 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1627 A1627 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1627 L1627 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S1647 T1647 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
Y1718 C1718 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1721 L1721 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T1849 N1849 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1853 F1853 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1853 Y1853 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T1912 S1912 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1913 P1913 Biomuta DOID:363 / uterine cancer [ icgc ]
T1967 S1967 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y2023 C2023 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S2032 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y2449 H2449 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T2483 I2483 Biomuta DOID:4159 / skin cancer [ cosmic ]