iPTMnet Report for Q5JRX3 (PITRM1)
Protein Information
UniProt AC / UniProt ID | Q5JRX3 / PREP_HUMAN |
Protein Name | Presequence protease, mitochondrial precursor |
Gene Name | Name: PITRM1 Synonyms:KIAA1104; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q5JRX3 |
PRO Name | presequence protease, mitochondrial (human) |
Definition | A presequence protease, mitochondrial that is encoded in the genome of human. |
Short Label | hPITRM1 |
Category | organism-gene |
Q5JRX3 (PITRM1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y40 | Phosphorylation | score1 | PhosphoSitePlus | |||
T50 | Phosphorylation | score1 | PhosphoSitePlus | |||
T55 | Phosphorylation | score1 | PhosphoSitePlus | |||
S56 | Phosphorylation | score1 | PhosphoSitePlus | |||
T194 | Phosphorylation | score1 | PhosphoSitePlus | |||
K207 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y258 | Phosphorylation | score1 | PhosphoSitePlus | |||
K287 | Ubiquitination | score1 | PhosphoSitePlus | |||
K290 | Ubiquitination | score1 | PhosphoSitePlus | |||
K305 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y388 | Phosphorylation | score1 | PhosphoSitePlus | |||
R424 | Methylation | score1 | PhosphoSitePlus | |||
K473 | Acetylation | score1 | PhosphoSitePlus | |||
K473 | Ubiquitination | score1 | PhosphoSitePlus | |||
K483 | Ubiquitination | score1 | PhosphoSitePlus | |||
K488 | Ubiquitination | score1 | PhosphoSitePlus | |||
K513 | Ubiquitination | score1 | PhosphoSitePlus | |||
S530 | Phosphorylation | score1 | PhosphoSitePlus | |||
R534 | Methylation | score1 | PhosphoSitePlus | |||
K540 | Ubiquitination | score1 | PhosphoSitePlus | |||
S620 | O-Glycosylation | score1 | GlyGen | 28510447, 33465208, 34229054 | ||
S717 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y721 | Phosphorylation | score1 | PhosphoSitePlus | |||
S723 | Phosphorylation | score1 | PhosphoSitePlus | |||
T731 | Phosphorylation | score1 | PhosphoSitePlus | |||
K750 | Ubiquitination | score1 | PhosphoSitePlus | |||
K759 | Acetylation | score1 | PhosphoSitePlus | |||
K759 | Ubiquitination | score1 | PhosphoSitePlus | |||
K770 | Acetylation | score1 | PhosphoSitePlus | |||
K884 | Acetylation | score1 | PhosphoSitePlus | |||
K884 | Ubiquitination | score1 | PhosphoSitePlus | |||
K946 | Acetylation | score1 | PhosphoSitePlus | |||
K946 | Ubiquitination | score1 | PhosphoSitePlus | |||
K956 | Ubiquitination | score1 | PhosphoSitePlus | |||
R1007 | Methylation | score1 | PhosphoSitePlus | |||
T1011 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
Y40 | C40 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
Y258 | H258 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K287 | R287 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
Y388 | C388 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
R424 | Q424 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic ] | |
R424 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S530 | F530 | Biomuta | [ cosmic ] | |
R534 | T534 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
T731 | M731 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] |