iPTMnet Report for Q5D862 (FLG2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5D862 / FILA2_HUMAN
Protein Name Filaggrin-2
Gene Name Name: FLG2
Synonyms:IFPS;
Organism Homo sapiens (Human)

PRO ID PR:Q5D862
DAG View
PRO Name filaggrin-2 (human)
Definition A filaggrin-2 that is encoded in the genome of human.
Short Label hFLG2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5D862 (FLG2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T122 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
Y129 Phosphorylation PhosphoSitePlus
S177 Phosphorylation HPRD 20068231
S225 Phosphorylation PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
T246 Phosphorylation PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
S265 Phosphorylation HPRD 20068231
Y935 Phosphorylation PhosphoSitePlus
S953 Phosphorylation PhosphoSitePlus
S955 Phosphorylation PhosphoSitePlus
S1250 Phosphorylation PhosphoSitePlus
S1252 Phosphorylation PhosphoSitePlus
S1257 Phosphorylation PhosphoSitePlus
S1262 Phosphorylation PhosphoSitePlus
T1265 Phosphorylation PhosphoSitePlus
S1270 Phosphorylation PhosphoSitePlus
S1271 Phosphorylation PhosphoSitePlus
S1273 Phosphorylation PhosphoSitePlus
S1282 Phosphorylation PhosphoSitePlus
T1619 Phosphorylation PhosphoSitePlus
T1996 Phosphorylation PhosphoSitePlus
T1997 Phosphorylation PhosphoSitePlus
S2108 Phosphorylation PhosphoSitePlus
S2115 Phosphorylation PhosphoSitePlus
S2122 Phosphorylation PhosphoSitePlus
S2165 Phosphorylation PhosphoSitePlus
T2173 Phosphorylation PhosphoSitePlus
S2310 Phosphorylation PhosphoSitePlus
Y2312 Phosphorylation PhosphoSitePlus
S2326 Phosphorylation PhosphoSitePlus
S2340 Phosphorylation PhosphoSitePlus
S2341 Phosphorylation PhosphoSitePlus
Y2356 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S265 Y265 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S953 P953 Biomuta DOID:3565 / meningioma [ cosmic ]
S1250 R1250 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1250 G1250 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1257 T1257 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1262 P1262 Biomuta DOID:363 / uterine cancer [ icgc ]
S1270 F1270 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1270 Y1270 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1273 R1273 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1996 A1996 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S2108 Y2108 Biomuta DOID:3571 / liver cancer [ cosmic ]
S2122 P2122 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y2312 H2312 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2340 L2340 Biomuta DOID:4159 / skin cancer [ cosmic ]