iPTMnet Report for Q53EZ4 (CEP55)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q53EZ4 / CEP55_HUMAN
Protein Name Centrosomal protein of 55 kDa
Gene Name Name: CEP55
Synonyms:C10orf3;
Organism Homo sapiens (Human)

PRO ID PR:Q53EZ4
DAG View
PRO Name centrosomal protein of 55 kDa (human)
Definition A centrosomal protein of 55 kDa that is encoded in the genome of human.
Short Label hCEP55
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q53EZ4 (CEP55) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
K22 Ubiquitination PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
T52 Phosphorylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
S144 Phosphorylation PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
T146 Phosphorylation PhosphoSitePlus
T148 Phosphorylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
T154 Phosphorylation PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
Y228 Phosphorylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
Y284 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
Y336 Phosphorylation PhosphoSitePlus
T337 Phosphorylation PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
T360 Phosphorylation PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
S396 Phosphorylation PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
S425 Phosphorylation P28482 (MAPK1) , P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18691976, 17081983, 18669648, ...16198290, 21079244
K427 Ubiquitination PhosphoSitePlus
S428 Phosphorylation P06493 (CDK1) , P28482 (MAPK1) IEDB   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 17081983, 18669648, ...16198290, 21079244, 32387766
T430 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S436 Phosphorylation P53350 (PLK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 17081983, 29743530, ...18669648, 16198290, 21079244
K442 Ubiquitination PhosphoSitePlus
Y461 Phosphorylation PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S425 Phosphorylation P06493 (CDK1) , P28482 (MAPK1) HPRD 19413330, 18691976, 16964243, ...18669648, 16198290, 19415658, 20068231
S428 Phosphorylation P06493 (CDK1) , P28482 (MAPK1) HPRD 19413330, 18691976, 18767875, ...19664994, 19691289, 18452278, 18669648, 16198290, 19415658, 20068231
T430 Phosphorylation HPRD 19413330, 17081983, 18767875, ...18452278, 18669648, 20068231
S436 Phosphorylation P53350 (PLK1) HPRD 19413330, 16964243, 19664994, ...19691289, 18669648, 16198290, 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q53EZ4 (CEP55) S436 P53350 (PLK1) unknown eFIP 16198290


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S21 F21 Biomuta DOID:4159 / skin cancer [ cosmic ]
S23 F23 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ] DOID:1324 / lung cancer [ cosmic, icgc ]
K29 Q29 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K196 E196 Biomuta DOID:1324 / lung cancer [ cosmic ]
K201 N201 Biomuta DOID:363 / uterine cancer [ icgc ]
K222 N222 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K274 E274 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K306 Q306 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y336 H336 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K367 E367 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S428 I428 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S436 I436 Biomuta DOID:3571 / liver cancer [ cosmic ]