iPTMnet Report for Q53EL6 (PDCD4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q53EL6 / PDCD4_HUMAN
Protein Name Programmed cell death protein 4
Gene Name Name: PDCD4
Synonyms:H731;
Organism Homo sapiens (Human)

PRO ID PR:Q53EL6
DAG View
PRO Name programmed cell death protein 4 (human)
Definition A programmed cell death protein 4 that is encoded in the genome of human.
Short Label hPDCD4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q53EL6 (PDCD4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 20068231
S20 Phosphorylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
S25 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
S67 Phosphorylation P31749 (AKT1) , P23443 (RPS6KB1) , Q9UBS0 (RPS6KB2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18296647, 16357133, 31952347, ...24334270, 22431522, 32804243, 30760284, 24275569, 17053147, 22586265, 27028868, 25882842
S68 Phosphorylation PhosphoSitePlus   UniProt 24275569
S71 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 31952347, 24334270, ...24275569, 25882842
R73 Methylation PhosphoSitePlus
S76 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 17081983, 31952347, ...24334270, 25002506, 18669648, 24275569, 27028868, 20068231, 25882842
S78 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...24275569
S80 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S82 Phosphorylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
T90 Phosphorylation PhosphoSitePlus
T93 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus 18669648, 16964243, 27869121
S94 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 33936100, 18669648, ...30784271, 20068231
K96 Ubiquitination PhosphoSitePlus
R110 Methylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
T126 Phosphorylation PhosphoSitePlus
Y131 Phosphorylation PhosphoSitePlus
Y143 Phosphorylation PhosphoSitePlus
Y152 Phosphorylation PhosphoSitePlus   UniProt 15592455
K166 Ubiquitination PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
C227 Methylation IEDB 31844290
K238 Ubiquitination PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
T254 Phosphorylation PhosphoSitePlus
R267 Methylation PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
C288 Methylation IEDB 31844290
K297 Ubiquitination PhosphoSitePlus
T299 Phosphorylation PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S317 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S323 Phosphorylation PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
Y405 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
C433 Methylation IEDB 31844290
S440 Phosphorylation PhosphoSitePlus
S457 Phosphorylation P31749 (AKT1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 21406692, 23186163, 17081983, ...16357133, 18669648, 15144186, 25002506, 17287340, 20661426, 27028868, 20068231, 16964243
K465 Sumoylation PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S49 Phosphorylation HPRD 20068231
S71 Phosphorylation HPRD 18767875, 17081983
S76 Phosphorylation HPRD 17081983, 18767875, 19007248, ...19651622, 18669648, 20166139, 19415658, 20068231, 18212344
S78 Phosphorylation HPRD 19413330, 17081983, 18767875, ...18669648, 20166139, 20068231
S80 Phosphorylation HPRD 18669648, 17081983
T93 Phosphorylation HPRD 16964243, 18767875, 20058876, ...19664995, 19651622, 18669648, 19415658, 20068231, 17081983
S94 Phosphorylation HPRD 19413330, 17081983, 18767875, ...19664994, 19664995, 19651622, 18669648, 20068231
Y152 Phosphorylation HPRD 15592455
S313 Phosphorylation HPRD 20166139
S317 Phosphorylation HPRD 19651622, 20068231
T397 Phosphorylation HPRD 20068231
S457 Phosphorylation HPRD 17287340, 18212344, 18767875, ...15144186, 19651622, 18669648, 20166139, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S38 Phosphorylation HPRD 20068231
S60 Phosphorylation HPRD 18767875, 17081983
S65 Phosphorylation HPRD 17081983, 18767875, 19007248, ...19651622, 18669648, 20166139, 19415658, 20068231, 18212344
S67 Phosphorylation HPRD 19413330, 17081983, 18767875, ...18669648, 20166139, 20068231
S69 Phosphorylation HPRD 18669648, 17081983
T82 Phosphorylation HPRD 16964243, 18767875, 20058876, ...19664995, 19651622, 18669648, 19415658, 20068231, 17081983
S83 Phosphorylation HPRD 19413330, 17081983, 18767875, ...19664994, 19664995, 19651622, 18669648, 20068231
Y141 Phosphorylation HPRD 15592455
S302 Phosphorylation HPRD 20166139
S306 Phosphorylation HPRD 19651622, 20068231
T386 Phosphorylation HPRD 20068231
S446 Phosphorylation HPRD 17287340, 18212344, 18767875, ...15144186, 19651622, 18669648, 20166139, 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q53EL6 (PDCD4) S67 Q13309 (SKP2) unknown eFIP 30760284
Phosphorylation Q53EL6 (PDCD4) S67 P31749 (AKT1) unknown eFIP 30250581