iPTMnet Report for Q4VCS5 (AMOT)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q4VCS5 / AMOT_HUMAN
Protein Name Angiomotin
Gene Name Name: AMOT
Synonyms:KIAA1071;
Organism Homo sapiens (Human)

PRO ID PR:Q4VCS5
DAG View
PRO Name angiomotin (human)
Definition An angiomotin that is encoded in the genome of human.
Short Label hAMOT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q4VCS5 (AMOT) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R24 Methylation PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
Y109 Phosphorylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
S175 Phosphorylation Q9NRM7 (LATS2) PhosphoSitePlus   RLIMS-P 24106267, 24225952, 24101513
S182 O-Glycosylation GlyGen 29249144, 35138101, 30620550, ...34019948, 32870666, 29217192, 29485866, 32119511, 35254053, 28657654
T195 O-Glycosylation GlyGen 29249144, 35138101, 30620550, ...34019948, 32870666, 29217192, 29485866, 32119511, 35254053, 28657654
S196 O-Glycosylation GlyGen 30620550
S200 O-Glycosylation GlyGen 29249144
S213 O-Glycosylation GlyGen 29249144, 35138101, 30620550, ...34019948, 32870666, 29217192, 29485866, 32119511, 35254053, 28657654
K219 Ubiquitination PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
R236 Methylation PhosphoSitePlus
R280 Methylation PhosphoSitePlus
R291 Methylation PhosphoSitePlus
S305 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S309 Phosphorylation IEDB   PhosphoSitePlus 27869121
S312 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
R335 Methylation PhosphoSitePlus
R412 Methylation PhosphoSitePlus
S416 O-Glycosylation GlyGen 30620550
Y420 Phosphorylation PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
K481 Ubiquitination PhosphoSitePlus
K496 Ubiquitination PhosphoSitePlus
Y527 Phosphorylation PhosphoSitePlus
T536 Phosphorylation PhosphoSitePlus   RLIMS-P 27321186
S538 Phosphorylation PhosphoSitePlus   RLIMS-P 27321186
K545 Acetylation PhosphoSitePlus
K553 Ubiquitination PhosphoSitePlus
R575 Methylation PhosphoSitePlus
K585 Ubiquitination PhosphoSitePlus
K594 Sumoylation PhosphoSitePlus
K595 Sumoylation PhosphoSitePlus
Y599 Phosphorylation PhosphoSitePlus
K680 Ubiquitination PhosphoSitePlus
S712 Phosphorylation PhosphoSitePlus
S714 Phosphorylation PhosphoSitePlus
T717 Phosphorylation PhosphoSitePlus
S718 Phosphorylation PhosphoSitePlus
Y719 Phosphorylation PhosphoSitePlus
K739 Ubiquitination PhosphoSitePlus
T750 Phosphorylation PhosphoSitePlus   RLIMS-P 27321186
K758 Ubiquitination PhosphoSitePlus
T776 O-Glycosylation GlyGen 29249144, 35138101, 30620550, ...34019948, 32870666, 29217192, 29485866, 32119511, 35254053, 28657654
S780 O-Glycosylation GlyGen 29249144
S787 Phosphorylation PhosphoSitePlus
S823 Phosphorylation PhosphoSitePlus
Y836 Phosphorylation PhosphoSitePlus
S842 Phosphorylation PhosphoSitePlus
S847 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T848 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
S852 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
S855 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
S1059 Phosphorylation PhosphoSitePlus
T1061 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
Site PTM Type PTM Enzyme Score Source PMID
S305 Phosphorylation HPRD 19413330, 18452278
T308 Phosphorylation HPRD 19413330
Y310 Phosphorylation HPRD 19413330
T652 Phosphorylation HPRD 17287340


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q4VCS5 (AMOT) T750 P46937 (YAP1) inhibited_association eFIP 27321186


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R24 H24 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S175 G175 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S182 L182 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S213 C213 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S213 I213 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R236 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S305 L305 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S305 F305 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S305 P305 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S309 I309 Biomuta DOID:363 / uterine cancer [ icgc ]
R335 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y420 F420 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T536 N536 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S538 L538 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
R575 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
K585 N585 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic ]
K595 N595 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y599 S599 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S714 F714 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S780 L780 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S823 C823 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S823 I823 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S842 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S842 L842 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S855 P855 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]