iPTMnet Report for Q38SD2 (LRRK1)
Protein Information
| UniProt AC / UniProt ID | Q38SD2 / LRRK1_HUMAN |
| Protein Name | Leucine-rich repeat serine/threonine-protein kinase 1 |
| Gene Name | Name: LRRK1 Synonyms:KIAA1790; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q38SD2 |
| PRO Name | leucine-rich repeat serine/threonine-protein kinase 1 (human) |
| Definition | A leucine-rich repeat serine/threonine-protein kinase 1 that is encoded in the genome of human. |
| Short Label | hLRRK1 |
| Category | organism-gene |
DAG ViewQ38SD2 (LRRK1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T30 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T175 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S182 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y183 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S249 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S337 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T358 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S360 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K381 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S405 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K453 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y971 | Phosphorylation | P00533 (EGFR) | score3 | neXtProt PhosphoSitePlus | 22337768 | |
| K1054 | Methylation | score1 | PhosphoSitePlus | |||
| Y1063 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1064 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 36040231 | ||
| S1074 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 36040231 | ||
| T1075 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 36040231 | ||
| Y1098 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1100 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1103 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1104 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1241 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1246 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K1276 | Acetylation | score1 | PhosphoSitePlus | |||
| K1278 | Acetylation | score1 | PhosphoSitePlus | |||
| T1295 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1302 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T1427 | Phosphorylation | P06493 (CDK1) | score2 | PhosphoSitePlus | 26192437 | |
| Y1430 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T1628 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K1678 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S1817 | Phosphorylation | P53350 (PLK1) | score2 | PhosphoSitePlus | 26192437 | |
| S1855 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1858 | Phosphorylation | score1 | PhosphoSitePlus |
Q38SD2 (LRRK1) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| Q96SN8 (CDK5RAP2) | T102 | score2 | PhosphoSitePlus | 26192437 | |
| Q96SN8 (CDK5RAP2) | S140 | score2 | PhosphoSitePlus | 26192437 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T30 | M30 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| T175 | M175 | Biomuta | DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ] | |
| S360 | L360 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| S405 | Y405 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| K453 | N453 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| S1104 | F1104 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S1241 | I1241 | Biomuta | DOID:1319 / brain cancer [ cosmic, icgc ] | |
| K1278 | R1278 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| S1302 | F1302 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| T1427 | S1427 | Biomuta | DOID:1319 / brain cancer [ cosmic, icgc ] | |
| S1858 | N1858 | Biomuta | DOID:1324 / lung cancer [ icgc ] DOID:2531 / hematologic cancer [ cosmic ] |
 |