iPTMnet Report for Q32P28 (P3H1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q32P28 / P3H1_HUMAN
Protein Name Prolyl 3-hydroxylase 1 precursor
Gene Name Name: P3H1
Synonyms:GROS1;ORFNames:PSEC0109;
Organism Homo sapiens (Human)

PRO ID PR:Q32P28
DAG View
PRO Name prolyl 3-hydroxylase 1 (human)
Definition A prolyl 3-hydroxylase 1 that is encoded in the genome of human.
Short Label hP3H1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q32P28 (P3H1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation IEDB   PhosphoSitePlus 27869121
S92 O-Glycosylation GlyGen 30459171
S108 Phosphorylation PhosphoSitePlus
N281 N-Glycosylation GlyGen 24190977
S418 Phosphorylation PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
N467 N-Glycosylation GlyGen 29741879, 24190977
C483 Methylation IEDB 31844290
S505 Phosphorylation PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
K523 Ubiquitination PhosphoSitePlus
N540 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19159218, ...24190977
K662 Ubiquitination PhosphoSitePlus
S706 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y153 Phosphorylation HPRD 20068231
T495 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N281 K281 Biomuta DOID:1319 / brain cancer [ icgc ]
K426 R426 Biomuta DOID:1319 / brain cancer [ icgc ]
K426 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K435 N435 Biomuta DOID:3571 / liver cancer [ cosmic ]
N467 S467 Biomuta DOID:1324 / lung cancer [ cosmic ]
K523 M523 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K662 N662 Biomuta DOID:1793 / pancreatic cancer [ icgc ]