iPTMnet Report for Q29RF7 (PDS5A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q29RF7 / PDS5A_HUMAN
Protein Name Sister chromatid cohesion protein PDS5 homolog A
Gene Name Name: PDS5A
Synonyms:KIAA0648;ORFNames:PIG54;
Organism Homo sapiens (Human)

PRO ID PR:Q29RF7
DAG View
PRO Name sister chromatid cohesion protein PDS5 homolog A (human)
Definition A sister chromatid cohesion protein PDS5 homolog A that is encoded in the genome of human.
Short Label hPDS5A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q29RF7 (PDS5A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
K30 Ubiquitination PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
T38 Phosphorylation PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
T51 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S59 Phosphorylation PhosphoSitePlus
C93 Methylation IEDB 31844290
Y101 Phosphorylation PhosphoSitePlus
Y107 Phosphorylation PhosphoSitePlus
T108 Phosphorylation PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
C154 Methylation IEDB 31844290
T170 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...30379171, 34725712, 34019948, 35132862, 35083852, 28510447, 33465208
S192 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S193 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
K222 Ubiquitination PhosphoSitePlus
C242 Methylation IEDB 31844290
K292 Ubiquitination PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
Y364 Phosphorylation PhosphoSitePlus
K366 Acetylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
K389 Acetylation PhosphoSitePlus
Y426 Phosphorylation PhosphoSitePlus
K427 Acetylation PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
K544 Ubiquitination PhosphoSitePlus
K557 Acetylation PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
K568 Ubiquitination PhosphoSitePlus
C589 Methylation IEDB 31844290
K601 Ubiquitination PhosphoSitePlus
K633 Ubiquitination PhosphoSitePlus
K637 Ubiquitination PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
K727 Ubiquitination PhosphoSitePlus
S762 Phosphorylation PhosphoSitePlus
S779 Phosphorylation IEDB 32387766
S793 Phosphorylation PhosphoSitePlus
K805 Ubiquitination PhosphoSitePlus
R812 Methylation PhosphoSitePlus
K820 Acetylation PhosphoSitePlus
K820 Ubiquitination PhosphoSitePlus
S823 Phosphorylation PhosphoSitePlus
K835 Ubiquitination PhosphoSitePlus
K855 Ubiquitination PhosphoSitePlus
S865 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...30379171, 34725712, 34019948, 35132862, 35083852, 28510447, 33465208
S865 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S870 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T875 Phosphorylation PhosphoSitePlus
K882 Acetylation PhosphoSitePlus
K882 Ubiquitination PhosphoSitePlus
S883 Phosphorylation PhosphoSitePlus
S894 Phosphorylation PhosphoSitePlus
K938 Ubiquitination PhosphoSitePlus
Y949 Phosphorylation PhosphoSitePlus
K974 Acetylation PhosphoSitePlus
K974 Ubiquitination PhosphoSitePlus
S977 Phosphorylation PhosphoSitePlus
Y982 Phosphorylation PhosphoSitePlus
K984 Ubiquitination PhosphoSitePlus
K1058 Ubiquitination PhosphoSitePlus
S1065 Phosphorylation PhosphoSitePlus
C1079 S-Nitrosylation dbSNO 19483679
C1084 S-Nitrosylation dbSNO 19483679
S1097 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...30379171, 34725712, 34019948, 35132862, 35083852, 28510447, 33465208
S1097 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 23186163
K1106 Ubiquitination PhosphoSitePlus
K1113 Acetylation PhosphoSitePlus
K1113 Ubiquitination PhosphoSitePlus
K1119 Ubiquitination PhosphoSitePlus
K1134 Ubiquitination PhosphoSitePlus
K1136 Ubiquitination PhosphoSitePlus
K1146 Acetylation PhosphoSitePlus   UniProt 19608861
K1146 Ubiquitination PhosphoSitePlus
S1149 Phosphorylation PhosphoSitePlus
T1151 Phosphorylation PhosphoSitePlus
T1162 Phosphorylation PhosphoSitePlus
S1172 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S1177 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T1178 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S1182 Phosphorylation PhosphoSitePlus
S1186 Phosphorylation PhosphoSitePlus
S1187 Phosphorylation PhosphoSitePlus
T1192 Phosphorylation PhosphoSitePlus
S1195 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 22067460, ...18669648, 19690332, 20068231
S1206 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1208 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 15302935, ...22067460, 18669648, 24275569, 20068231
K1211 Acetylation PhosphoSitePlus   UniProt 19608861
K1211 Ubiquitination PhosphoSitePlus
K1219 Acetylation PhosphoSitePlus
K1219 Ubiquitination PhosphoSitePlus
S1223 Phosphorylation PhosphoSitePlus
T1227 Phosphorylation PhosphoSitePlus
S1232 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S1233 Phosphorylation PhosphoSitePlus
R1235 Methylation PhosphoSitePlus
T1240 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
K1267 Acetylation PhosphoSitePlus
S1276 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S1278 Phosphorylation PhosphoSitePlus   RLIMS-P 36469004
K1290 Acetylation PhosphoSitePlus   UniProt 19608861
K1294 Acetylation PhosphoSitePlus
S1305 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...16964243, 15302935, 22067460, 18669648, 17924679, 20068231, 17081983
K1315 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T38 A38 Biomuta DOID:363 / uterine cancer [ icgc ]
S59 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S109 Y109 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S193 Y193 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ icgc ]
K292 R292 Biomuta DOID:363 / uterine cancer [ cosmic ]
K427 T427 Biomuta DOID:3571 / liver cancer [ cosmic ]
S762 G762 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S793 P793 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y949 C949 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1113 N1113 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T1151 M1151 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T1178 A1178 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1206 L1206 Biomuta [ cosmic ] DOID:1612 / breast cancer [ icgc ]
S1232 N1232 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
R1235 L1235 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
K1267 N1267 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K1315 N1315 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]