Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16665 / HIF1A_HUMAN
Protein Name Hypoxia-inducible factor 1-alpha
Gene Name Name: HIF1A
Synonyms:BHLHE78,MOP1;
Organism Homo sapiens (Human)

PRO ID PR:Q16665
DAG View
PRO Name hypoxia-inducible factor 1-alpha (human)
Definition A hypoxia-inducible factor 1-alpha that is encoded in the genome of human.
Short Label hHIF1A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16665 (HIF1A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K10 Acetylation PhosphoSitePlus
K10 Sumoylation PhosphoSitePlus
K11 Acetylation PhosphoSitePlus
K12 Acetylation PhosphoSitePlus
K19 Acetylation PhosphoSitePlus
K21 Acetylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
K32 Methylation PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
T63 Phosphorylation PhosphoSitePlus   RLIMS-P 27245613
Y66 Phosphorylation PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
C173 Methylation IEDB 31844290
K185 Sumoylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
C219 Methylation IEDB 31844290
S247 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor   UniProt 20699359, 36027865
S247 Phosphorylation P48730 (CSNK1D) PhosphoSitePlus   Signor 20699359
K251 Ubiquitination PhosphoSitePlus
C255 Methylation IEDB 31844290
R258 Methylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
K377 Sumoylation PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
K389 Acetylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K391 Methylation PhosphoSitePlus
K391 Sumoylation PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
P402 Dihydroxylation IntAct 17986458
S451 Phosphorylation PhosphoSitePlus   RLIMS-P 33550096
T455 Phosphorylation PhosphoSitePlus
T458 Phosphorylation PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus
K477 Sumoylation PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
C520 S-Nitrosylation dbSNO 22178444, 17434127
K532 Acetylation PhosphoSitePlus   UniProt 24681946
K532 Ubiquitination PhosphoSitePlus   UniProt 16862177
K538 Ubiquitination PhosphoSitePlus   UniProt 16862177
K547 Ubiquitination PhosphoSitePlus   UniProt 16862177
S551 Phosphorylation PhosphoSitePlus   UniProt 20889502
T555 Phosphorylation PhosphoSitePlus   UniProt 20889502
P564 Dihydroxylation IntAct 17986458
Y565 Phosphorylation PRO   PhosphoSitePlus
S576 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 18519666, 20889502
S576 Phosphorylation Q9H4B4 (PLK3) neXtProt   PhosphoSitePlus   Signor 18519666, 20889502
S589 Phosphorylation PhosphoSitePlus   UniProt 20889502
K636 Ubiquitination PhosphoSitePlus
S641 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 18519666, 18687685, 16954218
S641 Phosphorylation P27361 (MAPK3) Signor 18519666
S641 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus   Signor 18519666, 18687685, 16954218
S643 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 18519666, 18687685, 16954218
S643 Phosphorylation P27361 (MAPK3) Signor 18519666
S643 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus   Signor 18519666, 18687685, 16954218
K649 Ubiquitination PhosphoSitePlus
T651 Phosphorylation PhosphoSitePlus
T652 Phosphorylation PhosphoSitePlus
S653 Phosphorylation PhosphoSitePlus
S656 Phosphorylation PhosphoSitePlus
S657 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 18519666, 20889502
S657 Phosphorylation Q9H4B4 (PLK3) neXtProt   PhosphoSitePlus   Signor 18519666, 20889502
S668 Phosphorylation IEDB   PhosphoSitePlus   RLIMS-P 24189531, 27869121
S668 Phosphorylation P06493 (CDK1) PhosphoSitePlus 24189531
K674 Acetylation PhosphoSitePlus
K674 Ubiquitination PhosphoSitePlus
K682 Ubiquitination PhosphoSitePlus
S683 Phosphorylation PhosphoSitePlus
S687 Phosphorylation IEDB   PhosphoSitePlus   RLIMS-P 27027353, 30784271, 33936100, ...27920218
S692 Phosphorylation PhosphoSitePlus   RLIMS-P 27245613
S696 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 21095582
S696 Phosphorylation Q13315 (ATM) neXtProt   PhosphoSitePlus   Signor 21095582
T700 Phosphorylation PhosphoSitePlus
K709 Acetylation PhosphoSitePlus   UniProt 24681946
K709 Ubiquitination PhosphoSitePlus
K721 Ubiquitination PhosphoSitePlus
S727 Phosphorylation PhosphoSitePlus
S760 Phosphorylation PhosphoSitePlus
S761 Phosphorylation PhosphoSitePlus
K769 Ubiquitination PhosphoSitePlus
C780 Methylation IEDB 31844290
T796 Phosphorylation phospho.ELM   PhosphoSitePlus 11983697
S797 Phosphorylation PRO   RLIMS-P+ 26751287
S797 Phosphorylation Q5S007 (LRRK2) RLIMS-P+ 26751287
C800 S-Nitrosylation dbSNO 22178444, 15688001, 15023551
S809 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T796 Phosphorylation HPRD 17382325
T796 Phosphorylation P68400 (CSNK2A1) HPRD 17382325


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047696 (hHIF1A/Phos:2) pY565,pS797 PRO


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q92793-1 (hCREBBP/iso:1) Interaction PR:Q16665 (hHIF1A) PRO 9887100