iPTMnet Report for Q16643 (DBN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16643 / DREB_HUMAN
Protein Name Drebrin
Gene Name Name: DBN1
Synonyms:D0S117E;
Organism Homo sapiens (Human)

PRO ID PR:Q16643
DAG View
PRO Name drebrin (human)
Definition A drebrin that is encoded in the genome of human.
Short Label hDBN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16643 (DBN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 12665801
S5 Phosphorylation PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus
Y32 Phosphorylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
Y65 Phosphorylation PhosphoSitePlus
S69 Phosphorylation PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
C96 S-Nitrosylation dbSNO 2212679, 22126794
S134 Phosphorylation PhosphoSitePlus
S141 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 18088087, 23979715, ...18220336, 15302935, 18669648, 23186163, 20068231
S142 Phosphorylation Q00535 (CDK5) IEDB   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 15659558, 17081983, ...28319065, 23979715, 15302935, 18669648, 27869121, 23186163, 17287340, 30625038, 25945928, 31848261, 20068231
T162 Phosphorylation PhosphoSitePlus
Y163 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
T241 Phosphorylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
K295 Acetylation PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus
T331 O-Glycosylation GlyGen 23301498, 34725712, 26853435, ...35254053
T331 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
T335 O-Glycosylation GlyGen 23301498, 34725712, 26853435, ...35254053
T335 Phosphorylation PhosphoSitePlus   UniProt 18669648
S337 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 23186163, ...17081983
S339 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 21406692, 23186163, ...17081983
S341 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 16094384
S342 Phosphorylation PhosphoSitePlus
T343 Phosphorylation PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
T346 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 18669648, 23186163, ...19690332
T377 Phosphorylation PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus   UniProt 24275569
T497 Phosphorylation PhosphoSitePlus   UniProt 24275569
T559 Phosphorylation PhosphoSitePlus
S594 Phosphorylation PhosphoSitePlus
Y597 Phosphorylation PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus
S601 Phosphorylation PhosphoSitePlus
S609 Phosphorylation PhosphoSitePlus
Y622 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
Site PTM Type PTM Enzyme Score Source PMID
S134 Phosphorylation HPRD 20068231
S141 Phosphorylation HPRD 19651622, 15302935, 20068231
S142 Phosphorylation HPRD 17322306, 18578522, 18088087, ...18212344, 18767875, 19664995, 18452278, 19651622, 18669648, 18707149, 20166139, 17287340, 19415658, 20068231
T241 Phosphorylation HPRD 20068231
S312 Phosphorylation HPRD 20068231
T331 Phosphorylation HPRD 18669648
T335 Phosphorylation HPRD 17081983, 19664995, 18452278, ...19651622, 18669648, 18707149, 19415658, 20068231
S337 Phosphorylation HPRD 19413330, 18491316, 19664995, ...19651622, 18669648, 18707149, 19415658, 20068231
S339 Phosphorylation HPRD 19413330, 18088087, 16094384, ...20058876, 19664995, 18452278, 19651622, 18669648, 18707149, 19415658, 20068231
S341 Phosphorylation HPRD 18669648, 19664995, 20068231
S342 Phosphorylation HPRD 18669648, 15345747, 19415658, ...19664995
T343 Phosphorylation HPRD 19413330, 18669648, 20068231
S345 Phosphorylation HPRD 19413330, 18669648, 19664995
T346 Phosphorylation HPRD 19413330, 15345747, 18669648, ...17287340, 19664995
T377 Phosphorylation HPRD 18669648
S381 Phosphorylation HPRD 18669648
S564 Phosphorylation HPRD 17081983
S599 Phosphorylation HPRD 19664995
S601 Phosphorylation HPRD 19413330, 18077418, 18669648, ...19664995
Y622 Phosphorylation HPRD 15592455
Site PTM Type PTM Enzyme Score Source PMID
S136 Phosphorylation HPRD 20068231
S143 Phosphorylation HPRD 19651622, 15302935, 20068231
S144 Phosphorylation HPRD 17322306, 18578522, 18088087, ...18212344, 18767875, 19664995, 18452278, 19651622, 18669648, 18707149, 20166139, 17287340, 19415658, 20068231
T243 Phosphorylation HPRD 20068231
S314 Phosphorylation HPRD 20068231
T333 Phosphorylation HPRD 18669648
T337 Phosphorylation HPRD 17081983, 19664995, 18452278, ...19651622, 18669648, 18707149, 19415658, 20068231
S339 Phosphorylation HPRD 19413330, 18491316, 19664995, ...19651622, 18669648, 18707149, 19415658, 20068231
S341 Phosphorylation HPRD 19413330, 18088087, 16094384, ...20058876, 19664995, 18452278, 19651622, 18669648, 18707149, 19415658, 20068231
S343 Phosphorylation HPRD 18669648, 19664995, 20068231
S344 Phosphorylation HPRD 18669648, 15345747, 19415658, ...19664995
T345 Phosphorylation HPRD 19413330, 18669648, 20068231
S347 Phosphorylation HPRD 19413330, 18669648, 19664995
T348 Phosphorylation HPRD 19413330, 15345747, 18669648, ...17287340, 19664995
T379 Phosphorylation HPRD 18669648
S383 Phosphorylation HPRD 18669648
S566 Phosphorylation HPRD 17081983
S601 Phosphorylation HPRD 19664995
S603 Phosphorylation HPRD 19413330, 18077418, 18669648, ...19664995
Y624 Phosphorylation HPRD 15592455
Site PTM Type PTM Enzyme Score Source PMID
S142 Phosphorylation PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
S647 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P17302 (GJA1) Y247 Q16643 (DBN1) inhibited_association eFIP 30448479


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 T2 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S7 R7 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K79 I79 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T162 N162 Biomuta DOID:263 / kidney cancer [ cosmic ]
S255 F255 Biomuta DOID:4159 / skin cancer [ cosmic ]
S274 L274 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S274 W274 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K295 Q295 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S312 L312 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S314 L314 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S341 F341 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S342 G342 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S343 F343 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S344 G344 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S345 A345 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S347 A347 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S564 L564 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S566 L566 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S594 I594 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S601 L601 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S603 L603 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S609 W609 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S647 L647 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]