iPTMnet Report for Q16625 (OCLN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16625 / OCLN_HUMAN
Protein Name Occludin
Gene Name Name: OCLN
Organism Homo sapiens (Human)

PRO ID PR:Q16625
DAG View
PRO Name occludin (human)
Definition An occludin that is encoded in the genome of human.
Short Label hOCLN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16625 (OCLN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
Y44 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
Y287 Phosphorylation PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus
T305 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S310 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y315 Phosphorylation PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus   UniProt 21406692
Y325 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
Y337 Phosphorylation PhosphoSitePlus
S340 Phosphorylation phospho.ELM   PhosphoSitePlus 11502742
S341 Phosphorylation PhosphoSitePlus
Y342 Phosphorylation PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
S344 Phosphorylation PhosphoSitePlus
T345 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
Y368 Phosphorylation PhosphoSitePlus   UniProt 24275569
S369 Phosphorylation PhosphoSitePlus   UniProt 21406692
S370 Phosphorylation PhosphoSitePlus   UniProt 21406692
T376 Phosphorylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
T393 Phosphorylation PhosphoSitePlus
Y398 Phosphorylation P12931 (SRC) PhosphoSitePlus   RLIMS-P   UniProt 19017651, 22671587
T400 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   RLIMS-P 23758859
Y402 Phosphorylation P12931 (SRC) PhosphoSitePlus   UniProt 19017651
T403 Phosphorylation Q02156 (PRKCE) , P24723 (PRKCH) , Q05513 (PRKCZ) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 21545357, 19114660
T404 Phosphorylation Q02156 (PRKCE) , Q05513 (PRKCZ) , P68400 (CSNK2A1) , P24723 (PRKCH) , P67870 (CSNK2B) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19114660, 21536752, 23758859, ...12804768, 21545357
S408 O-Glycosylation GlyGen 22516225
S408 Phosphorylation P67870 (CSNK2B) , P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22671587, 22516225, 21536752, ...18318008, 12804768, 24275569, 23758859
T424 Phosphorylation Q02156 (PRKCE) , Q05513 (PRKCZ) PhosphoSitePlus   Signor 21545357
T438 Phosphorylation Q02156 (PRKCE) , Q05513 (PRKCZ) PhosphoSitePlus   Signor 21545357
Y443 Phosphorylation PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
Y467 Phosphorylation PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus
Y474 Phosphorylation PhosphoSitePlus
Y481 Phosphorylation PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
S490 O-Glycosylation GlyGen 22516225
S490 Phosphorylation P05771 (PRKCB) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 19125584, 22438576, 19478092, ...27423695, 22516225
Site PTM Type PTM Enzyme Score Source PMID
T305 Phosphorylation HPRD 17525332
S313 Phosphorylation HPRD 20166139
S340 Phosphorylation P17252 (PRKCA) , P05771 (PRKCB) , P05129 (PRKCG) HPRD 11502742
S369 Phosphorylation HPRD 18707149
T376 Phosphorylation HPRD 19664995
T404 Phosphorylation P67870 (CSNK2B) HPRD 12804768
S408 Phosphorylation P67870 (CSNK2B) HPRD 12804768, 20166139
Site PTM Type PTM Enzyme Score Source PMID
Y467 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q16625 (OCLN) S408 P57739 (CLDN2) unknown eFIP 21536752
Phosphorylation Q16625 (OCLN) T404 Q9UDY2 (TJP2) decreased_association eFIP 23758859
Phosphorylation Q16625 (OCLN) S490 Q07157 (TJP1) decreased_association eFIP 19125584


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S40 C40 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S277 P277 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K299 N299 Biomuta DOID:3571 / liver cancer [ cosmic ]
S327 F327 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S341 F341 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ]
S358 L358 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y443 * Biomuta DOID:1324 / lung cancer [ cosmic ]