iPTMnet Report for Q16620 (NTRK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16620 / NTRK2_HUMAN
Protein Name BDNF/NT-3 growth factors receptor precursor
Gene Name Name: NTRK2
Synonyms:TRKB;
Organism Homo sapiens (Human)

PRO ID PR:Q16620
DAG View
PRO Name BDNF/NT-3 growth factors receptor (human)
Definition A BDNF/NT-3 growth factors receptor that is encoded in the genome of human.
Short Label hNTRK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16620 (NTRK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N61 N-Glycosylation GlyGen 29391424
N67 N-Glycosylation GlyGen   UniProt 16335952, 7574684
N95 N-Glycosylation GlyGen   UniProt 23090970, 29391424, 7574684, ...24190977
T97 O-Glycosylation GlyGen 28657654
N121 N-Glycosylation GlyGen   UniProt 16335952, 7574684, 24190977, ...23090970, 29391424, 29741879
S141 Phosphorylation PhosphoSitePlus
T151 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
T161 Phosphorylation PhosphoSitePlus
N178 N-Glycosylation GlyGen   UniProt 29391424, 7574684
N205 N-Glycosylation GlyGen   UniProt 7574684
N241 N-Glycosylation GlyGen   UniProt 23090970, 29671580, 29391424, ...7574684, 24190977
T253 Phosphorylation PhosphoSitePlus
N254 N-Glycosylation GlyGen   UniProt 16335952, 23090970, 29391424, ...7574684, 24190977
S256 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
N280 N-Glycosylation GlyGen   UniProt 7574684
N325 N-Glycosylation GlyGen 29391424
N338 N-Glycosylation GlyGen   UniProt 7574684
N412 N-Glycosylation GlyGen   UniProt 7574684
K461 Acetylation PhosphoSitePlus
S479 Phosphorylation neXtProt 17341134
T506 Phosphorylation PhosphoSitePlus
Y516 Phosphorylation Q16620 (NTRK2) PRO   PhosphoSitePlus 20064930
Y558 Phosphorylation PhosphoSitePlus
T573 Phosphorylation PhosphoSitePlus
S698 Phosphorylation PhosphoSitePlus
Y702 Phosphorylation PRO   PhosphoSitePlus
Y706 Phosphorylation PRO   PhosphoSitePlus   RLIMS-P 24116072
Y707 Phosphorylation PRO   PhosphoSitePlus
Y817 Phosphorylation PRO   PhosphoSitePlus   RLIMS-P 26284337, 28012455
Site PTM Type PTM Enzyme Score Source PMID
N241 N-Glycosylation PRO 29671580
Y516 Phosphorylation Q16620 (NTRK2) HPRD 10533983
Y702 Phosphorylation Q16620 (NTRK2) HPRD 10533983
Y706 Phosphorylation Q16620 (NTRK2) HPRD 10533983
Y707 Phosphorylation Q16620 (NTRK2) HPRD 10533983
Y817 Phosphorylation Q16620 (NTRK2) HPRD 10533983
Site PTM Type PTM Enzyme Score Source PMID
Y516 Phosphorylation Q16620 (NTRK2) HPRD 10533983
Site PTM Type PTM Enzyme Score Source PMID
Y532 Phosphorylation Q16620 (NTRK2) HPRD 10533983
Y718 Phosphorylation Q16620 (NTRK2) HPRD 10533983
Y722 Phosphorylation Q16620 (NTRK2) HPRD 10533983
Y723 Phosphorylation Q16620 (NTRK2) HPRD 10533983
Y833 Phosphorylation Q16620 (NTRK2) HPRD 10533983
Site PTM Type PTM Enzyme Score Source PMID
Y532 Phosphorylation Q16620 (NTRK2) HPRD 10533983


Q16620 (NTRK2) as PTM Enzyme



Substrate Site Score Source PMID
O43559 (FRS3) Y417 HPRD   Signor 11432792
O43559 (FRS3) Y455 HPRD   Signor 11432792
P22001 (KCNA3) Y161 PhosphoSitePlus   Signor 19166614
P22001 (KCNA3) Y162 PhosphoSitePlus   Signor 19166614
P22001 (KCNA3) Y163 PhosphoSitePlus   Signor 19166614
P22001 (KCNA3) Y499 PhosphoSitePlus 19166614
Q00535 (CDK5) Y15 neXtProt 17341134
Q13009 (TIAM1) Y829 neXtProt 16801538
Q16620 (NTRK2) Y516 HPRD   PhosphoSitePlus 10533983, 20064930
Q16620-5 (NTRK2) Y532 HPRD 10533983
Q16620-1 (NTRK2) Y702 HPRD 10533983
Q16620-1 (NTRK2) Y706 HPRD 10533983
Q16620-1 (NTRK2) Y707 HPRD 10533983
Q16620-4 (NTRK2) Y718 HPRD 10533983
Q16620-4 (NTRK2) Y722 HPRD 10533983
Q16620-4 (NTRK2) Y723 HPRD 10533983
Q16620-1 (NTRK2) Y817 HPRD 10533983
Q16620-4 (NTRK2) Y833 HPRD 10533983
Q92529-2 (SHC3) Y218 PhosphoSitePlus 11791173
Q92529-2 (SHC3) Y219 PhosphoSitePlus 11791173
Q92529-2 (SHC3) Y256 PhosphoSitePlus 11791173
Q92529-2 (SHC3) Y257 PhosphoSitePlus 11791173
Q92529-2 (SHC3) Y283 PhosphoSitePlus 11791173
Q92529-2 (SHC3) Y301 PhosphoSitePlus 11791173


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048646 (hNTRK2/SigPep-/Phos:1) pY516,pY702,pY706,pY707,pY817 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T151 I151 Biomuta DOID:1612 / breast cancer [ cosmic ]
N205 H205 Biomuta DOID:1612 / breast cancer [ cosmic ]
N205 K205 Biomuta DOID:1324 / lung cancer [ cosmic ]
T253 I253 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
N254 S254 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S257 F257 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S479 C479 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y516 * Biomuta DOID:363 / uterine cancer [ cosmic ]
Y532 * Biomuta DOID:363 / uterine cancer [ cosmic, cosmic ]
Y558 S558 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic ]