iPTMnet Report for Q16595 (FXN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16595 / FRDA_HUMAN
Protein Name Frataxin, mitochondrial precursor
Gene Name Name: FXN
Synonyms:FRDA,X25;
Organism Homo sapiens (Human)

PRO ID PR:Q16595
DAG View
PRO Name frataxin, mitochondrial (human)
Definition A frataxin, mitochondrial that is encoded in the genome of human.
Short Label hFXN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16595 (FXN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S81 Phosphorylation PhosphoSitePlus
T94 Phosphorylation PhosphoSitePlus
Y118 Phosphorylation P12931 (SRC) PhosphoSitePlus   RLIMS-P 25948553
Y143 Phosphorylation PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
K197 Acetylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
Y205 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T175 Phosphorylation PhosphoSitePlus
T178 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S161 I161 Biomuta DOID:363 / uterine cancer [ cosmic ]
T178 P178 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S187 R187 Biomuta DOID:4159 / skin cancer [ cosmic ]