Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15796 / SMAD2_HUMAN
Protein Name Mothers against decapentaplegic homolog 2
Gene Name Name: SMAD2
Synonyms:MADH2,MADR2;
Organism Homo sapiens (Human)

PRO ID PR:Q15796
DAG View
PRO Name mothers against decapentaplegic homolog 2 (human)
Definition A smad2 that is encoded in the genome of human.
Short Label hSMAD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15796 (SMAD2) as Substrate



Site PTM Type PTM Enzyme Source PMID
T8 Phosphorylation pelm   rlimsp 12193595, 17081983, 11027280
T8 Phosphorylation P24941 (CDK2) rlimsp 19201832
T8 Phosphorylation P27361 (MAPK3) hprd   pelm   psp   uniprot 19413330, 12193595, 18491316, ...18691976, 19651622, 20068231, 11027280
K13 Ubiquitination psp
K20 Acetylation psp
S21 Phosphorylation psp
K39 Acetylation psp
S47 Phosphorylation psp
Y102 Phosphorylation psp
S118 Phosphorylation psp
K121 Ubiquitination psp
Y128 Phosphorylation psp
K157 Ubiquitination psp
Y165 Phosphorylation psp
T172 Phosphorylation psp
T197 Phosphorylation P25098 (ADRBK1) psp 16121194
T220 Phosphorylation P27361 (MAPK3) pelm   psp 12193595
T220 Phosphorylation pelm   rlimsp   uniprot 23546880, 12193595, 11027280
S240 Phosphorylation rlimsp   uniprot 11879191
S245 Phosphorylation pelm   rlimsp   uniprot 18032924, 23831640, 12193595, ...11027280
S245 Phosphorylation P27361 (MAPK3) pelm   psp 12193595
S250 Phosphorylation P27361 (MAPK3) pelm   psp 12193595
S250 Phosphorylation P28482 (MAPK1) hprd   psp 10197981
S250 Phosphorylation pelm   rlimsp   uniprot 18032924, 23831640, 12193595, ...11027280
S255 Phosphorylation pelm   rlimsp   uniprot 12193595, 23831640, 18032924, ...11027280
S255 Phosphorylation P27361 (MAPK3) pelm   psp 12193595
S255 Phosphorylation P28482 (MAPK1) psp 10197981
S260 Phosphorylation Q9UQM7 (CAMK2A) hprd   psp 11027280
S317 Phosphorylation psp
T324 Phosphorylation psp
S417 Phosphorylation Q13177 (PAK2) psp 22393057
K420 Acetylation psp
S458 Phosphorylation hprd   pelm   psp   uniprot 18691976, 18669648, 19415658, ...20068231
S460 Phosphorylation hprd   psp   uniprot 20068231
S464 Phosphorylation O00238 (BMPR1B) pelm   psp 9136927
S464 Phosphorylation P36897 (TGFBR1) hprd   pelm   psp 9346908, 9892009, 8980228
S464 Phosphorylation pelm   rlimsp   uniprot 9346908, 9892009, 11043574, ...8980228
S465 Phosphorylation P36897 (TGFBR1) hprd   pelm   psp   rlimsp   uniprot 23478445, 9136927, 8980228, ...9892009, 15134444, 9346908
S465 Phosphorylation O00238 (BMPR1B) pelm   psp 9136927
S465 Phosphorylation O96013 (PAK4) rlimsp 23934187
S465 Phosphorylation pelm   pro   rlimsp 18032924, 17074756, 9346966, ...15134444, 11043574, 12660320, 9892009
S467 Phosphorylation pelm   pro   rlimsp 18032924, 23934187, 17074756, ...9346966, 15134444, 12660320, 9892009
S467 Phosphorylation O00238 (BMPR1B) pelm   psp 9136927
S467 Phosphorylation P36897 (TGFBR1) hprd   pelm   psp   rlimsp   uniprot 23478445, 9136927, 8980228, ...9892009, 15134444, 9346908
Site PTM Type PTM Enzyme Source PMID
S2 Phosphorylation hprd   psp 20068231
T8 Phosphorylation PR:000026189 (hMAPK3/iso:1/Phos:1) pro 12193595
K19 Acetylation pro   psp 17074756
S110 Phosphorylation Q9UQM7 (CAMK2A) hprd   psp 11027280
T220 Phosphorylation P28482 (MAPK1) hprd   psp 10197981
T220 Phosphorylation PR:000026189 (hMAPK3/iso:1/Phos:1) pro 12193595
T220 Phosphorylation PR:000026196 (MAP2K1/iso:1/Phos:1) pro 10197981
S240 Phosphorylation Q9UQM7 (CAMK2A) hprd   psp 11879191, 11027280
S240 Phosphorylation PR:000003197 (calcium/calmodulin-dependent protein kinase type II chain) pro 11027280
S245 Phosphorylation PR:000026196 (MAP2K1/iso:1/Phos:1) pro 10197981
S245 Phosphorylation P28482 (MAPK1) hprd   psp 10197981
S245 Phosphorylation PR:000026189 (hMAPK3/iso:1/Phos:1) pro 12193595
S250 Phosphorylation PR:000026196 (MAP2K1/iso:1/Phos:1) pro 10197981
S250 Phosphorylation PR:000026189 (hMAPK3/iso:1/Phos:1) pro 12193595
S255 Phosphorylation PR:000026189 (hMAPK3/iso:1/Phos:1) pro 12193595
S255 Phosphorylation PR:000026196 (MAP2K1/iso:1/Phos:1) pro 10197981
S464 Phosphorylation P36896 (ACVR1B) hprd 9892009
S465 Phosphorylation P36896 (ACVR1B) hprd 9892009
S465 Phosphorylation PR:000025963 (transforming growth factor beta type II receptor homodimeric complex phosphorylated form (human)) pro 9346966, 12193595, 8980228, ...11027280
S467 Phosphorylation PR:000025963 (transforming growth factor beta type II receptor homodimeric complex phosphorylated form (human)) pro 9346966, 12193595, 8980228, ...11027280
S467 Phosphorylation P36896 (ACVR1B) hprd 9892009
Site PTM Type PTM Enzyme Source PMID
S435 Phosphorylation pro 17074756
S435 Phosphorylation PR:000025963 (transforming growth factor beta type II receptor homodimeric complex phosphorylated form (human)) pro
S437 Phosphorylation pro 17074756
S437 Phosphorylation PR:000025963 (transforming growth factor beta type II receptor homodimeric complex phosphorylated form (human)) pro


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000025934 (hSMAD2/iso:1/Phos:1) pS465,pS467 PR:000025963 (transforming growth factor beta type II receptor homodimeric complex phosphorylated form (human)) pro 8980228, 9346966
PR:000025935 (hSMAD2/iso:1/Phos:2) pS465,pS467 PR:000025963 (transforming growth factor beta type II receptor homodimeric complex phosphorylated form (human)) pro 12193595
PR:000025935 (hSMAD2/iso:1/Phos:2) pT8,pT220,pS245,pS250,pS255 PR:000026189 (hMAPK3/iso:1/Phos:1) pro 12193595
PR:000025936 (hSMAD2/iso:1/Phos:3) pS240 PR:000003197 (calcium/calmodulin-dependent protein kinase type II chain) pro 11027280
PR:000025936 (hSMAD2/iso:1/Phos:3) pS465,pS467 PR:000025963 (transforming growth factor beta type II receptor homodimeric complex phosphorylated form (human)) pro 11027280
PR:000025937 (hSMAD2/iso:1/Phos:4) pT220,pS245,pS250,pS255 PR:000026196 (MAP2K1/iso:1/Phos:1) pro 10197981
PR:000036554 (hSMAD2/iso:1/AcPhos:1) acK19 pro 17074756
PR:000036554 (hSMAD2/iso:1/AcPhos:1) pS465,pS467 pro 17074756
PR:000025938 (hSMAD2/iso:2/Phos:1) pS435,pS437 PR:000025963 (transforming growth factor beta type II receptor homodimeric complex phosphorylated form (human)) pro
PR:000036556 (hSMAD2/iso:2/AcPhos:1) acK19 pro 17074756
PR:000036556 (hSMAD2/iso:2/AcPhos:1) pS435,pS437 pro 17074756


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q15796 (SMAD2) S467 Q13485 (SMAD4) unknown association efip 9346908, 9346966
Phosphorylation Q15796 (SMAD2) S465 Q13485 (SMAD4) unknown association efip 9346908, 9346966


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025934 (hSMAD2/iso:1/Phos:1) Interaction PR:Q13485 (hSMAD4) pro 9311995
PR:000025935 (hSMAD2/iso:1/Phos:2) Interaction PR:Q13485 (hSMAD4) pro 12193595
PR:000025936 (hSMAD2/iso:1/Phos:3) Interaction PR:Q13485 (hSMAD4) pro 11027280
PR:000045371 (hSMAD2/iso:1/UnPhos:1) Interaction pro 8980228