Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15796 / SMAD2_HUMAN
Protein Name Mothers against decapentaplegic homolog 2
Gene Name Name: SMAD2
Synonyms:MADH2,MADR2;
Organism Homo sapiens (Human)

PRO ID PR:Q15796
DAG View
PRO Name mothers against decapentaplegic homolog 2 (human)
Definition A smad2 that is encoded in the genome of human.
Short Label hSMAD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15796 (SMAD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
S2 Acetylation UniProt 19413330, 22814378, 22223895, ...20068231
S2 Phosphorylation PhosphoSitePlus
T8 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12193595, 23186163, 17081983, ...18691976, 15241418, 19201832, 19115199, 20068231, 11027280
T8 Phosphorylation P24941 (CDK2) neXtProt 15241418, 19201832
T8 Phosphorylation P27361 (MAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 12193595, 19115199, 18691976
K13 Ubiquitination PhosphoSitePlus
K19 Acetylation PhosphoSitePlus   UniProt 17074756
K20 Acetylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
K39 Acetylation PhosphoSitePlus
K46 Sumoylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
Y102 Phosphorylation PhosphoSitePlus
S110 Phosphorylation neXtProt   PhosphoSitePlus   Signor 17392271, 11027280
S110 Phosphorylation Q9H4A3 (WNK1) neXtProt 17392271
S110 Phosphorylation Q9UQM7 (CAMK2A) PhosphoSitePlus   Signor 11027280
S118 Phosphorylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
Y128 Phosphorylation PhosphoSitePlus
K156 Sumoylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
Y165 Phosphorylation PhosphoSitePlus
T172 Phosphorylation PhosphoSitePlus
T197 Phosphorylation PhosphoSitePlus 16121194
T197 Phosphorylation P25098 (GRK2) PhosphoSitePlus 16121194
T220 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23546880, 12193595, 25316549, ...10197981, 19115199, 11027280
T220 Phosphorylation P27361 (MAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12193595, 19115199
T220 Phosphorylation P28482 (MAPK1) PhosphoSitePlus   Signor 12193595, 10197981
S240 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor   UniProt 11879191, 11027280
S240 Phosphorylation Q9UQM7 (CAMK2A) PhosphoSitePlus   Signor 11879191, 11027280
S245 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12193595, 23437179, 26194464, ...23077590, 25316549, 10197981, 26057631, 22880011, 20659902, 23831640, 18032924, 19115199, 11027280
S245 Phosphorylation P27361 (MAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12193595, 19115199
S245 Phosphorylation P28482 (MAPK1) PhosphoSitePlus   Signor 12193595, 10197981
S245 Phosphorylation Q14680 (MELK) neXtProt 20659902
S250 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18032924, 23437179, 26194464, ...23077590, 25316549, 10197981, 26057631, 22880011, 23831640, 12193595, 19115199, 11027280
S250 Phosphorylation P27361 (MAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12193595, 19115199
S250 Phosphorylation P28482 (MAPK1) PhosphoSitePlus   Signor 12193595, 10197981
S255 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18032924, 23437179, 26194464, ...23077590, 25316549, 10197981, 26057631, 22880011, 23831640, 12193595, 19115199, 11027280
S255 Phosphorylation P27361 (MAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12193595, 19115199
S255 Phosphorylation P28482 (MAPK1) PhosphoSitePlus   Signor 12193595, 10197981
S260 Phosphorylation neXtProt   PhosphoSitePlus   Signor 17392271, 11027280
S260 Phosphorylation Q9H4A3 (WNK1) neXtProt 17392271
S260 Phosphorylation Q9UQM7 (CAMK2A) PhosphoSitePlus   Signor 11027280
S317 Phosphorylation PhosphoSitePlus
T324 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus 22393057
S417 Phosphorylation Q13177 (PAK2) PhosphoSitePlus 22393057
K420 Acetylation PhosphoSitePlus
S458 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S460 Phosphorylation PhosphoSitePlus   UniProt 20068231
S464 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 9136927, 8980228, 9346908, ...11043574, 9892009
S464 Phosphorylation O00238 (BMPR1B) phospho.ELM   PhosphoSitePlus 9136927
S464 Phosphorylation P36897 (TGFBR1) neXtProt   phospho.ELM   PhosphoSitePlus 9346908, 8980228
S465 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18032924, 17099224, 23934187, ...9136927, 16709598, 8980228, 26057631, 22880011, 23478445, 9346966, 9346908, 15134444, 11043574, 12660320, 17392271, 9892009, 23937725
S465 Phosphorylation O00238 (BMPR1B) phospho.ELM   PhosphoSitePlus 9136927
S465 Phosphorylation P36897 (TGFBR1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 9346908, 15134444, 23478445, ...8980228
S465 Phosphorylation Q8NER5 (ACVR1C) neXtProt 16709598
S465 Phosphorylation Q9H4A3 (WNK1) neXtProt 17392271
S467 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18032924, 17099224, 23934187, ...9136927, 16709598, 8980228, 26057631, 22880011, 9346966, 9892009, 15134444, 23478445, 12660320, 9346908, 23937725
S467 Phosphorylation O00238 (BMPR1B) phospho.ELM   PhosphoSitePlus 9136927
S467 Phosphorylation P36897 (TGFBR1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 9346908, 15134444, 23478445, ...8980228
S467 Phosphorylation Q8NER5 (ACVR1C) neXtProt 16709598
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 20068231
T8 Phosphorylation HPRD   PRO 19413330, 12193595, 18491316, ...18691976, 19651622, 20068231, 11027280
T8 Phosphorylation P27361 (MAPK3) HPRD 19413330, 12193595, 18491316, ...18691976, 19651622, 20068231, 11027280
T8 Phosphorylation PR:000026189 (hMAPK3/iso:1/Phos:1) PRO 12193595
K19 Acetylation PRO 17074756
S110 Phosphorylation HPRD 11027280
S110 Phosphorylation Q9UQM7 (CAMK2A) HPRD 11027280
T220 Phosphorylation HPRD   PRO 12193595, 10197981
T220 Phosphorylation P28482 (MAPK1) HPRD 10197981
T220 Phosphorylation PR:000026189 (hMAPK3/iso:1/Phos:1) PRO 12193595
T220 Phosphorylation PR:000026196 (MAP2K1/iso:1/Phos:1) PRO 10197981
S240 Phosphorylation HPRD   PRO 11027280
S240 Phosphorylation PR:000003197 (calcium/calmodulin-dependent protein kinase type II chain) PRO 11027280
S240 Phosphorylation Q9UQM7 (CAMK2A) HPRD 11027280
S245 Phosphorylation HPRD   PRO 12193595, 10197981
S245 Phosphorylation P28482 (MAPK1) HPRD 10197981
S245 Phosphorylation PR:000026189 (hMAPK3/iso:1/Phos:1) PRO 12193595
S245 Phosphorylation PR:000026196 (MAP2K1/iso:1/Phos:1) PRO 10197981
S250 Phosphorylation HPRD   PRO 12193595, 10197981
S250 Phosphorylation P28482 (MAPK1) HPRD 10197981
S250 Phosphorylation PR:000026189 (hMAPK3/iso:1/Phos:1) PRO 12193595
S250 Phosphorylation PR:000026196 (MAP2K1/iso:1/Phos:1) PRO 10197981
S255 Phosphorylation PRO 12193595, 10197981
S255 Phosphorylation PR:000026189 (hMAPK3/iso:1/Phos:1) PRO 12193595
S255 Phosphorylation PR:000026196 (MAP2K1/iso:1/Phos:1) PRO 10197981
S260 Phosphorylation HPRD 11027280
S260 Phosphorylation Q9UQM7 (CAMK2A) HPRD 11027280
S458 Phosphorylation HPRD 18691976, 18669648, 19415658, ...20068231
S460 Phosphorylation HPRD 20068231
S464 Phosphorylation HPRD 9346908, 9892009
S464 Phosphorylation P36896 (ACVR1B) HPRD 9892009
S464 Phosphorylation P36897 (TGFBR1) HPRD 9346908, 9892009
S465 Phosphorylation HPRD   PRO 17074756, 12193595, 8980228, ...9346966, 9346908, 9892009, 11027280
S465 Phosphorylation P36896 (ACVR1B) HPRD 9892009
S465 Phosphorylation P36897 (TGFBR1) HPRD 9346908, 9892009
S465 Phosphorylation PR:000025963 (transforming growth factor beta type II receptor homodimeric complex phosphorylated form (human)) PRO 9346966, 12193595, 8980228, ...11027280
S467 Phosphorylation HPRD   PRO 17074756, 12193595, 8980228, ...9346966, 9346908, 9892009, 11027280
S467 Phosphorylation P36896 (ACVR1B) HPRD 9892009
S467 Phosphorylation P36897 (TGFBR1) HPRD 9346908, 9892009
S467 Phosphorylation PR:000025963 (transforming growth factor beta type II receptor homodimeric complex phosphorylated form (human)) PRO 9346966, 12193595, 8980228, ...11027280
Site PTM Type PTM Enzyme Score Source PMID
K19 Acetylation PRO 17074756
S435 Phosphorylation PRO 17074756
S435 Phosphorylation PR:000025963 (transforming growth factor beta type II receptor homodimeric complex phosphorylated form (human)) PRO
S437 Phosphorylation PRO 17074756
S437 Phosphorylation PR:000025963 (transforming growth factor beta type II receptor homodimeric complex phosphorylated form (human)) PRO


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049282 (hSMAD2/InitMet-/Phos:1) pS465,pS467 PRO
PR:000049283 (hSMAD2/InitMet-/Phos:5) pT220,pS465,pS467 PRO
PR:000049284 (hSMAD2/InitMet-/UbiqLys+) ub PRO
PR:000025934 (hSMAD2/iso:1/Phos:1) pS465,pS467 PR:000025963 (transforming growth factor beta type II receptor homodimeric complex phosphorylated form (human)) PRO 8980228, 9346966
PR:000025935 (hSMAD2/iso:1/Phos:2) pS465,pS467 PR:000025963 (transforming growth factor beta type II receptor homodimeric complex phosphorylated form (human)) PRO 12193595
PR:000025935 (hSMAD2/iso:1/Phos:2) pT8,pT220,pS245,pS250,pS255 PR:000026189 (hMAPK3/iso:1/Phos:1) PRO 12193595
PR:000025936 (hSMAD2/iso:1/Phos:3) pS240 PR:000003197 (calcium/calmodulin-dependent protein kinase type II chain) PRO 11027280
PR:000025936 (hSMAD2/iso:1/Phos:3) pS465,pS467 PR:000025963 (transforming growth factor beta type II receptor homodimeric complex phosphorylated form (human)) PRO 11027280
PR:000025937 (hSMAD2/iso:1/Phos:4) pT220,pS245,pS250,pS255 PR:000026196 (MAP2K1/iso:1/Phos:1) PRO 10197981
PR:000036554 (hSMAD2/iso:1/AcPhos:1) acK19 PRO 17074756
PR:000036554 (hSMAD2/iso:1/AcPhos:1) pS465,pS467 PRO 17074756
PR:000025938 (hSMAD2/iso:2/Phos:1) pS435,pS437 PR:000025963 (transforming growth factor beta type II receptor homodimeric complex phosphorylated form (human)) PRO
PR:000036556 (hSMAD2/iso:2/AcPhos:1) acK19 PRO 17074756
PR:000036556 (hSMAD2/iso:2/AcPhos:1) pS435,pS437 PRO 17074756


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P49841 (GSK3B) S9 Q15796 (SMAD2) increased_association eFIP 21996745
Phosphorylation Q15796 (SMAD2) S465 Q13485 (SMAD4) unknown eFIP 9346908
Phosphorylation Q15796 (SMAD2) S467 Q13485 (SMAD4) unknown eFIP 9346908
Phosphorylation Q15796 (SMAD2) S465 Q13485 (SMAD4) unknown eFIP 9346966
Phosphorylation Q15796 (SMAD2) S467 Q13485 (SMAD4) unknown eFIP 9346966


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025934 (hSMAD2/iso:1/Phos:1) Interaction PR:Q13485 (hSMAD4) PRO 9311995
PR:000025935 (hSMAD2/iso:1/Phos:2) Interaction PR:Q13485 (hSMAD4) PRO 12193595
PR:000025936 (hSMAD2/iso:1/Phos:3) Interaction PR:Q13485 (hSMAD4) PRO 11027280
PR:000045371 (hSMAD2/iso:1/UnPhos:1) Interaction PRO 8980228
PR:O95405-1 (hZFYVE9/iso:1) Interaction PR:000025960 (hSMAD2/iso:[1/2]/Unphos:1) PRO 11877415, 9865696