iPTMnet Report for Q15796 (SMAD2)
Protein Information
| UniProt AC / UniProt ID | Q15796 / SMAD2_HUMAN |
| Protein Name | Mothers against decapentaplegic homolog 2 |
| Gene Name | Name: SMAD2 Synonyms:MADH2,MADR2; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q15796 |
| PRO Name | mothers against decapentaplegic homolog 2 (human) |
| Definition | A smad2 that is encoded in the genome of human. |
| Short Label | hSMAD2 |
| Category | organism-gene |
DAG ViewQ15796 (SMAD2) as Substrate
 | Site | PTM Type | PTM Enzyme |
Score
| Source | PMID |
|---|---|---|---|---|---|---|
| Ubiquitination | score1 | PRO | ||||
| S2 | Acetylation | score1 | UniProt | 19413330, 22814378, 22223895, ... | ||
| S2 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S3 | Phosphorylation | score0 | RLIMS-P | 30356176 | ||
| T8 | Phosphorylation | P27361 (MAPK3) , P24941 (CDK2) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 18691976, 23186163, 17081983, ... | |
| K13 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K19 | Acetylation | score3 | PhosphoSitePlus UniProt | 17074756 | ||
| K20 | Acetylation | score1 | PhosphoSitePlus | |||
| S21 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K39 | Acetylation | score1 | PhosphoSitePlus | |||
| K46 | Sumoylation | score1 | PhosphoSitePlus | |||
| S47 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K54 | Acetylation | score1 | PhosphoSitePlus | |||
| K63 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C81 | Methylation | score1 | IEDB | 31844290 | ||
| T98 | Phosphorylation | score0 | RLIMS-P | 28912531 | ||
| Y102 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S110 | Phosphorylation | Q9UQM7 (CAMK2A) , Q9H4A3 (WNK1) | score4 | neXtProt PhosphoSitePlus Signor | 17392271, 11027280 | |
| S118 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K121 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y128 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K156 | Sumoylation | score1 | PhosphoSitePlus | |||
| K156 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K157 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y165 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T172 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T197 | Phosphorylation | P25098 (GRK2) | score2 | PhosphoSitePlus | 16121194 | |
| T220 | Phosphorylation | P28482 (MAPK1) , P27361 (MAPK3) | score4 | neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt | 12193595, 25316549, 10197981, ... | |
| S240 | Phosphorylation | Q9UQM7 (CAMK2A) | score4 | PhosphoSitePlus RLIMS-P Signor UniProt | 11879191, 11027280 | |
| S245 | Phosphorylation | P27361 (MAPK3) , Q14680 (MELK) , P28482 (MAPK1) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 12193595, 23437179, 26194464, ... | |
| S250 | Phosphorylation | P28482 (MAPK1) , P27361 (MAPK3) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 18032924, 23437179, 26194464, ... | |
| S255 | Phosphorylation | P27361 (MAPK3) , P28482 (MAPK1) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 12193595, 23437179, 26194464, ... | |
| S260 | Phosphorylation | Q9UQM7 (CAMK2A) , Q9H4A3 (WNK1) | score4 | neXtProt PhosphoSitePlus Signor | 17392271, 11027280 | |
| S317 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T324 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 28400474 | ||
| S417 | Phosphorylation | Q13177 (PAK2) | score2 | PhosphoSitePlus | 22393057 | |
| K420 | Acetylation | score1 | PhosphoSitePlus | |||
| S458 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 20068231 | ||
| S460 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 20068231 | ||
| S464 | Phosphorylation | P36897 (TGFBR1) , O00238 (BMPR1B) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 9346908, 9892009, 8980228, ... | |
| S465 | Phosphorylation | Q9H4A3 (WNK1) , P36897 (TGFBR1) , PR:000025963 (h(TGFBR2/iso:1/SigPep-/Phos:1)*2) , O00238 (BMPR1B) , O96013 (PAK4) , Q8NER5 (ACVR1C) | score4 | neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P+ RLIMS-P UniProt | 30135653, 26057631, 22880011, ... | |
| S467 | Phosphorylation | Q8NER5 (ACVR1C) , PR:000025963 (h(TGFBR2/iso:1/SigPep-/Phos:1)*2) , O00238 (BMPR1B) , P36897 (TGFBR1) | score4 | neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P UniProt | 30135653, 26057631, 22880011, ... |
| Site | PTM Type | PTM Enzyme |
Score
| Source | PMID |
|---|---|---|---|---|---|---|
| S2 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T8 | Phosphorylation | P27361 (MAPK3) , PR:000026189 (hMAPK3/iso:1/Phos:1) | score4 | HPRD PRO | 19413330, 12193595, 18491316, ... | |
| K19 | Acetylation | score2 | PRO | 17074756 | ||
| S110 | Phosphorylation | Q9UQM7 (CAMK2A) | score1 | HPRD | 11027280 | |
| T220 | Phosphorylation | PR:000026196 (MAP2K1/iso:1/Phos:1) , P28482 (MAPK1) , PR:000026189 (hMAPK3/iso:1/Phos:1) | score4 | HPRD PRO | 12193595, 10197981 | |
| S240 | Phosphorylation | Q9UQM7 (CAMK2A) , PR:000003197 (calcium/calmodulin-dependent protein kinase type II chain) | score3 | HPRD PRO | 11027280 | |
| S245 | Phosphorylation | PR:000026189 (hMAPK3/iso:1/Phos:1) , P28482 (MAPK1) , PR:000026196 (MAP2K1/iso:1/Phos:1) | score4 | HPRD PRO | 12193595, 10197981 | |
| S250 | Phosphorylation | P28482 (MAPK1) , PR:000026196 (MAP2K1/iso:1/Phos:1) , PR:000026189 (hMAPK3/iso:1/Phos:1) | score4 | HPRD PRO | 12193595, 10197981 | |
| S255 | Phosphorylation | PR:000026189 (hMAPK3/iso:1/Phos:1) , PR:000026196 (MAP2K1/iso:1/Phos:1) | score3 | PRO | 12193595, 10197981 | |
| S260 | Phosphorylation | Q9UQM7 (CAMK2A) | score1 | HPRD | 11027280 | |
| S458 | Phosphorylation | score0 | HPRD | 18691976, 18669648, 19415658, ... | ||
| S460 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S464 | Phosphorylation | P36897 (TGFBR1) , P36896 (ACVR1B) | score2 | HPRD | 9346908, 9892009 | |
| S465 | Phosphorylation | PR:000025963 (h(TGFBR2/iso:1/SigPep-/Phos:1)*2) , P36896 (ACVR1B) , P36897 (TGFBR1) | score4 | HPRD PRO | 17074756, 12193595, 8980228, ... | |
| S467 | Phosphorylation | P36896 (ACVR1B) , PR:000025963 (h(TGFBR2/iso:1/SigPep-/Phos:1)*2) , P36897 (TGFBR1) | score4 | HPRD PRO | 17074756, 12193595, 8980228, ... |
| Site | PTM Type | PTM Enzyme |
Score
| Source | PMID |
|---|---|---|---|---|---|---|
| K19 | Acetylation | score2 | PRO | 17074756 | ||
| S435 | Phosphorylation | PR:000025963 (h(TGFBR2/iso:1/SigPep-/Phos:1)*2) | score2 | PRO | 17074756 | |
| S437 | Phosphorylation | PR:000025963 (h(TGFBR2/iso:1/SigPep-/Phos:1)*2) | score2 | PRO | 17074756 |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000049282 (hSMAD2/InitMet-/Phos:1) | pS465,pS467 | PRO | |||
| PR:000049283 (hSMAD2/InitMet-/Phos:5) | pT220,pS465,pS467 | PRO | |||
| PR:000049284 (hSMAD2/InitMet-/UbiqLys+) | ub | PRO | |||
| PR:000050145 (hSMAD2/Phos:1) | pS465,pS467 | PR:000025963 (h(TGFBR2/iso:1/SigPep-/Phos:1)*2) | PRO | 8980228, 9346966 | |
| PR:000025934 (hSMAD2/iso:Long/Phos:1) | pS465,pS467 | PR:000025963 (h(TGFBR2/iso:1/SigPep-/Phos:1)*2) | PRO | 8980228, 9346966 | |
| PR:000025935 (hSMAD2/iso:Long/Phos:2) | pS465,pS467 | PR:000025963 (h(TGFBR2/iso:1/SigPep-/Phos:1)*2) | PRO | 12193595 | |
| PR:000025935 (hSMAD2/iso:Long/Phos:2) | pT8,pT220,pS245,pS250,pS255 | PR:000026189 (hMAPK3/iso:1/Phos:1) | PRO | 12193595 | |
| PR:000025936 (hSMAD2/iso:Long/Phos:3) | pS240 | PR:000003197 (calcium/calmodulin-dependent protein kinase type II chain) | PRO | 11027280 | |
| PR:000025936 (hSMAD2/iso:Long/Phos:3) | pS465,pS467 | PR:000025963 (h(TGFBR2/iso:1/SigPep-/Phos:1)*2) | PRO | 11027280 | |
| PR:000025937 (hSMAD2/iso:Long/Phos:4) | pT220,pS245,pS250,pS255 | PR:000026196 (MAP2K1/iso:1/Phos:1) | PRO | 10197981 | |
| PR:000036554 (hSMAD2/iso:Long/AcPhos:1) | acK19 | PRO | 17074756 | ||
| PR:000036554 (hSMAD2/iso:Long/AcPhos:1) | pS465,pS467 | PRO | 17074756 | ||
| PR:000025938 (hSMAD2/iso:Short/Phos:1) | pS435,pS437 | PR:000025963 (h(TGFBR2/iso:1/SigPep-/Phos:1)*2) | PRO | ||
| PR:000036556 (hSMAD2/iso:Short/AcPhos:1) | acK19 | PRO | 17074756 | ||
| PR:000036556 (hSMAD2/iso:Short/AcPhos:1) | pS435,pS437 | PRO | 17074756 |
Proteoform PPIs
| Protein 1 | Relation | Protein 2 | Source | PMID |
|---|---|---|---|---|---|
| PR:000025934 (hSMAD2/iso:Long/Phos:1) | Interaction | PR:Q13485 (hSMAD4) | PRO | 9311995 | |
| PR:000025935 (hSMAD2/iso:Long/Phos:2) | Interaction | PR:Q13485 (hSMAD4) | PRO | 12193595 | |
| PR:000025936 (hSMAD2/iso:Long/Phos:3) | Interaction | PR:Q13485 (hSMAD4) | PRO | 11027280 | |
| PR:000045371 (hSMAD2/iso:Long/UnPhos:1) | Interaction | PRO | 8980228 | ||
| PR:O95405-1 (hZFYVE9/iso:1) | Interaction | PR:000025960 (hSMAD2/iso:[Long/Short]/UnPhos:1) | PRO | 11877415, 9865696 |
