iPTMnet Report for Q15768 (EFNB3)
Protein Information
| UniProt AC / UniProt ID | Q15768 / EFNB3_HUMAN |
| Protein Name | Ephrin-B3 precursor |
| Gene Name | Name: EFNB3 Synonyms:EPLG8,LERK8; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q15768 |
| PRO Name | ephrin-B3 (human) |
| Definition | An ephrin-B3 that is encoded in the genome of human. |
| Short Label | hEFNB3 |
| Category | organism-gene |
DAG ViewQ15768 (EFNB3) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S268 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S274 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| Y311 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y318 | Phosphorylation | score2 | PRO PhosphoSitePlus | |||
| Y323 | Phosphorylation | score2 | PRO PhosphoSitePlus | |||
| S332 | Phosphorylation | score0 | RLIMS-P | 26479588 | ||
| Y337 | Phosphorylation | score2 | PRO PhosphoSitePlus | |||
| Y338 | Phosphorylation | score1 | PhosphoSitePlus |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000047259 (hEFNB3/SigPep-/Phos:1) | pY318,pY323,pY337 | PRO |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | Q15768 (EFNB3) | S332 | P78352 (DLG4) | inhibited_association | eFIP | 26479588 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S274 | F274 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| Y323 | C323 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S332 | G332 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S332 | N332 | Biomuta | DOID:1324 / lung cancer [ cosmic ] |
