iPTMnet Report for Q15596 (NCOA2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15596 / NCOA2_HUMAN
Protein Name Nuclear receptor coactivator 2
Gene Name Name: NCOA2
Synonyms:BHLHE75,SRC2,TIF2;
Organism Homo sapiens (Human)

PRO ID PR:Q15596
DAG View
PRO Name nuclear receptor coactivator 2 (human)
Definition A nuclear receptor coactivator 2 that is encoded in the genome of human.
Short Label hNCOA2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15596 (NCOA2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330
S2 O-Glycosylation GlyGen 23301498, 26960196, 33214551, ...35138101, 30379171, 30059200, 34019948, 32119511, 28657654, 29237092
S2 Phosphorylation PhosphoSitePlus
T8 Phosphorylation PhosphoSitePlus
S29 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163
K31 Acetylation PhosphoSitePlus
T76 Phosphorylation PhosphoSitePlus
K78 Acetylation PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
K239 Sumoylation PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
T456 Phosphorylation HPRD 20068231
T457 Phosphorylation PhosphoSitePlus
S469 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   Signor 22158970, 33593309, 29170386, ...20068231
S469 Phosphorylation P50750 (CDK9) PhosphoSitePlus   Signor 22158970, 29170386
S469 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 22158970
S471 Phosphorylation HPRD   PhosphoSitePlus 20068231
S474 Phosphorylation HPRD   PhosphoSitePlus 20068231
S487 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22158970, 33593309, 29170386, ...20068231
S487 Phosphorylation P50750 (CDK9) PhosphoSitePlus   Signor 22158970, 29170386
S487 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 22158970
R489 Methylation PhosphoSitePlus
S493 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22158970, 23186163, 17081983, ...19664994, 29170386, 33593309, 24275569, 20068231
S493 Phosphorylation P50750 (CDK9) PhosphoSitePlus   Signor 22158970, 29170386
S493 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 22158970
S499 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22158970, 33593309, 29170386, ...20068231
S499 Phosphorylation P50750 (CDK9) PhosphoSitePlus   Signor 22158970, 29170386
S499 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 22158970
R501 Methylation PhosphoSitePlus
S554 Phosphorylation PhosphoSitePlus   UniProt 24275569
S565 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 24275569
S579 Phosphorylation PhosphoSitePlus
K636 Acetylation PhosphoSitePlus
K640 Acetylation PhosphoSitePlus   UniProt 19608861
K640 Sumoylation PhosphoSitePlus
K640 Ubiquitination PhosphoSitePlus
S655 Phosphorylation PhosphoSitePlus
S660 Phosphorylation PhosphoSitePlus
S668 Phosphorylation HPRD 20068231
T669 Phosphorylation PhosphoSitePlus
S671 Phosphorylation PhosphoSitePlus
S675 Phosphorylation PhosphoSitePlus
T681 Phosphorylation HPRD 20068231
S682 Phosphorylation PhosphoSitePlus   UniProt 23186163
S697 Phosphorylation PhosphoSitePlus
S698 Phosphorylation HPRD   PhosphoSitePlus 19664995
S699 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 19664994, ...19664995, 17322306, 18669648, 24275569, 20068231
K705 Methylation PhosphoSitePlus
K705 Ubiquitination PhosphoSitePlus
K713 Acetylation PhosphoSitePlus
S716 Phosphorylation HPRD   PhosphoSitePlus 18077418
S719 Phosphorylation PhosphoSitePlus
S721 Phosphorylation HPRD 20068231
T722 Phosphorylation HPRD 20068231
S726 Phosphorylation HPRD   PhosphoSitePlus 20068231
T729 Phosphorylation HPRD   PhosphoSitePlus 20068231
K731 Sumoylation PhosphoSitePlus
S736 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 11301320, 18669648, ...33593309, 16410316, 20068231
S736 Phosphorylation P27361 (MAPK3) PhosphoSitePlus 11301320
S736 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 11301320
S736 Phosphorylation Q16539 (MAPK14) neXtProt 16410316
K738 Acetylation PhosphoSitePlus
K739 Acetylation PhosphoSitePlus
Y747 Phosphorylation PhosphoSitePlus
K765 Sumoylation PhosphoSitePlus
S771 Phosphorylation PhosphoSitePlus   UniProt 23186163
T773 Phosphorylation PhosphoSitePlus
K780 Acetylation PhosphoSitePlus   UniProt 19608861
K785 Acetylation PhosphoSitePlus   UniProt 19608861
K785 Sumoylation PhosphoSitePlus
K785 Ubiquitination PhosphoSitePlus
K788 Sumoylation PhosphoSitePlus
T847 Phosphorylation PhosphoSitePlus
S851 Phosphorylation HPRD   PhosphoSitePlus 20068231
T854 Phosphorylation HPRD   PhosphoSitePlus 20068231
R874 Methylation PhosphoSitePlus
T964 O-Glycosylation GlyGen 23301498, 26960196, 33214551, ...35138101, 30379171, 32938750, 30059200, 34019948, 32119511, 28657654, 29237092
K1129 Sumoylation PhosphoSitePlus
R1162 Methylation PhosphoSitePlus
R1169 Methylation PhosphoSitePlus
R1173 Methylation PhosphoSitePlus   UniProt 24129315
R1177 Methylation PhosphoSitePlus   UniProt 24129315
R1190 Methylation PhosphoSitePlus   UniProt 24129315
R1196 Methylation PhosphoSitePlus   UniProt 24129315
R1203 Methylation PhosphoSitePlus   UniProt 24129315
R1221 Methylation PhosphoSitePlus   UniProt 24129315
R1240 Methylation PhosphoSitePlus
R1248 Methylation PhosphoSitePlus
R1250 Methylation PhosphoSitePlus
R1261 Methylation PhosphoSitePlus   UniProt 24129315
R1266 Methylation PhosphoSitePlus   UniProt 24129315
K1454 Sumoylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S195 R195 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S471 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S487 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
R489 K489 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S499 N499 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
R501 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S565 F565 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S655 L655 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S668 T668 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S682 L682 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S699 F699 Biomuta DOID:363 / uterine cancer [ icgc ]
S716 N716 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T729 A729 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K788 N788 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R874 * Biomuta DOID:1319 / brain cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
R874 Q874 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R1162 Q1162 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R1162 W1162 Biomuta DOID:363 / uterine cancer [ icgc ]
R1169 H1169 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R1169 C1169 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ]
R1196 C1196 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:10534 / stomach cancer [ cosmic ]
R1196 H1196 Biomuta DOID:363 / uterine cancer [ icgc ]
R1203 H1203 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
R1203 C1203 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
R1240 S1240 Biomuta DOID:1324 / lung cancer [ cosmic ]
R1240 M1240 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R1240 G1240 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R1248 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
R1248 Q1248 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R1261 Q1261 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ]