iPTMnet Report for Q15436 (SEC23A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15436 / SC23A_HUMAN
Protein Name Protein transport protein Sec23A
Gene Name Name: SEC23A
Organism Homo sapiens (Human)

PRO ID PR:Q15436
DAG View
PRO Name protein transport protein Sec23A (human)
Definition A protein transport protein Sec23A that is encoded in the genome of human.
Short Label hSEC23A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15436 (SEC23A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Acetylation UniProt 22814378, 22223895
T43 Phosphorylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
C74 Methylation IEDB 31844290
K81 Ubiquitination PhosphoSitePlus
S97 O-Glycosylation GlyGen 29161034
S102 O-Glycosylation GlyGen 29161034
S115 O-Glycosylation GlyGen 29161034
S116 O-Glycosylation GlyGen 29161034
T137 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30397120, 34725712, 21740066, 34019948, 29161034, 20305658
S150 Phosphorylation PhosphoSitePlus
T168 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30397120, 34725712, 21740066, 34019948, 29161034, 20305658
S184 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30397120, 34725712, 21740066, 34019948, 29161034, 20305658
K185 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus   RLIMS-P 28486929
K208 Ubiquitination PhosphoSitePlus
S226 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30397120, 34725712, 21740066, 34019948, 29161034, 20305658
T241 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30397120, 34725712, 21740066, 34019948, 29161034, 20305658
K307 Ubiquitination PhosphoSitePlus
T308 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S312 Phosphorylation RLIMS-P 28486929
K329 Ubiquitination PhosphoSitePlus
T355 O-Glycosylation GlyGen 29161034
T367 O-Glycosylation GlyGen 29161034
S376 O-Glycosylation GlyGen 29161034
T379 O-Glycosylation GlyGen 29161034
S380 O-Glycosylation GlyGen 29161034
K392 Ubiquitination PhosphoSitePlus
T405 Phosphorylation PhosphoSitePlus   RLIMS-P 28486929
C423 Methylation IEDB 31844290
K429 Ubiquitination PhosphoSitePlus
C432 Ubiquitination PhosphoSitePlus
C444 Methylation IEDB 31844290
C449 Ubiquitination PhosphoSitePlus
T508 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30397120, 34725712, 21740066, 34019948, 29161034, 20305658
S516 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30397120, 34725712, 21740066, 34019948, 29161034, 20305658
K562 Ubiquitination PhosphoSitePlus
S571 O-Glycosylation GlyGen 29161034
T573 O-Glycosylation GlyGen 29161034
S575 O-Glycosylation GlyGen 29161034
S587 O-Glycosylation GlyGen 29161034
S588 O-Glycosylation GlyGen 29161034
S588 Phosphorylation PhosphoSitePlus
S596 O-Glycosylation GlyGen 29161034
S600 O-Glycosylation GlyGen 29161034
S601 O-Glycosylation GlyGen 29161034
S627 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30397120, 34725712, 21740066, 34019948, 29161034, 20305658
S629 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30397120, 34725712, 21740066, 34019948, 29161034, 20305658
S639 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30397120, 34725712, 21740066, 34019948, 29161034, 20305658
S640 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30397120, 34725712, 21740066, 34019948, 29161034, 20305658
S641 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30397120, 34725712, 21740066, 34019948, 29161034, 20305658
K669 Ubiquitination PhosphoSitePlus
S670 Phosphorylation PhosphoSitePlus
Y678 Phosphorylation PhosphoSitePlus
S713 Phosphorylation PhosphoSitePlus
S725 O-Glycosylation GlyGen 29161034
T727 O-Glycosylation GlyGen 29161034
S738 O-Glycosylation GlyGen 29161034
S738 Phosphorylation PRO
T744 O-Glycosylation GlyGen 29161034
T744 Phosphorylation PRO
S748 O-Glycosylation GlyGen 29161034
Site PTM Type PTM Enzyme Score Source PMID
T308 Phosphorylation HPRD 18669648


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049183 (hSEC23A/Phos:1) pS738,pT744 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q15436 (SEC23A) S207 O94979 (SEC31A) decreased_association eFIP 28486929


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S115 F115 Biomuta DOID:1612 / breast cancer [ icgc ]
S115 C115 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S150 F150 Biomuta [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T308 K308 Biomuta DOID:1612 / breast cancer [ cosmic ]
T308 A308 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S312 L312 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K329 N329 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T379 A379 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S380 F380 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K392 E392 Biomuta DOID:3571 / liver cancer [ cosmic ]
T405 M405 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C423 F423 Biomuta DOID:1324 / lung cancer [ cosmic ]
C432 Y432 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
C444 S444 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S516 Y516 Biomuta DOID:363 / uterine cancer [ icgc ]
S571 L571 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T573 A573 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S575 F575 Biomuta DOID:4159 / skin cancer [ cosmic ]
S627 F627 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S639 I639 Biomuta DOID:363 / uterine cancer [ icgc ]
S641 C641 Biomuta DOID:3571 / liver cancer [ cosmic ]
S713 N713 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S713 G713 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S738 C738 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T744 I744 Biomuta DOID:4159 / skin cancer [ cosmic ]