iPTMnet Report for Q15427 (SF3B4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15427 / SF3B4_HUMAN
Protein Name Splicing factor 3B subunit 4
Gene Name Name: SF3B4
Synonyms:SAP49;
Organism Homo sapiens (Human)

PRO ID PR:Q15427
DAG View
PRO Name splicing factor 3B subunit 4 (human)
Definition A splicing factor 3B subunit 4 that is encoded in the genome of human.
Short Label hSF3B4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15427 (SF3B4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895
Y16 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
T42 Phosphorylation PhosphoSitePlus
Y56 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15592455
S63 Phosphorylation PhosphoSitePlus
Y69 Phosphorylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
Y117 Phosphorylation HPRD 20068231
T129 Phosphorylation PhosphoSitePlus
S141 Phosphorylation HPRD   PhosphoSitePlus 20068231
R390 Methylation PhosphoSitePlus
R398 Methylation PhosphoSitePlus
R409 Methylation PhosphoSitePlus
R415 Methylation PhosphoSitePlus
R419 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K82 N82 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T129 S129 Biomuta DOID:1324 / lung cancer [ cosmic ]
R390 Q390 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R390 L390 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R415 Q415 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R415 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R419 Q419 Biomuta DOID:4159 / skin cancer [ cosmic ]
R419 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:3277 / thymus cancer [ cosmic ]