iPTMnet Report for Q15418 (RPS6KA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15418 / KS6A1_HUMAN
Protein Name Ribosomal protein S6 kinase alpha-1
Gene Name Name: RPS6KA1
Synonyms:MAPKAPK1A,RSK1;
Organism Homo sapiens (Human)

PRO ID PR:Q15418
DAG View
PRO Name ribosomal protein S6 kinase alpha-1 (human)
Definition A ribosomal protein S6 kinase alpha-1 that is encoded in the genome of human.
Short Label hRPS6KA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15418 (RPS6KA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S45 Phosphorylation IEDB   PhosphoSitePlus 27920218
T47 Phosphorylation RLIMS-P 21273600
K51 Ubiquitination PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus   UniProt 19369195
K56 Ubiquitination PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
K75 Acetylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
Y91 Phosphorylation PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
K110 Sumoylation PhosphoSitePlus
Y138 Phosphorylation PhosphoSitePlus
S154 Phosphorylation RLIMS-P 12618428
K189 Ubiquitination PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
Y220 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S221 Phosphorylation Q15418 (RPS6KA1) , O15530 (PDPK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20957203, 16458888, 22130794, ...17192257, 9430688, 10480933, 20048145, 33260349, 7642538
T225 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17192257
Y228 Phosphorylation PhosphoSitePlus
T272 O-Glycosylation GlyGen 23301498, 30379171, 33214551, ...30059200, 35254053
K278 Ubiquitination PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus   UniProt 19369195
K316 Ubiquitination PhosphoSitePlus
K335 Sumoylation PhosphoSitePlus
T359 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 21406692, 23186163, ...17081983, 19171933, 19369195, 19371592, 17192257, 9430688, 28646679, 24277696, 18669648, 26580203
S363 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 21406692, 23186163, ...17081983, 19171933, 19369195, 19371592, 12618428, 17192257, 9430688, 28646679, 24277696, 18669648, 26580203, 24275569
S369 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18669648, 23186163, ...17192257
S380 Phosphorylation P49137 (MAPKAPK2) , P41279 (MAP3K8) , Q13237 (PRKG2) , Q15418 (RPS6KA1) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 12618428, 17192257, 22216126, ...18691976, 23186163, 29652799, 16458888, 9430688, 29594152, 24275569, 29615689, 26862730, 18551195, 32605013, 26580203, 19804365, 20957203, 19369195, 25513777, 17906627, 18669648, 20068231, 25579842
T384 Phosphorylation PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus
K410 Ubiquitination PhosphoSitePlus
K421 Sumoylation PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
K453 Ubiquitination PhosphoSitePlus
Y466 Phosphorylation PhosphoSitePlus
T474 Phosphorylation PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
Y486 Phosphorylation PhosphoSitePlus
T489 Phosphorylation PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
K505 Ubiquitination PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus
T522 Phosphorylation PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
K562 Ubiquitination PhosphoSitePlus
T573 Phosphorylation P28482 (MAPK1) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 32637030, 25730857, 16458888, ...22130794, 22357623, 9430688, 18669648, 9687510, 7642538
Y576 Phosphorylation PhosphoSitePlus
T577 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K587 Ubiquitination PhosphoSitePlus
K633 Ubiquitination PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus
K649 Ubiquitination PhosphoSitePlus
K654 Ubiquitination PhosphoSitePlus
K667 Ubiquitination PhosphoSitePlus
K678 Ubiquitination PhosphoSitePlus
K680 Ubiquitination PhosphoSitePlus
S684 Phosphorylation PhosphoSitePlus
S687 Phosphorylation PhosphoSitePlus
T701 Phosphorylation PhosphoSitePlus
Y702 Phosphorylation PhosphoSitePlus
S703 Phosphorylation PhosphoSitePlus
K709 Ubiquitination PhosphoSitePlus
S732 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 16083285, 19808666, 22130794, ...9430688, 18669648
T733 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T734 O-Glycosylation GlyGen 23301498, 30379171, 33214551, ...30059200, 35254053
T734 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T25 Phosphorylation HPRD 18691976
S154 Phosphorylation HPRD 12618428
Y220 Phosphorylation HPRD 18691976, 20068231
S221 Phosphorylation O15530 (PDPK1) HPRD 10480933, 18767875, 20058876, ...9430688
T225 Phosphorylation Q15418 (RPS6KA1) HPRD 17192257, 20068231
Y228 Phosphorylation HPRD 20068231
T359 Phosphorylation P28482 (MAPK1) HPRD 18691976, 18212344, 9430688, ...19651622, 18669648, 20068231
S363 Phosphorylation P28482 (MAPK1) HPRD 18691976, 12618428, 9430688, ...19651622, 18669648, 20068231
S369 Phosphorylation HPRD 19651622, 18691976, 18669648, ...18212344, 20068231
S380 Phosphorylation Q15418 (RPS6KA1) HPRD 18691976, 12618428, 9430688, ...19651622, 18669648, 20068231, 10648825
T573 Phosphorylation HPRD 18691976, 18669648, 9430688
Y576 Phosphorylation HPRD 18691976
T577 Phosphorylation Q15418 (RPS6KA1) HPRD 18669648, 17192257
S732 Phosphorylation HPRD 18691976, 18669648, 20068231, ...9430688
T733 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
R21 Methylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
T30 Phosphorylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
S163 Phosphorylation HPRD 12618428
Y229 Phosphorylation HPRD 18691976, 20068231
S230 Phosphorylation O15530 (PDPK1) HPRD 10480933, 18767875, 20058876, ...9430688
T234 Phosphorylation Q15418 (RPS6KA1) HPRD 17192257, 20068231
Y237 Phosphorylation HPRD 20068231
T368 Phosphorylation P28482 (MAPK1) HPRD 18691976, 18212344, 9430688, ...19651622, 18669648, 20068231
S372 Phosphorylation P28482 (MAPK1) HPRD 18691976, 12618428, 9430688, ...19651622, 18669648, 20068231
S378 Phosphorylation HPRD 19651622, 18691976, 18669648, ...18212344, 20068231
S389 Phosphorylation Q15418 (RPS6KA1) HPRD 18691976, 12618428, 9430688, ...19651622, 18669648, 20068231, 10648825
T582 Phosphorylation HPRD 18691976, 18669648, 9430688
Y585 Phosphorylation HPRD 18691976
T586 Phosphorylation Q15418 (RPS6KA1) HPRD 18669648, 17192257
S741 Phosphorylation HPRD 18691976, 18669648, 20068231, ...9430688
T742 Phosphorylation HPRD 18669648, 20068231


Q15418 (RPS6KA1) as PTM Enzyme



Substrate Site Score Source PMID
O00418 (EEF2K) S366 HPRD   neXtProt   PhosphoSitePlus   Signor 11500364, 20837011, 14709557, ...15024086, 11171059
O14727 (APAF1) S268 PhosphoSitePlus 22246185
O14727 (APAF1) S357 PhosphoSitePlus 22246185
O14757 (CHEK1) S280 PhosphoSitePlus 22357623, 23108403
O60343 (TBC1D4) S341 RLIMS-P+ 17617058
O60343 (TBC1D4) S751 RLIMS-P+ 17617058
O75030 (MITF) S409 neXtProt   PhosphoSitePlus   Signor 10673502, 21749389
P01100-1 (FOS) S362 HPRD   PhosphoSitePlus   Signor 1545828, 8248197, 11585927, ...20068231, 18452278
P03372-1 (ESR1) S118 HPRD 12093745, 9528769
P03372 (ESR1) S167 HPRD   neXtProt   PhosphoSitePlus   Signor 7838153, 11432835, 19925796, ...9528769, 11139588, 11507039
P11831 (SRF) S103 HPRD 10318869, 10753652, 8413226
P13796 (LCP1) S5 PhosphoSitePlus 26631483
P16144 (ITGB4) S1364 PhosphoSitePlus 20870721
P16220 (CREB1) S119 Signor 10558990
P16220-1 (CREB1) S133 HPRD 11175347, 9687510, 9829964, ...12235136, 8688081
P17676 (CEBPB) T235 neXtProt 11684016
P17676-1 (CEBPB) T266 HPRD 10635333
P19634 (SLC9A1) S703 PhosphoSitePlus   Signor 10400637
P21333 (FLNA) S2152 PhosphoSitePlus   Signor 15024089
P22736 (NR4A1) S351 HPRD   neXtProt 11274386, 16223362, 18669648
P23588 (EIF4B) S422 neXtProt   PhosphoSitePlus   Signor 16763566, 15071500
P25963 (NFKBIA) S32 HPRD   neXtProt   PhosphoSitePlus 8601309, 9914500, 9214631, ...9261139, 10723127, 16822942, 9721103
P25963 (NFKBIA) S36 neXtProt 9261139, 16822942, 9214631
P29317 (EPHA2) S897 PhosphoSitePlus 26158630
P30304 (CDC25A) S293 PhosphoSitePlus   Signor 23708659
P30304 (CDC25A) S295 PhosphoSitePlus   Signor 23708659
P30305 (CDC25B) S353 PhosphoSitePlus   Signor 23708659
P30305 (CDC25B) T355 PhosphoSitePlus   Signor 23708659
P30307 (CDC25C) S247 PhosphoSitePlus 23708659
P32004-1 (L1CAM) S1152 HPRD 8663493
P42345 (MTOR) T2446 HPRD 15905173
P42345 (MTOR) S2448 HPRD 18691976, 19664994, 10910062
P43354-1 (NR4A2) S347 HPRD 16223362
P46527 (CDKN1B) T198 neXtProt 14504289
P49427 (CDC34) T162 RLIMS-P+ 27786305
P49815 (TSC2) S1798 HPRD   neXtProt   PhosphoSitePlus   Signor 15342917, 20068231
P49841 (GSK3B) S9 neXtProt   PhosphoSitePlus   Signor 16039586, 7980435, 8250835, ...11584304
P50549-1 (ETV1) S191 HPRD   neXtProt   Signor 12569367, 11551945, 12917345, ...12213813
P50549 (ETV1) S216 HPRD   neXtProt   Signor 12569367, 11551945, 12917345, ...12213813
P50549 (ETV1) S334 HPRD   neXtProt 12569367, 12213813
P50552 (VASP) T278 PhosphoSitePlus   Signor 21423205
P53355 (DAPK1) S289 neXtProt   PhosphoSitePlus 16213824
P60983 (GMFB) T27 HPRD   PhosphoSitePlus 9030586
P62753 (RPS6) S235 neXtProt   PhosphoSitePlus   Signor 17360704
P62753 (RPS6) S236 neXtProt   PhosphoSitePlus   Signor 17360704
P62753 (RPS6) S240 Signor 21233202
P62753 (RPS6) S244 Signor 21233202
P67809 (YBX1) S102 neXtProt   PhosphoSitePlus   Signor 19036157
P78371 (CCT2) S260 PhosphoSitePlus   Signor 21440620, 19332537
P84243 (H3-3B) S11 Signor 10464286, 14625384, 15994958
Q04206 (RELA) S536 neXtProt 15802625
Q05195 (MXD1) S145 PhosphoSitePlus   Signor 18451027
Q07889 (SOS1) S1134 PhosphoSitePlus 22827337
Q07889 (SOS1) S1161 PhosphoSitePlus 22827337
Q13164 (MAPK7) S496 PhosphoSitePlus 22267842
Q15418 (RPS6KA1) S221 Signor 20048145
Q15418-1 (RPS6KA1) T225 HPRD 17192257, 20068231
Q15418-2 (RPS6KA1) T234 HPRD 17192257, 20068231
Q15418-1 (RPS6KA1) S380 HPRD   UniProt 18691976, 12618428, 9430688, ...19651622, 18669648, 20068231, 10648825
Q15418-2 (RPS6KA1) S389 HPRD 18691976, 12618428, 9430688, ...19651622, 18669648, 20068231, 10648825
Q15418-1 (RPS6KA1) T577 HPRD 18669648, 17192257
Q15418-2 (RPS6KA1) T586 HPRD 18669648, 17192257
Q15653 (NFKBIB) S19 neXtProt 16822942
Q15653 (NFKBIB) S23 neXtProt 16822942
Q15831 (STK11) S428 neXtProt   Signor 25846811, 11297520
Q16821-1 (PPP1R3A) S46 HPRD 10648825
Q16875 (PFKFB3) S461 RLIMS-P+ 22115192
Q8IX03 (WWC1) T929 PhosphoSitePlus   Signor 24269383
Q8IX03 (WWC1) S947 PhosphoSitePlus   Signor 24269383
Q8N122 (RPTOR) S719 neXtProt   PhosphoSitePlus   Signor 18722121
Q8N122 (RPTOR) S721 neXtProt   PhosphoSitePlus   Signor 18722121
Q8N122 (RPTOR) S722 neXtProt   PhosphoSitePlus   Signor 18722121
Q8TB45 (DEPTOR) S286 PhosphoSitePlus   Signor 22017877, 22017876
Q8TB45 (DEPTOR) S287 PhosphoSitePlus   Signor 22017877, 22017876
Q8TB45 (DEPTOR) S291 PhosphoSitePlus   Signor 22017877, 22017876
Q92570 (NR4A3) S376 HPRD   Signor 16223362
Q92570-3 (NR4A3) S387 HPRD 16223362
Q92882 (OSTF1) S202 PhosphoSitePlus 21501342
Q92934 (BAD) S75 HPRD   neXtProt   PhosphoSitePlus   Signor 16767165, 12897128, 18246127, ...10880354, 10521512, 14678993, 10679322, 10558990, 9381178, 10837486
Q92934 (BAD) S99 neXtProt 10679322
Q92934 (BAD) S118 HPRD   Signor 20166139, 10837486, 18669648, ...10949026, 18707149
Q92934 (BAD) S153 HPRD   Signor 10880354, 10949026, 10837486
Q96RK0 (CIC) S173 PhosphoSitePlus   Signor 21087211
Q9H6Z4 (RANBP3) S126 PhosphoSitePlus   Signor 18280241
Q9HC62 (SENP2) T369 PhosphoSitePlus 25689261
Q9UBP6-1 (METTL1) S27 HPRD   PhosphoSitePlus   Signor 15861136
Q9UN36 (NDRG2) S332 PhosphoSitePlus 15461589
Q9UN36 (NDRG2) S350 PhosphoSitePlus 15461589
Q9Y2V2 (CARHSP1) S52 PhosphoSitePlus   Signor 15910284


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049123 (hRPS6KA1/Phos:1) pS221,pS363,pS380,pT573 PRO
PR:000049124 (hRPS6KA1/Phos:2) pS221,pT359,pS363,pS380,pT573,pS732 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S31 P31 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S45 P45 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S45 F45 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K66 N66 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S72 F72 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S221 A221 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S230 A230 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S307 F307 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
K335 T335 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
S369 N369 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S378 N378 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S380 T380 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S389 T389 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S402 L402 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K453 Q453 Biomuta DOID:3571 / liver cancer [ cosmic ]
T577 A577 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
T586 A586 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S687 C687 Biomuta DOID:4159 / skin cancer [ cosmic ]
S687 F687 Biomuta DOID:1612 / breast cancer [ cosmic ]
T701 M701 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T701 A701 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
T701 P701 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S732 F732 Biomuta DOID:4159 / skin cancer [ cosmic ]
S741 F741 Biomuta DOID:4159 / skin cancer [ cosmic ]