iPTMnet Report for Q15417 (CNN3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15417 / CNN3_HUMAN
Protein Name Calponin-3
Gene Name Name: CNN3
Organism Homo sapiens (Human)

PRO ID PR:Q15417
DAG View
PRO Name calponin-3 (human)
Definition A calponin-3 that is encoded in the genome of human.
Short Label hCNN3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15417 (CNN3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Phosphorylation PhosphoSitePlus
K6 Acetylation PhosphoSitePlus
K6 Ubiquitination PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
Y10 Phosphorylation P12931 (SRC) PhosphoSitePlus 18698806
S13 Phosphorylation PhosphoSitePlus
K23 Acetylation PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
C59 Methylation IEDB 31844290
C59 S-Nitrosylation dbSNO 19483679
K156 Acetylation PhosphoSitePlus
K158 Methylation PhosphoSitePlus   UniProt 24129315
K158 Ubiquitination PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
K172 Methylation PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
C173 Methylation IEDB 31844290
C173 S-Nitrosylation dbSNO 26338901
S175 Phosphorylation PhosphoSitePlus
Y182 Phosphorylation PhosphoSitePlus
T184 Phosphorylation PhosphoSitePlus
R185 Methylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
T224 Phosphorylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
T234 Phosphorylation PhosphoSitePlus
N240 N-Glycosylation GlyGen 29741879, 24190977
T242 Phosphorylation PhosphoSitePlus
S244 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
K251 Ubiquitination PhosphoSitePlus
S254 Phosphorylation PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
S259 Phosphorylation PhosphoSitePlus
Y261 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
C273 Methylation IEDB 31844290
S285 Phosphorylation PhosphoSitePlus
T288 Phosphorylation PhosphoSitePlus
S293 Phosphorylation O75116 (ROCK2) PhosphoSitePlus   RLIMS-P 20861310
S296 Phosphorylation PhosphoSitePlus   RLIMS-P 20861310
Y300 Phosphorylation PhosphoSitePlus
Y308 Phosphorylation PhosphoSitePlus
Y316 Phosphorylation PhosphoSitePlus
Y320 Phosphorylation PhosphoSitePlus
Y322 Phosphorylation PhosphoSitePlus
S323 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983
Site PTM Type PTM Enzyme Score Source PMID
S162 Phosphorylation HPRD 18212344
S244 Phosphorylation HPRD 17287340
Y261 Phosphorylation P06241 (FYN) HPRD 15206927
T290 Phosphorylation HPRD 17081983
S296 Phosphorylation HPRD 17081983
S323 Phosphorylation HPRD 17081983, 19664995


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S43 N43 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
C173 Y173 Biomuta DOID:1319 / brain cancer [ cosmic ]
R185 K185 Biomuta [ cosmic ]
S215 I215 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T224 A224 Biomuta DOID:4159 / skin cancer [ cosmic ]
S244 F244 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T288 K288 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
Y316 H316 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S323 R323 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]